Molecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within?

Detalhes bibliográficos
Autor(a) principal: Righy, Cássia
Data de Publicação: 2016
Outros Autores: Bozza, Marcelo T., Oliveira, Marcus F., Bozza, Fernando A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32409
Resumo: Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.
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spelling Righy, CássiaBozza, Marcelo T.Oliveira, Marcus F.Bozza, Fernando A.2019-04-08T14:34:35Z2019-04-08T14:34:35Z2016RIGHY, Cássia et al. Molecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within? Current Neuropharmacology, v. 14, n. 4, 392-402, 2016.1570-159Xhttps://www.arca.fiocruz.br/handle/icict/3240910.2174/1570159X146661512301100581875-6190engBentham Science PublishersMolecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Laboratório de Inflamação e Imunidade. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Laboratório de Bioquímica de Resposta ao Estresse. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem. Laboratório de Inflamação e Metabolismo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brasil.Hemorrhagic stroke is a disease with high incidence and mortality rates. In addition to the mass lesions that result from hemorrhagic stroke, substances such as the blood-derived products (BDP) (hemoglobin (Hb), heme and iron) induce a potent inflammatory response and exert direct toxic effects on neurons, astrocytes, and microglia. In the present review, we discuss the mechanisms of brain injury secondary to hemorrhagic stroke, focusing on the involvement of BDP as major players of cellular redox imbalance, inflammation, and glutamate excitotoxicity. Potential natural mechanisms of protection against free Hb and heme such as haptoglobin and hemopexin, respectively, are highlighted. We finally discuss the experimental and clinical trials targeting free iron and heme scavenging as well as inflammation, as potential new therapies to minimize the devastating effects of hemorrhagic stroke on brain structure and function.HemeHemorrhagic strokeInflammatory responseIntracranial bleedingIronReactive oxygen species,Subarachnoid hemorrhageinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32409/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Righy_Cássia_etal_INI_2016.pdfve_Righy_Cássia_etal_INI_2016.pdfapplication/pdf2680524https://www.arca.fiocruz.br/bitstream/icict/32409/2/ve_Righy_C%c3%a1ssia_etal_INI_2016.pdfd2cdd36b61fc85de817e7482ec709cf4MD52TEXTve_Righy_Cássia_etal_INI_2016.pdf.txtve_Righy_Cássia_etal_INI_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Molecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within?
title Molecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within?
spellingShingle Molecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within?
Righy, Cássia
Heme
Hemorrhagic stroke
Inflammatory response
Intracranial bleeding
Iron
Reactive oxygen species,
Subarachnoid hemorrhage
title_short Molecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within?
title_full Molecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within?
title_fullStr Molecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within?
title_full_unstemmed Molecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within?
title_sort Molecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within?
author Righy, Cássia
author_facet Righy, Cássia
Bozza, Marcelo T.
Oliveira, Marcus F.
Bozza, Fernando A.
author_role author
author2 Bozza, Marcelo T.
Oliveira, Marcus F.
Bozza, Fernando A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Righy, Cássia
Bozza, Marcelo T.
Oliveira, Marcus F.
Bozza, Fernando A.
dc.subject.en.pt_BR.fl_str_mv Heme
Hemorrhagic stroke
Inflammatory response
Intracranial bleeding
Iron
Reactive oxygen species,
Subarachnoid hemorrhage
topic Heme
Hemorrhagic stroke
Inflammatory response
Intracranial bleeding
Iron
Reactive oxygen species,
Subarachnoid hemorrhage
description Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-04-08T14:34:35Z
dc.date.available.fl_str_mv 2019-04-08T14:34:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RIGHY, Cássia et al. Molecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within? Current Neuropharmacology, v. 14, n. 4, 392-402, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32409
dc.identifier.issn.pt_BR.fl_str_mv 1570-159X
dc.identifier.doi.none.fl_str_mv 10.2174/1570159X14666151230110058
dc.identifier.eissn.none.fl_str_mv 1875-6190
identifier_str_mv RIGHY, Cássia et al. Molecular, cellular and clinical aspects of intracerebral hemorrhage: are the enemies within? Current Neuropharmacology, v. 14, n. 4, 392-402, 2016.
1570-159X
10.2174/1570159X14666151230110058
1875-6190
url https://www.arca.fiocruz.br/handle/icict/32409
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/32409/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/32409/2/ve_Righy_C%c3%a1ssia_etal_INI_2016.pdf
https://www.arca.fiocruz.br/bitstream/icict/32409/3/ve_Righy_C%c3%a1ssia_etal_INI_2016.pdf.txt
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