Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48714 |
Resumo: | Socios En Salud Sucursal Peru, Lima, Peru / Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos. Lima, Peru / Division of Rheumatology, Immunity and Inflammation. Brigham and Women’s Hospital, Harvard Medical School. Boston, Massachusetts, USA. |
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Lopez, KattyaArriaga Gutiérrez, María BelenAliaga, Juan G.Barreda, Nadia M.Sanabria, Oswaldo M.Huang, Chuan-ChinZhang, ZibiaoLa Guardia, Ruth Garcia deLecca, LeonidCarvalho, Ana Cristina CalçadaKritski, Afrânio L.Calderon, Roger I.2021-08-24T13:00:00Z2021-08-24T13:00:00Z2021LOPEZ, Katia et al. Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru. Plos One, v. 16, n. 1, e0243184, 14 p, Jan. 2021.1932-6203https://www.arca.fiocruz.br/handle/icict/4871410.1371/journal.pone.0243184engPublic Library of ScienceMycobacterium linhagens de tuberculoseDisglicemiaPacientesTuberculoseNorte de LimaPeruMycobacterium tuberculosis lineagesTuberculosisPatientsDysglycemiaNorth LImaPeruDysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peruinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSocios En Salud Sucursal Peru, Lima, Peru / Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos. Lima, Peru / Division of Rheumatology, Immunity and Inflammation. Brigham and Women’s Hospital, Harvard Medical School. Boston, Massachusetts, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil.Socios En Salud Sucursal Peru, Lima, Peru.Socios En Salud Sucursal Peru, Lima, Peru.Socios En Salud Sucursal Peru, Lima, Peru.Division of Global Health Equity, Brigham and Women’s Hospita. Boston, Massachusetts, USA.Department of Global Health and Social Medicine, Harvard Medical Schoo. Boston, Massachusetts, USA.Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos. Lima, Peru.Socios En Salud Sucursal Peru, Lima, Peru.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovacões em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, Rj, Brasil.Socios En Salud Sucursal Peru, Lima, Peru / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, Rj, Brasil.This study was performed to investigate the role of dysglycemia on the genetic diversity of Mycobacterium tuberculosis (MTB) among pulmonary tuberculosis (TB) patients to build scientific evidence about the possible mechanisms of TB transmission. MTB isolates obtained of patients affected by pulmonary tuberculosis from health care facilities of North Lima—Peru, were analyzed using whole genome sequencing and 24-locus mycobacterial interspersed repetitive-unit -variable-number tandem repeats (MIRU-VNTR). Subsequently, clinical and epidemiological characteristics were associated with clustering, lineages and comorbid conditions. The analysis carried out 112 pulmonary TB patients from various health centers in North Lima, 17 (15%) had diabetes mellitus (DM) and 33 (29%) had pre diabetes (PDM). Latin American-Mediterranean, Haarlem and Beijing were the most fre quent MTB lineages found in those patients. Previous TB (adjusted odds ratio [aOR] = 3.65; 95%CI: 1.32–17.81), age (aOR = 1.12; 95%CI: 1.03–1.45) and Beijing lineage (aOR = 3.53; 95%CI: 1.08–13.2) were associated with TB-DM comorbidity. Alcoholism (aOR = 2.92; 95% CI: 1.10–8.28), age (aOR = 1.05; 95%CI: 1.03–1.12) and Haarlem lineage (aOR = 2.54; 95%CI: 1.04–6.51) were associated with TB-PDM comorbidity. Beijing and Haarlem line ages were independently associated with TB-DM and TB-PDM comorbidities, respectively. Although these findings may be surprising, we must be cautious to suggest that dysglycemia could be associated with a highly clustering and predisposition of MTB lineages related to a serious impact on the severity of TB disease, which requires further research.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48714/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAnaCristina_Carvalho_etal_IOC_2021.pdfAnaCristina_Carvalho_etal_IOC_2021.pdfapplication/pdf1784245https://www.arca.fiocruz.br/bitstream/icict/48714/2/AnaCristina_Carvalho_etal_IOC_2021.pdf35c853b055aaf6e103e05fb468cb6a81MD52TEXTAnaCristina_Carvalho_etal_IOC_2021.pdf.txtAnaCristina_Carvalho_etal_IOC_2021.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru |
| title |
Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru |
| spellingShingle |
Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru Lopez, Kattya Mycobacterium linhagens de tuberculose Disglicemia Pacientes Tuberculose Norte de Lima Peru Mycobacterium tuberculosis lineages Tuberculosis Patients Dysglycemia North LIma Peru |
| title_short |
Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru |
| title_full |
Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru |
| title_fullStr |
Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru |
| title_full_unstemmed |
Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru |
| title_sort |
Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru |
| author |
Lopez, Kattya |
| author_facet |
Lopez, Kattya Arriaga Gutiérrez, María Belen Aliaga, Juan G. Barreda, Nadia M. Sanabria, Oswaldo M. Huang, Chuan-Chin Zhang, Zibiao La Guardia, Ruth Garcia de Lecca, Leonid Carvalho, Ana Cristina Calçada Kritski, Afrânio L. Calderon, Roger I. |
| author_role |
author |
| author2 |
Arriaga Gutiérrez, María Belen Aliaga, Juan G. Barreda, Nadia M. Sanabria, Oswaldo M. Huang, Chuan-Chin Zhang, Zibiao La Guardia, Ruth Garcia de Lecca, Leonid Carvalho, Ana Cristina Calçada Kritski, Afrânio L. Calderon, Roger I. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lopez, Kattya Arriaga Gutiérrez, María Belen Aliaga, Juan G. Barreda, Nadia M. Sanabria, Oswaldo M. Huang, Chuan-Chin Zhang, Zibiao La Guardia, Ruth Garcia de Lecca, Leonid Carvalho, Ana Cristina Calçada Kritski, Afrânio L. Calderon, Roger I. |
| dc.subject.other.pt_BR.fl_str_mv |
Mycobacterium linhagens de tuberculose Disglicemia Pacientes Tuberculose Norte de Lima Peru |
| topic |
Mycobacterium linhagens de tuberculose Disglicemia Pacientes Tuberculose Norte de Lima Peru Mycobacterium tuberculosis lineages Tuberculosis Patients Dysglycemia North LIma Peru |
| dc.subject.en.pt_BR.fl_str_mv |
Mycobacterium tuberculosis lineages Tuberculosis Patients Dysglycemia North LIma Peru |
| description |
Socios En Salud Sucursal Peru, Lima, Peru / Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos. Lima, Peru / Division of Rheumatology, Immunity and Inflammation. Brigham and Women’s Hospital, Harvard Medical School. Boston, Massachusetts, USA. |
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2021 |
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2021-08-24T13:00:00Z |
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2021-08-24T13:00:00Z |
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2021 |
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info:eu-repo/semantics/article |
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LOPEZ, Katia et al. Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru. Plos One, v. 16, n. 1, e0243184, 14 p, Jan. 2021. |
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https://www.arca.fiocruz.br/handle/icict/48714 |
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1932-6203 |
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10.1371/journal.pone.0243184 |
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LOPEZ, Katia et al. Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru. Plos One, v. 16, n. 1, e0243184, 14 p, Jan. 2021. 1932-6203 10.1371/journal.pone.0243184 |
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