Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)

Detalhes bibliográficos
Autor(a) principal: Rangel, Alba Lucínia Peixoto
Data de Publicação: 2009
Outros Autores: Miller, E Nancy, Castellucci, Léa, Jamieson, Sarra E, Peixe, Ricardo Guerra, Elias, Liliani de Souza, Oliveira, Rodrigo Correa, Bahia-Oliveira, Lílian MG, Blackwel, Jenefer M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58544
Resumo: Universidade Estadual do Norte Fluminense Darcy Ribeiro. Campos dos Goytacazes, RJ, Brasil/Cambridge Institute for Medical Research and Department of Medicine. University of Cambridge School of Clinical Medicine. Cambridge, UK/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
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spelling Rangel, Alba Lucínia PeixotoMiller, E NancyCastellucci, LéaJamieson, Sarra EPeixe, Ricardo GuerraElias, Liliani de SouzaOliveira, Rodrigo CorreaBahia-Oliveira, Lílian MGBlackwel, Jenefer M2023-05-22T13:02:56Z2023-05-22T13:02:56Z2009RANGEL, Alba Lucínia Peixoto et al. Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9). Mem Inst Oswaldo Cruz, v. 104, n. 8, p. 1187-1190, 2009. DOI: 10.1590/S0074-027620090008000190074-0276https://www.arca.fiocruz.br/handle/icict/5854410.1590/S0074-02762009000800019engFundação Oswaldo CruzCandidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual do Norte Fluminense Darcy Ribeiro. Campos dos Goytacazes, RJ, Brasil/Cambridge Institute for Medical Research and Department of Medicine. University of Cambridge School of Clinical Medicine. Cambridge, UK/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilCambridge Institute for Medical Research and Department of Medicine. University of Cambridge School of Clinical Medicine. Cambridge, UKCambridge Institute for Medical Research and Department of Medicine. University of Cambridge School of Clinical Medicine. Cambridge, UK/Universidade Federal da Bahia. Salvador, BA, BrasilCambridge Institute for Medical Research and Department of Medicine. University of Cambridge School of Clinical Medicine. Cambridge, UK/Telethon Institute for Child Health Research. Centre for Child Health Research. The University of Western Australia. Subiaco, AustraliaUniversidade Estadual do Norte Fluminense Darcy Ribeiro. Campos dos Goytacazes, RJ, BrasilUniversidade Estadual do Norte Fluminense Darcy Ribeiro. Campos dos Goytacazes, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilUniversidade Estadual do Norte Fluminense Darcy Ribeiro. Campos dos Goytacazes, RJ, BrasilTelethon Institute for Child Health Research. Centre for Child Health Research. The University of Western Australia. Subiaco, AustraliaToxoplasma gondii infection is an important mediator of ocular disease in Brazil more frequently than reported from elsewhere. Infection and pathology are characterized by a strong proinflammatory response which in mice is triggered by interaction of the parasite with the toll-like receptor (TLR)/MyD88 pathway. A powerful way to identify the role of TLRs in humans is to determine whether polymorphisms at these loci influence susceptibility to T. gondii-mediated pathologies. Here we report on a small family-based study (60 families; 68 affected offspring) undertaken in Brazil which was powered for large effect sizes using single nucleotide polymorphisms with minor alleles frequencies > 0.3. Of markers in TLR2, TLR5 and TLR9 that met these criteria, we found an association Family Based Association Tests [(FBAT) Z score = 4.232; p = 1.5 x 10(-5); p(corrected) = 1.2 x 10(-4)] between the C allele (frequency = 0.424; odds ratio = 7; 95% confidence interval 1.6-30.8) of rs352140 at TLR9 and toxoplasmic retinochoroiditis in Brazil. This supports the hypothesis that direct interaction between T. gondii and TLR9 may trigger proinflammatory responses that lead to severe pathologies such as the ocular disease that is associated with this infection in Braziltoxoplasmosisgenetic polymorphismstoll-like receptorstoxoplasmic retinochoroiditisBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCandidate gene analysis of ocular toxoplasmosis in Brazil.pdfCandidate gene analysis of ocular toxoplasmosis in Brazil.pdfapplication/pdf237591https://www.arca.fiocruz.br/bitstream/icict/58544/2/Candidate%20gene%20analysis%20of%20ocular%20toxoplasmosis%20in%20Brazil.pdf33d3571573b1c7dced2b032ae636a14dMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/58544/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/585442023-05-22 10:02:56.962oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-22T13:02:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
title Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
spellingShingle Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
Rangel, Alba Lucínia Peixoto
toxoplasmosis
genetic polymorphisms
toll-like receptors
toxoplasmic retinochoroiditis
Brazil
title_short Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
title_full Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
title_fullStr Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
title_full_unstemmed Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
title_sort Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
author Rangel, Alba Lucínia Peixoto
author_facet Rangel, Alba Lucínia Peixoto
Miller, E Nancy
Castellucci, Léa
Jamieson, Sarra E
Peixe, Ricardo Guerra
Elias, Liliani de Souza
Oliveira, Rodrigo Correa
Bahia-Oliveira, Lílian MG
Blackwel, Jenefer M
author_role author
author2 Miller, E Nancy
Castellucci, Léa
Jamieson, Sarra E
Peixe, Ricardo Guerra
Elias, Liliani de Souza
Oliveira, Rodrigo Correa
Bahia-Oliveira, Lílian MG
Blackwel, Jenefer M
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rangel, Alba Lucínia Peixoto
Miller, E Nancy
Castellucci, Léa
Jamieson, Sarra E
Peixe, Ricardo Guerra
Elias, Liliani de Souza
Oliveira, Rodrigo Correa
Bahia-Oliveira, Lílian MG
Blackwel, Jenefer M
dc.subject.en.en_US.fl_str_mv toxoplasmosis
genetic polymorphisms
toll-like receptors
toxoplasmic retinochoroiditis
Brazil
topic toxoplasmosis
genetic polymorphisms
toll-like receptors
toxoplasmic retinochoroiditis
Brazil
description Universidade Estadual do Norte Fluminense Darcy Ribeiro. Campos dos Goytacazes, RJ, Brasil/Cambridge Institute for Medical Research and Department of Medicine. University of Cambridge School of Clinical Medicine. Cambridge, UK/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2023-05-22T13:02:56Z
dc.date.available.fl_str_mv 2023-05-22T13:02:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv RANGEL, Alba Lucínia Peixoto et al. Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9). Mem Inst Oswaldo Cruz, v. 104, n. 8, p. 1187-1190, 2009. DOI: 10.1590/S0074-02762009000800019
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58544
dc.identifier.issn.en_US.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762009000800019
identifier_str_mv RANGEL, Alba Lucínia Peixoto et al. Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9). Mem Inst Oswaldo Cruz, v. 104, n. 8, p. 1187-1190, 2009. DOI: 10.1590/S0074-02762009000800019
0074-0276
10.1590/S0074-02762009000800019
url https://www.arca.fiocruz.br/handle/icict/58544
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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