Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)

Detalhes bibliográficos
Autor(a) principal: Rangel, Alba L. Peixoto
Data de Publicação: 2010
Outros Autores: Miller, E. Nancy, Castellucci, Léa, Jamieson, Sarra E., Peixe, Ricardo Guerra, Elias, Liliani de Souza, Oliveira, Rodrigo Correa, Oliveira, Lílian M. G. Bahia, Blackwell, Jenefer M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13785
Resumo: p. 1187-1190
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spelling Rangel, Alba L. PeixotoMiller, E. NancyCastellucci, LéaJamieson, Sarra E.Peixe, Ricardo GuerraElias, Liliani de SouzaOliveira, Rodrigo CorreaOliveira, Lílian M. G. BahiaBlackwell, Jenefer M.2013-11-19T20:32:26Z2013-11-19T20:32:26Z20100074-0276http://repositorio.ufba.br/ri/handle/ri/13785v. 104, n. 8p. 1187-1190Toxoplasma gondii infection is an important mediator of ocular disease in Brazil more frequently than reported from elsewhere. Infection and pathology are characterized by a strong proinflammatory response which in mice is triggered by interaction of the parasite with the toll-like receptor (TLR)/MyD88 pathway. A powerful way to identify the role of TLRs in humans is to determine whether polymorphisms at these loci influence susceptibility to T. gondii-mediated pathologies. Here we report on a small family-based study (60 families; 68 affected offspring) undertaken in Brazil which was powered for large effect sizes using single nucleotide polymorphisms with minor alleles frequencies > 0.3. Of markers in TLR2, TLR5 and TLR9 that met these criteria, we found an association Family Based Association Tests [(FBAT) Z score = 4.232; p = 1.5 x 10-5; pcorrected = 1.2 x 10-4] between the C allele (frequency = 0.424; odds ratio = 7; 95% confidence interval 1.6-30.8) of rs352140 at TLR9 and toxoplasmic retinochoroiditis in Brazil. This supports the hypothesis that direct interaction between T. gondii and TLR9 may trigger proinflammatory responses that lead to severe pathologies such as the ocular disease that is associated with this infection in Brazil.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-09-17T14:45:30Z No. of bitstreams: 1 0074-0276200900080001.pdf: 205952 bytes, checksum: ceb33790c5dff2b1b875c40a3422f7ad (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-19T20:32:26Z (GMT) No. of bitstreams: 1 0074-0276200900080001.pdf: 205952 bytes, checksum: ceb33790c5dff2b1b875c40a3422f7ad (MD5)Made available in DSpace on 2013-11-19T20:32:26Z (GMT). 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dc.title.pt_BR.fl_str_mv Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
dc.title.alternative.pt_BR.fl_str_mv Memórias do Instituto Oswaldo Cruz
title Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
spellingShingle Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
Rangel, Alba L. Peixoto
Toxoplasmosis
Genetic polymorphisms
Toll-like receptors
Toxoplasmic retinochoroiditis
Brazil
title_short Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
title_full Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
title_fullStr Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
title_full_unstemmed Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
title_sort Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
author Rangel, Alba L. Peixoto
author_facet Rangel, Alba L. Peixoto
Miller, E. Nancy
Castellucci, Léa
Jamieson, Sarra E.
Peixe, Ricardo Guerra
Elias, Liliani de Souza
Oliveira, Rodrigo Correa
Oliveira, Lílian M. G. Bahia
Blackwell, Jenefer M.
author_role author
author2 Miller, E. Nancy
Castellucci, Léa
Jamieson, Sarra E.
Peixe, Ricardo Guerra
Elias, Liliani de Souza
Oliveira, Rodrigo Correa
Oliveira, Lílian M. G. Bahia
Blackwell, Jenefer M.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rangel, Alba L. Peixoto
Miller, E. Nancy
Castellucci, Léa
Jamieson, Sarra E.
Peixe, Ricardo Guerra
Elias, Liliani de Souza
Oliveira, Rodrigo Correa
Oliveira, Lílian M. G. Bahia
Blackwell, Jenefer M.
dc.subject.por.fl_str_mv Toxoplasmosis
Genetic polymorphisms
Toll-like receptors
Toxoplasmic retinochoroiditis
Brazil
topic Toxoplasmosis
Genetic polymorphisms
Toll-like receptors
Toxoplasmic retinochoroiditis
Brazil
description p. 1187-1190
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-11-19T20:32:26Z
dc.date.available.fl_str_mv 2013-11-19T20:32:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13785
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.number.pt_BR.fl_str_mv v. 104, n. 8
identifier_str_mv 0074-0276
v. 104, n. 8
url http://repositorio.ufba.br/ri/handle/ri/13785
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0074-02762009000800019
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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