Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon

Detalhes bibliográficos
Autor(a) principal: Petrilli, Jéssica D.
Data de Publicação: 2020
Outros Autores: Müller, Igor, Araújo, Luana E, Cardoso, Thiago M., Carvalho, Lucas Pedreira, Barros, Bruna C., Teixeira, Maurício, Arruda, Sérgio Marcos, Riley, Lee W., Queiroz, Adriano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43365
Resumo: NIH FIC R25TW009338 Global Health Equity Scholarsby and in part by the Research Program for SUS-PPSUS/BA [SUS 0027/2018]. JP was a recipient of a Ph.D. fellowship from Oswaldo Cruz Foundation/FIOCRUZ and MT was a recipient of a CAPES Ph.D. scholarship. AQ was a recipient of the GHES fellowship.
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spelling Petrilli, Jéssica D.Müller, IgorAraújo, Luana ECardoso, Thiago M.Carvalho, Lucas PedreiraBarros, Bruna C.Teixeira, MaurícioArruda, Sérgio MarcosRiley, Lee W.Queiroz, Adriano2020-09-15T11:40:59Z2020-09-15T11:40:59Z2020PETRILLI, Jéssica D. et al. Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon. Frontiers in Immunology, p. 1-10, Aug. 2020.1664-3224https://www.arca.fiocruz.br/handle/icict/4336510.3389/fimmu.2020.01848NIH FIC R25TW009338 Global Health Equity Scholarsby and in part by the Research Program for SUS-PPSUS/BA [SUS 0027/2018]. JP was a recipient of a Ph.D. fellowship from Oswaldo Cruz Foundation/FIOCRUZ and MT was a recipient of a CAPES Ph.D. scholarship. AQ was a recipient of the GHES fellowship.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratorio Avançado de Saúde Pública. Salvador, BA, Brasil.University of California. School of Public Health. Division of Infectious Diseases and Vaccinology. Berkeley, CA, United States.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.The cell wall of wild-type (WT) Mycobacterium tuberculosis (Mtb), an etiologic agent of tuberculosis (TB) and a Mtb strain disrupted in a 13-gene operon mce1 (1mce1) varies by more than 400 lipid species. Here, we examined Mtb lipid-induced response in murine macrophage, as well as in human T-cell subpopulations in order to gain an insight into how changes in cell wall lipid composition may modulate host immune response. Relative to WT Mtb cell wall lipids, the non-polar lipid extracts from 1mce1 enhanced the mRNA expression of lipid-sense nuclear receptors TR4 and PPAR-g and dampened the macrophage expression of genes encoding TNF-a, IL-6, and IL-1b. Relative to untreated control, WT lipid-pre-stimulatedmacrophages fromhealthy individuals induced a higher level of CD4−CD8− double negative T-cells (DN T-cells) producing TNF-a. Conversely, compared to WT, stimulation with 1mce1 lipids induced higher mean fluorescence intensity (MFI) in IL-10-producing DN T cells. Mononuclear cells from TB patients stimulated with WT Mtb lipids induced an increased production of TNF-a by CD8+ lymphocytes. Taken together, these observations suggest that changes in mce1 operon expression during a course of infection may serve as a strategy by Mtb to evade the host pro-inflammatory responses.engFrontiers MediaMycobacterium tuberculosisLipídiosMicobacteriasLipídios da membrana celularinflamaçãoMycobacterium tuberculosisLipid-induced responsesMce1 operonMycobacterial cell wall lipidInflammationDifferential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43365/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPetrilli, Jessica D. Differential....pdfPetrilli, Jessica D. Differential....pdfapplication/pdf1929927https://www.arca.fiocruz.br/bitstream/icict/43365/2/Petrilli%2c%20Jessica%20D.%20Differential....pdf4b74b6154ec8c85b18c26af1e96891b7MD52TEXTPetrilli, Jessica D. Differential....pdf.txtPetrilli, Jessica D. 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dc.title.pt_BR.fl_str_mv Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon
title Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon
spellingShingle Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon
Petrilli, Jéssica D.
Mycobacterium tuberculosis
Lipídios
Micobacterias
Lipídios da membrana celular
inflamação
Mycobacterium tuberculosis
Lipid-induced responses
Mce1 operon
Mycobacterial cell wall lipid
Inflammation
title_short Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon
title_full Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon
title_fullStr Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon
title_full_unstemmed Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon
title_sort Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon
author Petrilli, Jéssica D.
author_facet Petrilli, Jéssica D.
Müller, Igor
Araújo, Luana E
Cardoso, Thiago M.
Carvalho, Lucas Pedreira
Barros, Bruna C.
Teixeira, Maurício
Arruda, Sérgio Marcos
Riley, Lee W.
Queiroz, Adriano
author_role author
author2 Müller, Igor
Araújo, Luana E
Cardoso, Thiago M.
Carvalho, Lucas Pedreira
Barros, Bruna C.
Teixeira, Maurício
Arruda, Sérgio Marcos
Riley, Lee W.
Queiroz, Adriano
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Petrilli, Jéssica D.
Müller, Igor
Araújo, Luana E
Cardoso, Thiago M.
Carvalho, Lucas Pedreira
Barros, Bruna C.
Teixeira, Maurício
Arruda, Sérgio Marcos
Riley, Lee W.
Queiroz, Adriano
dc.subject.other.pt_BR.fl_str_mv Mycobacterium tuberculosis
Lipídios
Micobacterias
Lipídios da membrana celular
inflamação
topic Mycobacterium tuberculosis
Lipídios
Micobacterias
Lipídios da membrana celular
inflamação
Mycobacterium tuberculosis
Lipid-induced responses
Mce1 operon
Mycobacterial cell wall lipid
Inflammation
dc.subject.en.pt_BR.fl_str_mv Mycobacterium tuberculosis
Lipid-induced responses
Mce1 operon
Mycobacterial cell wall lipid
Inflammation
description NIH FIC R25TW009338 Global Health Equity Scholarsby and in part by the Research Program for SUS-PPSUS/BA [SUS 0027/2018]. JP was a recipient of a Ph.D. fellowship from Oswaldo Cruz Foundation/FIOCRUZ and MT was a recipient of a CAPES Ph.D. scholarship. AQ was a recipient of the GHES fellowship.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-09-15T11:40:59Z
dc.date.available.fl_str_mv 2020-09-15T11:40:59Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PETRILLI, Jéssica D. et al. Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon. Frontiers in Immunology, p. 1-10, Aug. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43365
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.pt_BR.fl_str_mv 10.3389/fimmu.2020.01848
identifier_str_mv PETRILLI, Jéssica D. et al. Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon. Frontiers in Immunology, p. 1-10, Aug. 2020.
1664-3224
10.3389/fimmu.2020.01848
url https://www.arca.fiocruz.br/handle/icict/43365
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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