Innate immunity and regulatory T-cells in human Chagas disease: what must be understood

Detalhes bibliográficos
Autor(a) principal: Avelar, Renato Sathler
Data de Publicação: 2009
Outros Autores: Avelar, Danielle Marquete Vitelli, Carvalho, Andréa Teixeira de, Martins Filho, Olindo Assis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58805
https://doi.org/10.1590/S0074-02762009000900031
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil
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spelling Avelar, Renato SathlerAvelar, Danielle Marquete VitelliCarvalho, Andréa Teixeira deMartins Filho, Olindo Assis2023-05-29T18:14:26Z2023-05-29T18:14:26Z2009AVELAR, Renato Sathler et al. Innate immunity and regulatory T-cells in human Chagas disease: what must be understood? Mem. Inst. Oswaldo Cruz, v. 104, suppl 1, p. 246-251, 2009. doi.org/10.1590/S0074-027620090009000310074-0276https://www.arca.fiocruz.br/handle/icict/58805https://doi.org/10.1590/S0074-02762009000900031engMinistério da SaúdeInnate immunity and regulatory T-cells in human Chagas disease: what must be understoodinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilThere is a general consensus that during chronic Trypanosoma cruzi infection, the host immune system induces complex processes to ensure the control of parasite growth while preserving the potential to mount and maintain a life-long controlled humoral and cellular immune response against the invading pathogen. This review summarises evidence in an attempt to elucidate "what must be understood" to further clarify the role of innate immunity in the development/maintenance of clinical Chagas disease and the impact of etiological treatment on host immunity, highlighting the contributions of the innate immunity and regulatory T (Treg) cells. Recently, increasing focus on innate immunity suggest that chronic T. cruzi infection may cause morbidity when innate effector functions, or the down-regulation of adaptive regulatory mechanisms are lacking. In this context, stable asymptomatic host-parasite interactions seem to be influenced by the effector/regulatory balance with the participation of macrophages, natural killer (NK) and CD8(+) T cells in parallel with the establishment of regulatory mechanisms mediated by NKT and Treg cells. Moreover, a balanced innate immune activation state, apart from Treg cells, may play a role in controlling the adverse events triggered by the massive antigen release induced by trypanosomicidal agents during Chagas disease etiological treatmenthuman Chagas diseaseinnate immunityregulatory T-cellsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALdoi_10.1016_j.trstmh.2009.04.007.pdfdoi_10.1016_j.trstmh.2009.04.007.pdfapplication/pdf257700https://www.arca.fiocruz.br/bitstream/icict/58805/2/doi_10.1016_j.trstmh.2009.04.007.pdfe49fec642ab27e2ece6e344d9f0f42f7MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/58805/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/588052023-05-29 15:14:27.896oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-29T18:14:27Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Innate immunity and regulatory T-cells in human Chagas disease: what must be understood
title Innate immunity and regulatory T-cells in human Chagas disease: what must be understood
spellingShingle Innate immunity and regulatory T-cells in human Chagas disease: what must be understood
Avelar, Renato Sathler
human Chagas disease
innate immunity
regulatory T-cells
title_short Innate immunity and regulatory T-cells in human Chagas disease: what must be understood
title_full Innate immunity and regulatory T-cells in human Chagas disease: what must be understood
title_fullStr Innate immunity and regulatory T-cells in human Chagas disease: what must be understood
title_full_unstemmed Innate immunity and regulatory T-cells in human Chagas disease: what must be understood
title_sort Innate immunity and regulatory T-cells in human Chagas disease: what must be understood
author Avelar, Renato Sathler
author_facet Avelar, Renato Sathler
Avelar, Danielle Marquete Vitelli
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
author_role author
author2 Avelar, Danielle Marquete Vitelli
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
author2_role author
author
author
dc.contributor.author.fl_str_mv Avelar, Renato Sathler
Avelar, Danielle Marquete Vitelli
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
dc.subject.en.en_US.fl_str_mv human Chagas disease
innate immunity
regulatory T-cells
topic human Chagas disease
innate immunity
regulatory T-cells
description Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2023-05-29T18:14:26Z
dc.date.available.fl_str_mv 2023-05-29T18:14:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AVELAR, Renato Sathler et al. Innate immunity and regulatory T-cells in human Chagas disease: what must be understood? Mem. Inst. Oswaldo Cruz, v. 104, suppl 1, p. 246-251, 2009. doi.org/10.1590/S0074-02762009000900031
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58805
dc.identifier.issn.en_US.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1590/S0074-02762009000900031
identifier_str_mv AVELAR, Renato Sathler et al. Innate immunity and regulatory T-cells in human Chagas disease: what must be understood? Mem. Inst. Oswaldo Cruz, v. 104, suppl 1, p. 246-251, 2009. doi.org/10.1590/S0074-02762009000900031
0074-0276
url https://www.arca.fiocruz.br/handle/icict/58805
https://doi.org/10.1590/S0074-02762009000900031
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Ministério da Saúde
publisher.none.fl_str_mv Ministério da Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58805/2/doi_10.1016_j.trstmh.2009.04.007.pdf
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