Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1155/2013/742476 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/59433 |
Resumo: | Department of Biochemistry. University of Ilorin. Ilorin, Nigeria. |
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Adebayo, Joseph OluwatopeBalogun, E. A.Malomo, S. O.Soladoye, A. O.Olatunji, L. A.Kolawole, O. M.Oguntoye, O. S.Babatunde, A. S.Akinola, O. B.Aguiar, Anna Caroline CamposAndrade, Isabel Mayer deSouza, Nicolli Bellotti deKrettli, Antoniana Ursine2023-07-06T13:05:07Z2023-07-06T13:05:07Z2013ADEBAYO, Joseph Oluwatope et al. Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies. Evidence-Based Complementary and Alternative Medicine, v. 2013, p. 1-9, Article ID 742476, 2013.1741-427Xhttps://www.arca.fiocruz.br/handle/icict/5943310.1155/2013/742476engHindawiAntimalarial Activity of Cocos nucifera Husk Fibre: Further Studiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Biochemistry. University of Ilorin. Ilorin, Nigeria.Department of Biochemistry. University of Ilorin. Ilorin, Nigeria.Department of Biochemistry. University of Ilorin. Ilorin, Nigeria.Department of Physiology. University of Ilorin. Ilorin, Nigeria.Department of Physiology. University of Ilorin. Ilorin, Nigeria.Department of Microbiology. University of Ilorin. Ilorin, Nigeria.Department of Chemistry. University of Ilorin. Ilorin, Nigeria.Department of Hematology, University of Ilorin, Ilorin, Nigeria.Department of Anatomy. University of Ilorin. Ilorin, Nigeria.Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós Graduação em Medicina Molecular. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós Graduação em Medicina Molecular. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.In this study, the antimalarial and toxicity potentials of husk fibre extracts of five Nigerian varieties of Cocos nucifera were evaluated in vitro. The only active extract fraction, West African Tall (WAT) ethyl acetate extract fraction, was then evaluated for its phytochemical constituents, antimalarial and toxicity potentials at varying doses (31.25-500 mg/kg body weight) using various organ function indices. The results revealed that WAT ethyl acetate extract fraction (WATEAEF) contained alkaloids, tannins, and flavonoids and was active against Plasmodium falciparum W2 strain maintained in continuous culture, with a selectivity index of 30.3. The same extract fraction was active in vivo against Plasmodium berghei NK65, causing more than 50% reduction in parasitaemia on days 4 and 6 after inoculation at various doses administered. WATEAEF did not significantly alter (P > 0.05) function indices of the liver and cardiovascular system at all doses administered but significantly increased (P < 0.05) plasma creatinine concentration at 250 and 500 mg/Kg body weight compared to controls. The results of this study suggest that WATEAEF possesses antimalarial activity and may not adversely affect normal liver function nor predispose subjects to cardiovascular diseases but may impair normal kidney function at higher doses. Further studies are underway to isolate the active principles.Cocos nuciferaAntimalarial ActivityPlasmodium falciparum W2Plasmodium berghei NK65info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALECAM2013-742476.pdfECAM2013-742476.pdfapplication/pdf151520https://www.arca.fiocruz.br/bitstream/icict/59433/2/ECAM2013-742476.pdfcd2a94f758c6173771c27adc4639f9b4MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/59433/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/594332023-07-06 22:05:55.599oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-07-07T01:05:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies |
| title |
Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies |
| spellingShingle |
Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies Adebayo, Joseph Oluwatope Cocos nucifera Antimalarial Activity Plasmodium falciparum W2 Plasmodium berghei NK65 |
| title_short |
Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies |
| title_full |
Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies |
| title_fullStr |
Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies |
| title_full_unstemmed |
Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies |
| title_sort |
Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies |
| author |
Adebayo, Joseph Oluwatope |
| author_facet |
Adebayo, Joseph Oluwatope Balogun, E. A. Malomo, S. O. Soladoye, A. O. Olatunji, L. A. Kolawole, O. M. Oguntoye, O. S. Babatunde, A. S. Akinola, O. B. Aguiar, Anna Caroline Campos Andrade, Isabel Mayer de Souza, Nicolli Bellotti de Krettli, Antoniana Ursine |
| author_role |
author |
| author2 |
Balogun, E. A. Malomo, S. O. Soladoye, A. O. Olatunji, L. A. Kolawole, O. M. Oguntoye, O. S. Babatunde, A. S. Akinola, O. B. Aguiar, Anna Caroline Campos Andrade, Isabel Mayer de Souza, Nicolli Bellotti de Krettli, Antoniana Ursine |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Adebayo, Joseph Oluwatope Balogun, E. A. Malomo, S. O. Soladoye, A. O. Olatunji, L. A. Kolawole, O. M. Oguntoye, O. S. Babatunde, A. S. Akinola, O. B. Aguiar, Anna Caroline Campos Andrade, Isabel Mayer de Souza, Nicolli Bellotti de Krettli, Antoniana Ursine |
| dc.subject.en.none.fl_str_mv |
Cocos nucifera Antimalarial Activity Plasmodium falciparum W2 Plasmodium berghei NK65 |
| topic |
Cocos nucifera Antimalarial Activity Plasmodium falciparum W2 Plasmodium berghei NK65 |
| description |
Department of Biochemistry. University of Ilorin. Ilorin, Nigeria. |
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2013 |
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2013 |
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2023-07-06T13:05:07Z |
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2023-07-06T13:05:07Z |
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ADEBAYO, Joseph Oluwatope et al. Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies. Evidence-Based Complementary and Alternative Medicine, v. 2013, p. 1-9, Article ID 742476, 2013. |
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10.1155/2013/742476 |
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ADEBAYO, Joseph Oluwatope et al. Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies. Evidence-Based Complementary and Alternative Medicine, v. 2013, p. 1-9, Article ID 742476, 2013. 1741-427X 10.1155/2013/742476 |
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