Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.

Detalhes bibliográficos
Autor(a) principal: Campos, José Humberto O
Data de Publicação: 2008
Outros Autores: Gomes, Heitor Carvalho, dosSantos, Washington Luis Conrado, Cardeal, Mauricio, Ferreira, Lydia Masako
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7652
Resumo: Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
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spelling Campos, José Humberto OGomes, Heitor CarvalhodosSantos, Washington Luis ConradoCardeal, MauricioFerreira, Lydia Masako2014-05-23T19:30:15Z2014-05-23T19:30:15Z2008CAMPOS, J. H. O. et al. Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. Experimental and Toxicologic Pathology, v. 60, p. 449–452, 2008.0940-2993https://www.arca.fiocruz.br/handle/icict/7652:10.1016/j.etp.2008.02.004engElsevierEffect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilEscola Paulista de Medicina-UNIFESP. São Paulo, SP, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilEscola Paulista de Medicina-UNIFESP. São Paulo, SP, BrasilBackground: Tobacco use is associated with a high incidence of skin necrosis after surgery. The ideal timing for the cessation of tobacco use before plastic surgery has not, however, been precisely determined. The aim of this work was to define the ideal duration of nicotine withdrawal prior to random-pattern skin flap surgery in rats. Methods: Groups of 11 animals were subcutaneously injected with saline or nicotine (2 mg/kg) twice a day and subjected to random-pattern skin flap surgery according to the following protocol: Group I: continuously injected with saline 4 weeks before and 1 week after the surgery; Group II: injected with nicotine for 4 weeks until the day of the surgery; Group III: injected with nicotine for 4 weeks until one day before the surgery; Group IV: injected with nicotine for 4 weeks until 5 days before the surgery; Group V: injected with nicotine for 4 weeks until 10 days before the surgery; Group VI: continuously injected with nicotine for 4 weeks before and 1 week after the surgery. McFARLANE skin flaps were performed on the dorsal skin, and the rats were sacrificed 1 week after the surgery. Results: The necrotic area was smaller in group I (8.85 cm2) than in group II (12.15 cm2), III (12.88 cm2) and VI (14.84 cm2) (ANOVA po0.0001). There was no difference between groups I, IV (10.13 cm2) and V (9.27 cm2). Conclusions: In conclusion, 5 days before surgery was considered the ideal time for nicotine withdrawal in this experimental model.NicotineMcFARLANE skin flapsNecrosisTobaccoRatsNicotina/toxicidadeAgonistas Nicotínicos/toxicidadePele/efeitos de drogasRetalhos CirúrgicosSobrevivência de Tecidos/efeitos de drogasAnimaisModelos Animais de DoençasEsquema de MedicaçãoInjeções SubcutâneasNecroseNicotina/administração & dosagemAgonistas Nicotínicos/administração & dosagemRatosPele/patologiaRetalhos Cirúrgicos/patologiaSuspensão de Tratamentoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCAmpos JHO Effect of nicotine....pdfCAmpos JHO Effect of nicotine....pdfapplication/pdf164052https://www.arca.fiocruz.br/bitstream/icict/7652/1/CAmpos%20JHO%20Effect%20of%20nicotine....pdfe3bfbabefda33ff30afeef8533a5a3edMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7652/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCAmpos JHO Effect of nicotine....pdf.txtCAmpos JHO Effect of nicotine....pdf.txtExtracted texttext/plain14924https://www.arca.fiocruz.br/bitstream/icict/7652/5/CAmpos%20JHO%20Effect%20of%20nicotine....pdf.txta8e7c84ba1681959723e71f07a16670bMD55THUMBNAILCAmpos JHO Effect of nicotine....pdf.jpgCAmpos JHO Effect of nicotine....pdf.jpgGenerated Thumbnailimage/jpeg2325https://www.arca.fiocruz.br/bitstream/icict/7652/4/CAmpos%20JHO%20Effect%20of%20nicotine....pdf.jpg8e2cc902f48ebb18e8afb61b735ce6d7MD54icict/76522023-03-15 14:33:22.119oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.
title Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.
spellingShingle Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.
Campos, José Humberto O
Nicotine
McFARLANE skin flaps
Necrosis
Tobacco
Rats
Nicotina/toxicidade
Agonistas Nicotínicos/toxicidade
Pele/efeitos de drogas
Retalhos Cirúrgicos
Sobrevivência de Tecidos/efeitos de drogas
Animais
Modelos Animais de Doenças
Esquema de Medicação
Injeções Subcutâneas
Necrose
Nicotina/administração & dosagem
Agonistas Nicotínicos/administração & dosagem
Ratos
Pele/patologia
Retalhos Cirúrgicos/patologia
Suspensão de Tratamento
title_short Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.
title_full Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.
title_fullStr Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.
title_full_unstemmed Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.
title_sort Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.
author Campos, José Humberto O
author_facet Campos, José Humberto O
Gomes, Heitor Carvalho
dosSantos, Washington Luis Conrado
Cardeal, Mauricio
Ferreira, Lydia Masako
author_role author
author2 Gomes, Heitor Carvalho
dosSantos, Washington Luis Conrado
Cardeal, Mauricio
Ferreira, Lydia Masako
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Campos, José Humberto O
Gomes, Heitor Carvalho
dosSantos, Washington Luis Conrado
Cardeal, Mauricio
Ferreira, Lydia Masako
dc.subject.en.pt_BR.fl_str_mv Nicotine
McFARLANE skin flaps
Necrosis
Tobacco
Rats
topic Nicotine
McFARLANE skin flaps
Necrosis
Tobacco
Rats
Nicotina/toxicidade
Agonistas Nicotínicos/toxicidade
Pele/efeitos de drogas
Retalhos Cirúrgicos
Sobrevivência de Tecidos/efeitos de drogas
Animais
Modelos Animais de Doenças
Esquema de Medicação
Injeções Subcutâneas
Necrose
Nicotina/administração & dosagem
Agonistas Nicotínicos/administração & dosagem
Ratos
Pele/patologia
Retalhos Cirúrgicos/patologia
Suspensão de Tratamento
dc.subject.decs.pt_BR.fl_str_mv Nicotina/toxicidade
Agonistas Nicotínicos/toxicidade
Pele/efeitos de drogas
Retalhos Cirúrgicos
Sobrevivência de Tecidos/efeitos de drogas
Animais
Modelos Animais de Doenças
Esquema de Medicação
Injeções Subcutâneas
Necrose
Nicotina/administração & dosagem
Agonistas Nicotínicos/administração & dosagem
Ratos
Pele/patologia
Retalhos Cirúrgicos/patologia
Suspensão de Tratamento
description Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2014-05-23T19:30:15Z
dc.date.available.fl_str_mv 2014-05-23T19:30:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CAMPOS, J. H. O. et al. Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. Experimental and Toxicologic Pathology, v. 60, p. 449–452, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7652
dc.identifier.issn.none.fl_str_mv 0940-2993
dc.identifier.doi.none.fl_str_mv :10.1016/j.etp.2008.02.004
identifier_str_mv CAMPOS, J. H. O. et al. Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. Experimental and Toxicologic Pathology, v. 60, p. 449–452, 2008.
0940-2993
:10.1016/j.etp.2008.02.004
url https://www.arca.fiocruz.br/handle/icict/7652
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron_str FIOCRUZ
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