A short history of innate immunity

Detalhes bibliográficos
Autor(a) principal: Martins, Yuri Chaves
Data de Publicação: 2023
Outros Autores: Ribeiro-Gomes, Flávia Lima, Daniel-Ribeiro, Cláudio Tadeu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/0074-02760230023
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57808
Resumo: Financial support: FLR-G and CTD-R are supported by the CNPq, through a Productivity Research Fellowship; CTD-R is a Cientista do Nosso Estado by the FAPERJ. The Laboratório de Pesquisa em Malária (IOC), Fiocruz, is an Associated Laboratory of the INCT em Neuroimunomodulação supported by the CNPq (Project INCT-NIM 465489/2014-1), and of the Rede de Neuroinflamação do Rio de Janeiro financed by FAPERJ (Project Redes/FAPERJ 26010.002418/2019).
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spelling Martins, Yuri ChavesRibeiro-Gomes, Flávia LimaDaniel-Ribeiro, Cláudio Tadeu2023-04-15T18:30:43Z2023-04-15T18:30:43Z2023MARTINS, Yuri Chaves; RIBEIRO-GOMES, Flávia Lima; DANIEL-RIBEIRO, Cláudio Tadeu. A short history of innate immunity. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 118, e230023, p. 1-11, 2023.0074-0206https://www.arca.fiocruz.br/handle/icict/5780810.1590/0074-02760230023Financial support: FLR-G and CTD-R are supported by the CNPq, through a Productivity Research Fellowship; CTD-R is a Cientista do Nosso Estado by the FAPERJ. The Laboratório de Pesquisa em Malária (IOC), Fiocruz, is an Associated Laboratory of the INCT em Neuroimunomodulação supported by the CNPq (Project INCT-NIM 465489/2014-1), and of the Rede de Neuroinflamação do Rio de Janeiro financed by FAPERJ (Project Redes/FAPERJ 26010.002418/2019).Saint Louis University School of Medicine, Department of Anesthesiology, Saint Louis, MO, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Innate immunity refers to the mechanisms responsible for the first line of defense against pathogens, cancer cells and toxins. The innate immune system is also responsible for the initial activation of the body’s specific immune response (adaptive immunity). Innate immunity was studied and further developed in parallel with adaptive immunity beginning in the first half of the 19th century and has been gaining increasing importance to our understanding of health and disease. In the present overview, we describe the main findings and ideas that contributed to the development of innate immunity as a continually expanding branch of modern immunology. We start with the toxicological studies by Von Haller and Magendie, in the late 18th and early 19th centuries, and continue with the discoveries in invertebrate immunity that supported the discovery and characterization of lipopolysaccharide (LPS) and pattern recognition receptors that led to the development of the pattern recognition and danger theory.engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Resposta imuneInflamaçãoImunidade inataHistóriaImunologia modernaImmune responseInflammationInnate immunityHistoryModern immunologyA short history of innate immunityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALYuriMartins_ClaudioTRibeiro_etal_IOC_2023.pdfYuriMartins_ClaudioTRibeiro_etal_IOC_2023.pdfapplication/pdf1579559https://www.arca.fiocruz.br/bitstream/icict/57808/2/YuriMartins_ClaudioTRibeiro_etal_IOC_2023.pdf98fcb2f3a16d0e9bdeba2f6c1a5b545fMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57808/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/578082023-09-04 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dc.title.en_US.fl_str_mv A short history of innate immunity
title A short history of innate immunity
spellingShingle A short history of innate immunity
Martins, Yuri Chaves
Resposta imune
Inflamação
Imunidade inata
História
Imunologia moderna
Immune response
Inflammation
Innate immunity
History
Modern immunology
title_short A short history of innate immunity
title_full A short history of innate immunity
title_fullStr A short history of innate immunity
title_full_unstemmed A short history of innate immunity
title_sort A short history of innate immunity
author Martins, Yuri Chaves
author_facet Martins, Yuri Chaves
Ribeiro-Gomes, Flávia Lima
Daniel-Ribeiro, Cláudio Tadeu
author_role author
author2 Ribeiro-Gomes, Flávia Lima
Daniel-Ribeiro, Cláudio Tadeu
author2_role author
author
dc.contributor.author.fl_str_mv Martins, Yuri Chaves
Ribeiro-Gomes, Flávia Lima
Daniel-Ribeiro, Cláudio Tadeu
dc.subject.other.en_US.fl_str_mv Resposta imune
Inflamação
Imunidade inata
História
Imunologia moderna
topic Resposta imune
Inflamação
Imunidade inata
História
Imunologia moderna
Immune response
Inflammation
Innate immunity
History
Modern immunology
dc.subject.en.en_US.fl_str_mv Immune response
Inflammation
Innate immunity
History
Modern immunology
description Financial support: FLR-G and CTD-R are supported by the CNPq, through a Productivity Research Fellowship; CTD-R is a Cientista do Nosso Estado by the FAPERJ. The Laboratório de Pesquisa em Malária (IOC), Fiocruz, is an Associated Laboratory of the INCT em Neuroimunomodulação supported by the CNPq (Project INCT-NIM 465489/2014-1), and of the Rede de Neuroinflamação do Rio de Janeiro financed by FAPERJ (Project Redes/FAPERJ 26010.002418/2019).
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-04-15T18:30:43Z
dc.date.available.fl_str_mv 2023-04-15T18:30:43Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MARTINS, Yuri Chaves; RIBEIRO-GOMES, Flávia Lima; DANIEL-RIBEIRO, Cláudio Tadeu. A short history of innate immunity. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 118, e230023, p. 1-11, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57808
dc.identifier.issn.en_US.fl_str_mv 0074-0206
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760230023
identifier_str_mv MARTINS, Yuri Chaves; RIBEIRO-GOMES, Flávia Lima; DANIEL-RIBEIRO, Cláudio Tadeu. A short history of innate immunity. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 118, e230023, p. 1-11, 2023.
0074-0206
10.1590/0074-02760230023
url https://www.arca.fiocruz.br/handle/icict/57808
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57808/2/YuriMartins_ClaudioTRibeiro_etal_IOC_2023.pdf
https://www.arca.fiocruz.br/bitstream/icict/57808/1/license.txt
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