Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7652 |
Resumo: | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil |
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Campos, José Humberto OGomes, Heitor CarvalhodosSantos, Washington Luis ConradoCardeal, MauricioFerreira, Lydia Masako2014-05-23T19:30:15Z2014-05-23T19:30:15Z2008CAMPOS, J. H. O. et al. Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. Experimental and Toxicologic Pathology, v. 60, p. 449–452, 2008.0940-2993https://www.arca.fiocruz.br/handle/icict/7652:10.1016/j.etp.2008.02.004engElsevierEffect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilEscola Paulista de Medicina-UNIFESP. São Paulo, SP, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilEscola Paulista de Medicina-UNIFESP. São Paulo, SP, BrasilBackground: Tobacco use is associated with a high incidence of skin necrosis after surgery. The ideal timing for the cessation of tobacco use before plastic surgery has not, however, been precisely determined. The aim of this work was to define the ideal duration of nicotine withdrawal prior to random-pattern skin flap surgery in rats. Methods: Groups of 11 animals were subcutaneously injected with saline or nicotine (2 mg/kg) twice a day and subjected to random-pattern skin flap surgery according to the following protocol: Group I: continuously injected with saline 4 weeks before and 1 week after the surgery; Group II: injected with nicotine for 4 weeks until the day of the surgery; Group III: injected with nicotine for 4 weeks until one day before the surgery; Group IV: injected with nicotine for 4 weeks until 5 days before the surgery; Group V: injected with nicotine for 4 weeks until 10 days before the surgery; Group VI: continuously injected with nicotine for 4 weeks before and 1 week after the surgery. McFARLANE skin flaps were performed on the dorsal skin, and the rats were sacrificed 1 week after the surgery. Results: The necrotic area was smaller in group I (8.85 cm2) than in group II (12.15 cm2), III (12.88 cm2) and VI (14.84 cm2) (ANOVA po0.0001). There was no difference between groups I, IV (10.13 cm2) and V (9.27 cm2). Conclusions: In conclusion, 5 days before surgery was considered the ideal time for nicotine withdrawal in this experimental model.NicotineMcFARLANE skin flapsNecrosisTobaccoRatsNicotina/toxicidadeAgonistas Nicotínicos/toxicidadePele/efeitos de drogasRetalhos CirúrgicosSobrevivência de Tecidos/efeitos de drogasAnimaisModelos Animais de DoençasEsquema de MedicaçãoInjeções SubcutâneasNecroseNicotina/administração & dosagemAgonistas Nicotínicos/administração & dosagemRatosPele/patologiaRetalhos Cirúrgicos/patologiaSuspensão de Tratamentoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCAmpos JHO Effect of nicotine....pdfCAmpos JHO Effect of nicotine....pdfapplication/pdf164052https://www.arca.fiocruz.br/bitstream/icict/7652/1/CAmpos%20JHO%20Effect%20of%20nicotine....pdfe3bfbabefda33ff30afeef8533a5a3edMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7652/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCAmpos JHO Effect of nicotine....pdf.txtCAmpos JHO Effect of nicotine....pdf.txtExtracted texttext/plain14924https://www.arca.fiocruz.br/bitstream/icict/7652/5/CAmpos%20JHO%20Effect%20of%20nicotine....pdf.txta8e7c84ba1681959723e71f07a16670bMD55THUMBNAILCAmpos JHO Effect of nicotine....pdf.jpgCAmpos JHO Effect of nicotine....pdf.jpgGenerated Thumbnailimage/jpeg2325https://www.arca.fiocruz.br/bitstream/icict/7652/4/CAmpos%20JHO%20Effect%20of%20nicotine....pdf.jpg8e2cc902f48ebb18e8afb61b735ce6d7MD54icict/76522023-03-15 14:33:22.119oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. |
title |
Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. |
spellingShingle |
Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. Campos, José Humberto O Nicotine McFARLANE skin flaps Necrosis Tobacco Rats Nicotina/toxicidade Agonistas Nicotínicos/toxicidade Pele/efeitos de drogas Retalhos Cirúrgicos Sobrevivência de Tecidos/efeitos de drogas Animais Modelos Animais de Doenças Esquema de Medicação Injeções Subcutâneas Necrose Nicotina/administração & dosagem Agonistas Nicotínicos/administração & dosagem Ratos Pele/patologia Retalhos Cirúrgicos/patologia Suspensão de Tratamento |
title_short |
Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. |
title_full |
Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. |
title_fullStr |
Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. |
title_full_unstemmed |
Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. |
title_sort |
Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. |
author |
Campos, José Humberto O |
author_facet |
Campos, José Humberto O Gomes, Heitor Carvalho dosSantos, Washington Luis Conrado Cardeal, Mauricio Ferreira, Lydia Masako |
author_role |
author |
author2 |
Gomes, Heitor Carvalho dosSantos, Washington Luis Conrado Cardeal, Mauricio Ferreira, Lydia Masako |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Campos, José Humberto O Gomes, Heitor Carvalho dosSantos, Washington Luis Conrado Cardeal, Mauricio Ferreira, Lydia Masako |
dc.subject.en.pt_BR.fl_str_mv |
Nicotine McFARLANE skin flaps Necrosis Tobacco Rats |
topic |
Nicotine McFARLANE skin flaps Necrosis Tobacco Rats Nicotina/toxicidade Agonistas Nicotínicos/toxicidade Pele/efeitos de drogas Retalhos Cirúrgicos Sobrevivência de Tecidos/efeitos de drogas Animais Modelos Animais de Doenças Esquema de Medicação Injeções Subcutâneas Necrose Nicotina/administração & dosagem Agonistas Nicotínicos/administração & dosagem Ratos Pele/patologia Retalhos Cirúrgicos/patologia Suspensão de Tratamento |
dc.subject.decs.pt_BR.fl_str_mv |
Nicotina/toxicidade Agonistas Nicotínicos/toxicidade Pele/efeitos de drogas Retalhos Cirúrgicos Sobrevivência de Tecidos/efeitos de drogas Animais Modelos Animais de Doenças Esquema de Medicação Injeções Subcutâneas Necrose Nicotina/administração & dosagem Agonistas Nicotínicos/administração & dosagem Ratos Pele/patologia Retalhos Cirúrgicos/patologia Suspensão de Tratamento |
description |
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2014-05-23T19:30:15Z |
dc.date.available.fl_str_mv |
2014-05-23T19:30:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CAMPOS, J. H. O. et al. Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. Experimental and Toxicologic Pathology, v. 60, p. 449–452, 2008. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7652 |
dc.identifier.issn.none.fl_str_mv |
0940-2993 |
dc.identifier.doi.none.fl_str_mv |
:10.1016/j.etp.2008.02.004 |
identifier_str_mv |
CAMPOS, J. H. O. et al. Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. Experimental and Toxicologic Pathology, v. 60, p. 449–452, 2008. 0940-2993 :10.1016/j.etp.2008.02.004 |
url |
https://www.arca.fiocruz.br/handle/icict/7652 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Elsevier |
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Elsevier |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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