The forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden country
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16187 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobacterias. Rio de Janeiro, RJ, Brasil. |
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Oelemann, Maranibia CardosoGomes, Harrison M.Willery, EvePossuelo, LiaLima, Karla Valéria BatistaAllix-Béguec, CarolineLocht, CamilleGoguet de la Salmonière, Yves-Olivier L.Gutierrez, Maria CristinaSuffys, PhilipSupply, Philip2016-10-11T14:39:21Z2016-10-11T14:39:21Z2011OELEMANN, Maranibia Cardoso; et al. The Forest behind the Tree: Phylogenetic Exploration of a Dominant Mycobacterium tuberculosis Strain Lineage from a High Tuberculosis Burden Country. Plos One, v.6, n.3, 10p, Mar. 2011.1932-6203https://www.arca.fiocruz.br/handle/icict/1618710.1371/journal.pone.0018256engPublic Library of ScienceMycobacterium tuberculosisLinhagemTuberculoseFilogenéticaBrasilMycobacterium tuberculosisLineagePhylogeneticTuberculosisBrazilThe forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden countryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobacterias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobacterias. Rio de Janeiro, RJ, Brasil.INSERM U1019, Lille, France. CNRS UMR 8204, Lille, France. Univ Lille Nord de France, Lille, France. Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France.Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.Instituto Evandro Chagas. Belém, PA, Brasil.INSERM U1019, Lille, France. CNRS UMR 8204, Lille, France. Univ Lille Nord de France, Lille, France. Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France.INSERM U1019, Lille, France. CNRS UMR 8204, Lille, France. Univ Lille Nord de France, Lille, France. Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France.Institut Pasteur. Department of Infection and Epidemiology. Paris, France.INSERM U1019, Lille, France. CNRS UMR 8204, Lille, France. Univ Lille Nord de France, Lille, France. Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France / Institut Pasteur. Department of Infection and Epidemiology. Paris, France..Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobacterias. Rio de Janeiro, RJ, Brasil.INSERM U1019, Lille, France. CNRS UMR 8204, Lille, France. Univ Lille Nord de France, Lille, France. Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France.Background: Genotyping of Mycobacterium tuberculosis isolates is a powerful tool for epidemiological control of tuberculosis (TB) and phylogenetic exploration of the pathogen. Standardized PCR-based typing, based on 15 to 24 mycobacterial interspersed repetitive unit-variable number of tandem repeat (MIRU-VNTR) loci combined with spoligotyping, has been shown to have adequate resolution power for tracing TB transmission and to be useful for predicting diverse strain lineages in European settings. Its informative value needs to be tested in high TB-burden countries, where the use of genotyping is often complicated by dominance of geographically specific, genetically homogeneous strain lineages. Methodology/Principal Findings: We tested this genotyping system for molecular epidemiological analysis of 369 M. tuberculosis isolates from 3 regions of Brazil, a high TB-burden country. Deligotyping, targeting 43 large sequence polymorphisms (LSPs), and the MIRU-VNTRplus identification database were used to assess phylogenetic predictions. High congruence between the different typing results consistently revealed the countrywide supremacy of the Latin-American- Mediterranean (LAM) lineage, comprised of three main branches. In addition to an already known RDRio branch, at least one other branch characterized by a phylogenetically informative LAM3 spoligo-signature seems to be globally distributed beyond Brazil. Nevertheless, by distinguishing 321 genotypes in this strain population, combined MIRU-VNTR typing and spoligotyping demonstrated the presence of multiple distinct clones. The use of 15 to 24 loci discriminated 21 to 25% more strains within the LAM lineage, compared to a restricted lineage-specific locus set suggested to be used after SNP analysis. Noteworthy, 23 of the 28 molecular clusters identified were exclusively composed of patient isolates from a same region, consistent with expected patterns of mostly local TB transmission. Conclusions/Significance: Standard MIRU-VNTR typing combined with spoligotyping can reveal epidemiologically meaningful clonal diversity behind a dominant M. tuberculosis strain lineage in a high TB-burden country and is useful to explore international phylogenetical ramifications.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16187/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALphylip_suffys_etal_IOC-2011.pdfphylip_suffys_etal_IOC-2011.pdfapplication/pdf1079097https://www.arca.fiocruz.br/bitstream/icict/16187/2/phylip_suffys_etal_IOC-2011.pdf9d1dadeff2a0a0133caa7620b18e82bfMD52TEXTphylip_suffys_etal_IOC-2011.pdf.txtphylip_suffys_etal_IOC-2011.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
The forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden country |
| title |
The forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden country |
| spellingShingle |
The forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden country Oelemann, Maranibia Cardoso Mycobacterium tuberculosis Linhagem Tuberculose Filogenética Brasil Mycobacterium tuberculosis Lineage Phylogenetic Tuberculosis Brazil |
| title_short |
The forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden country |
| title_full |
The forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden country |
| title_fullStr |
The forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden country |
| title_full_unstemmed |
The forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden country |
| title_sort |
The forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden country |
| author |
Oelemann, Maranibia Cardoso |
| author_facet |
Oelemann, Maranibia Cardoso Gomes, Harrison M. Willery, Eve Possuelo, Lia Lima, Karla Valéria Batista Allix-Béguec, Caroline Locht, Camille Goguet de la Salmonière, Yves-Olivier L. Gutierrez, Maria Cristina Suffys, Philip Supply, Philip |
| author_role |
author |
| author2 |
Gomes, Harrison M. Willery, Eve Possuelo, Lia Lima, Karla Valéria Batista Allix-Béguec, Caroline Locht, Camille Goguet de la Salmonière, Yves-Olivier L. Gutierrez, Maria Cristina Suffys, Philip Supply, Philip |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oelemann, Maranibia Cardoso Gomes, Harrison M. Willery, Eve Possuelo, Lia Lima, Karla Valéria Batista Allix-Béguec, Caroline Locht, Camille Goguet de la Salmonière, Yves-Olivier L. Gutierrez, Maria Cristina Suffys, Philip Supply, Philip |
| dc.subject.other.pt_BR.fl_str_mv |
Mycobacterium tuberculosis Linhagem Tuberculose Filogenética Brasil |
| topic |
Mycobacterium tuberculosis Linhagem Tuberculose Filogenética Brasil Mycobacterium tuberculosis Lineage Phylogenetic Tuberculosis Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
Mycobacterium tuberculosis Lineage Phylogenetic Tuberculosis Brazil |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobacterias. Rio de Janeiro, RJ, Brasil. |
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2011 |
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2011 |
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2016-10-11T14:39:21Z |
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2016-10-11T14:39:21Z |
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OELEMANN, Maranibia Cardoso; et al. The Forest behind the Tree: Phylogenetic Exploration of a Dominant Mycobacterium tuberculosis Strain Lineage from a High Tuberculosis Burden Country. Plos One, v.6, n.3, 10p, Mar. 2011. |
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https://www.arca.fiocruz.br/handle/icict/16187 |
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1932-6203 |
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10.1371/journal.pone.0018256 |
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OELEMANN, Maranibia Cardoso; et al. The Forest behind the Tree: Phylogenetic Exploration of a Dominant Mycobacterium tuberculosis Strain Lineage from a High Tuberculosis Burden Country. Plos One, v.6, n.3, 10p, Mar. 2011. 1932-6203 10.1371/journal.pone.0018256 |
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