Cell proliferation and interferon-gamma response to recombinant MBP-3, NarL, MT-10.3, and 16 kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/39717 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ, Brasil. |
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Tavares, Ricardo Candido OliveiraSalgado, JorgeMoreira, Valéria BarbosaFerreira, Mônica Antonia S.Mello, Fernanda Carvalho QueozLeung, Janaína A. W.Singh, MahavirFonseca, Leila de SouzaSaad, Maria Helena Feres2020-02-04T15:21:58Z2020-02-04T15:21:58Z2006TAVARES, Ricardo Candido Oliveira et al. Cell proliferation and interferon-g response to recombinant MBP-3, NarL, MT-10.3, and 16kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 8, p. 857-861, Dec. 2006.0074-0206https://www.arca.fiocruz.br/handle/icict/3971710.1590/s0074-027620060008000061678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzTuberculoseResposta imuneInterferon-yTuberculosis16 kDaMT10.3Interferon-γimmune responseCell proliferation and interferon-gamma response to recombinant MBP-3, NarL, MT-10.3, and 16 kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ, Brasil.Hospital Municipal Souza Aguiar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto Microbiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto Microbiologia. Rio de Janeiro, RJ, Brasil.Lionex Immuno Diagnostic and Therapeutic. Braunchweig, Germany.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto Microbiologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ, Brasil.Human pulmonary tuberculosis (TB) is a worldwide public health problem. In resistant individuals, control of the infection mainly requires development of a Th1 cell immune response with production of cytokines, of which interferon-gamma (IFN-gamma)plays an important role. Several antigens from Mycobacterium tuberculosis complex has been described for use in vaccine development or for diagnostic purposes, however little evaluation has been done in endemic area for TB. The proliferative and IFN-gamma human T cell immune responses, to four recombinant proteins (MBP-3, NarL, MT-10.3, 16 kDa) and PPD, of 38 Brazilian TB patients (6 untreated and 32 treated) and 67 controls (38 positive and 29 negative tuberculin skin test - TST) were compared. The highest reactivity mean rate was obtained with PPD followed by 16 kDa in TB patients. While most of the patients (87%) and controls (> 64%) respond to the PPD, 16 kDa was more specifically recognized (> 21%) although less sensitive (54%). When TB patients were divided according to treatment status, opposite to PPD, higher average level of IFN-gamma was induced by 16 kDa in untreated (505 pg/ml) compared to treated TB patients and TST+ (269.8 pg/ml x 221.6 pg/ml, respectively), although the difference was not significant. These data show that in contrast with the other recombinant proteins, the stimulatory potency of 16 kDa to induce proliferative and INF-gamma response was more effective and is more recognized by active TB untreated patients, eliciting in control individuals a more selective immune response than PPD.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/39717/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRicardo_Tavares_etal_IOC_2006.pdfRicardo_Tavares_etal_IOC_2006.pdfapplication/pdf157400https://www.arca.fiocruz.br/bitstream/icict/39717/2/Ricardo_Tavares_etal_IOC_2006.pdfc0defb10d27cb485d5d571c52751b6d9MD52TEXTRicardo_Tavares_etal_IOC_2006.pdf.txtRicardo_Tavares_etal_IOC_2006.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Cell proliferation and interferon-gamma response to recombinant MBP-3, NarL, MT-10.3, and 16 kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients |
| title |
Cell proliferation and interferon-gamma response to recombinant MBP-3, NarL, MT-10.3, and 16 kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients |
| spellingShingle |
Cell proliferation and interferon-gamma response to recombinant MBP-3, NarL, MT-10.3, and 16 kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients Tavares, Ricardo Candido Oliveira Tuberculose Resposta imune Interferon-y Tuberculosis 16 kDa MT10.3 Interferon-γ immune response |
| title_short |
Cell proliferation and interferon-gamma response to recombinant MBP-3, NarL, MT-10.3, and 16 kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients |
| title_full |
Cell proliferation and interferon-gamma response to recombinant MBP-3, NarL, MT-10.3, and 16 kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients |
| title_fullStr |
Cell proliferation and interferon-gamma response to recombinant MBP-3, NarL, MT-10.3, and 16 kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients |
| title_full_unstemmed |
Cell proliferation and interferon-gamma response to recombinant MBP-3, NarL, MT-10.3, and 16 kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients |
| title_sort |
Cell proliferation and interferon-gamma response to recombinant MBP-3, NarL, MT-10.3, and 16 kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients |
| author |
Tavares, Ricardo Candido Oliveira |
| author_facet |
Tavares, Ricardo Candido Oliveira Salgado, Jorge Moreira, Valéria Barbosa Ferreira, Mônica Antonia S. Mello, Fernanda Carvalho Queoz Leung, Janaína A. W. Singh, Mahavir Fonseca, Leila de Souza Saad, Maria Helena Feres |
| author_role |
author |
| author2 |
Salgado, Jorge Moreira, Valéria Barbosa Ferreira, Mônica Antonia S. Mello, Fernanda Carvalho Queoz Leung, Janaína A. W. Singh, Mahavir Fonseca, Leila de Souza Saad, Maria Helena Feres |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Tavares, Ricardo Candido Oliveira Salgado, Jorge Moreira, Valéria Barbosa Ferreira, Mônica Antonia S. Mello, Fernanda Carvalho Queoz Leung, Janaína A. W. Singh, Mahavir Fonseca, Leila de Souza Saad, Maria Helena Feres |
| dc.subject.other.pt_BR.fl_str_mv |
Tuberculose Resposta imune Interferon-y |
| topic |
Tuberculose Resposta imune Interferon-y Tuberculosis 16 kDa MT10.3 Interferon-γ immune response |
| dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis 16 kDa MT10.3 Interferon-γ immune response |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micobacterioses. Rio de Janeiro, RJ, Brasil. |
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2006 |
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2006 |
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2020-02-04T15:21:58Z |
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2020-02-04T15:21:58Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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TAVARES, Ricardo Candido Oliveira et al. Cell proliferation and interferon-g response to recombinant MBP-3, NarL, MT-10.3, and 16kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 8, p. 857-861, Dec. 2006. |
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https://www.arca.fiocruz.br/handle/icict/39717 |
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0074-0206 |
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10.1590/s0074-02762006000800006 |
| dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
| identifier_str_mv |
TAVARES, Ricardo Candido Oliveira et al. Cell proliferation and interferon-g response to recombinant MBP-3, NarL, MT-10.3, and 16kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 8, p. 857-861, Dec. 2006. 0074-0206 10.1590/s0074-02762006000800006 1678-8060 |
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