Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47896 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. |
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Oliveira, Maria Talita Pacheco deCoutinho, Diego de SáGuterres, Sílvia StanisçuaskiPohlmann, Adriana RaffinSilva, Patrícia Machado Rodrigues eMartins, Marco AurélioBernardi, Andressa2021-06-28T13:54:16Z2021-06-28T13:54:16Z2021OLIVEIRA, Maria Talita Pacheco de et al. Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice. Pharmaceutics, v. 13, n.683, 17 p, May 2021.1999-4923https://www.arca.fiocruz.br/handle/icict/4789610.3390/pharmaceuthics13050683engMDPILesão pulmonar agudaSíndrome do desconforto respiratório agudoInflamaçãoReceptores de LipopolissacarídeosResveratrolAcute lung injuryAcute respiratory distress syndromeInflammationLPSResveratrolNanocarriersReceptores de LipopolissacarídeosResveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Programa de Pós-Graduação em Ciências Farmacêuticas. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Programa de Pós-Graduação em Ciências Farmacêuticas. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Instituto de Química. Departamento de Química Orgânica. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are inflammatory and oxidative imbalance lung conditions with no successful pharmacological therapy and a high mortality rate. Resveratrol (RSV) is a plant-derived stilbene that presents anti-inflammatory and an tioxidant effects. However, its therapeutic application remains limited due to its poor bioavailability, which can be solved by the use of nanocarriers. Previously, we demonstrated that nanoencapsulated RSV (RSV-LNC) pre-treatment, performed 4 h before lipopolysaccharide (LPS) stimulation in mice, increased its anti-inflammatory properties. In this study, we evaluated the anti-inflammatory and antioxidant effects, and lung distribution of RSV-LNCs administered therapeutically (6 h post LPS exposure) in a lung injury mouse model. The results showed that RSV-LNCs posttreatment improved lung function and diminished pulmonary inflammation. Moreover, RSV-LNC treatment enhanced the antioxidant catalase level together with a decrease in the oxidative biomarker in mouse lungs, which was accompanied by an increase in pulmonary Nrf2 antioxidant expression. Finally, the presence of RSV in lung tissue was significantly detected when mice received RSV-LNCs but not when they received RSV in its free form. Together, our results confirm that RSV nanoencapsulation promotes an increase in RSV bioavailability, enhancing its therapeutic effects in an LPS-induced lung injury model.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/47896/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMariaTalitaP_Oliveira_etal_IOC_2021.pdfMariaTalitaP_Oliveira_etal_IOC_2021.pdfapplication/pdf6118306https://www.arca.fiocruz.br/bitstream/icict/47896/2/MariaTalitaP_Oliveira_etal_IOC_2021.pdf49f3c7e482b121fe322402f1b9cb044cMD52TEXTMariaTalitaP_Oliveira_etal_IOC_2021.pdf.txtMariaTalitaP_Oliveira_etal_IOC_2021.pdf.txtExtracted texttext/plain59919https://www.arca.fiocruz.br/bitstream/icict/47896/3/MariaTalitaP_Oliveira_etal_IOC_2021.pdf.txt21262796482cd5cc579897ab558aea9bMD53icict/478962021-06-29 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| dc.title.pt_BR.fl_str_mv |
Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice |
| title |
Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice |
| spellingShingle |
Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice Oliveira, Maria Talita Pacheco de Lesão pulmonar aguda Síndrome do desconforto respiratório agudo Inflamação Receptores de Lipopolissacarídeos Resveratrol Acute lung injury Acute respiratory distress syndrome Inflammation LPS Resveratrol Nanocarriers Receptores de Lipopolissacarídeos |
| title_short |
Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice |
| title_full |
Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice |
| title_fullStr |
Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice |
| title_full_unstemmed |
Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice |
| title_sort |
Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice |
| author |
Oliveira, Maria Talita Pacheco de |
| author_facet |
Oliveira, Maria Talita Pacheco de Coutinho, Diego de Sá Guterres, Sílvia Stanisçuaski Pohlmann, Adriana Raffin Silva, Patrícia Machado Rodrigues e Martins, Marco Aurélio Bernardi, Andressa |
| author_role |
author |
| author2 |
Coutinho, Diego de Sá Guterres, Sílvia Stanisçuaski Pohlmann, Adriana Raffin Silva, Patrícia Machado Rodrigues e Martins, Marco Aurélio Bernardi, Andressa |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Maria Talita Pacheco de Coutinho, Diego de Sá Guterres, Sílvia Stanisçuaski Pohlmann, Adriana Raffin Silva, Patrícia Machado Rodrigues e Martins, Marco Aurélio Bernardi, Andressa |
| dc.subject.other.pt_BR.fl_str_mv |
Lesão pulmonar aguda Síndrome do desconforto respiratório agudo Inflamação Receptores de Lipopolissacarídeos Resveratrol |
| topic |
Lesão pulmonar aguda Síndrome do desconforto respiratório agudo Inflamação Receptores de Lipopolissacarídeos Resveratrol Acute lung injury Acute respiratory distress syndrome Inflammation LPS Resveratrol Nanocarriers Receptores de Lipopolissacarídeos |
| dc.subject.en.pt_BR.fl_str_mv |
Acute lung injury Acute respiratory distress syndrome Inflammation LPS Resveratrol Nanocarriers |
| dc.subject.decs.pt_BR.fl_str_mv |
Receptores de Lipopolissacarídeos |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. |
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2021 |
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2021-06-28T13:54:16Z |
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2021-06-28T13:54:16Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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OLIVEIRA, Maria Talita Pacheco de et al. Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice. Pharmaceutics, v. 13, n.683, 17 p, May 2021. |
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https://www.arca.fiocruz.br/handle/icict/47896 |
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1999-4923 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/pharmaceuthics13050683 |
| identifier_str_mv |
OLIVEIRA, Maria Talita Pacheco de et al. Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice. Pharmaceutics, v. 13, n.683, 17 p, May 2021. 1999-4923 10.3390/pharmaceuthics13050683 |
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