Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10186 |
Resumo: | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil. |
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Cuba, Marília Beatriz deMachado, Marcus Paulo RibeiroFarnesi, Thais SoaresAlves, Angelica CristinaMartins, Livia AlvesOliveira, Lucas Felipe deCapitelli, Caroline SantosLeite, Camila FerreiraSilva, Marcos ViniciusMachado, Juliana ReisKappel, Henrique BorgesCampos, Helioswilton Sales dePaiva, LucianoGomes, Natália Lins da SilvaFaleiros, Ana Carolina GuimarãesBritto, Constança Felicia de Paoli de CarvalhoSavino, WilsonMoreira, Otacílio CruzRodrigues Jr., VirmondesMontano, NicolaSilva, Eliane LagesRamirez, Luis EduardoSilva, Valdo José Dias da2015-05-04T16:34:37Z2015-05-04T16:34:37Z2014CUBA, Marília Beatriz de; et al. Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice. Mediators of Inflammation, v.2014, 13p., 2014.https://www.arca.fiocruz.br/handle/icict/1018610.1155/2014/475946engHindawi Publishing CorporationDoença de ChagasTrypanosoma cruziCamundongosBrometo de PiridostigminaChagas diseaseTrypanosoma cruziPyridostigmine BromideCholinergicTrypanosoma cruziRatonesCamundongosColinérgicosBrometo de PiridostigminaEffects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.University of Milan. L Sacco Hospital. Department of Clinical Sciences, Internal Medicine II. Milan, Italy.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.The aim of the present study was to assess the effects of an anticholinesterase agent, pyridostigmine bromide (Pyrido), on experimental chronic Chagas heart disease in mice. To this end, male C57BL/6J mice noninfected (control:Con) or chronically infected (5 months) with Trypanosoma cruzi (chagasic:Chg) were treated or not (NT) with Pyrido for one month. At the end of this period, electrocardiogram (ECG); cardiac autonomic function; heart histopathology; serum cytokines; and the presence of blood and tissue parasites by means of immunohistochemistry and PCR were assessed. In NT-Chg mice, significant changes in the electrocardiographic, autonomic, and cardiac histopathological profiles were observed confirming a chronic inflammatory response. Treatment with Pyrido in Chagasic mice caused a significant reduction of myocardial inflammatory infiltration, fibrosis, and hypertrophy, which was accompanied by a decrease in serum levels of IFN with no change in IL-10 levels, suggesting a shift of immune response toward an anti-inflammatory profile. Lower nondifferent numbers of parasite DNA copies were observed in both treated and nontreated chagasic mice. In conclusion, our findings confirmthe marked neuroimmunomodulatory role played by the parasympathetic autonomic nervous systemin the evolution of the inflammatory-immune response to T. cruzi during experimental chronic Chagas heart disease in mice.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10186/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALconstança_brittoetal_IOC_2014.pdfapplication/pdf3857100https://www.arca.fiocruz.br/bitstream/icict/10186/2/constan%c3%a7a_brittoetal_IOC_2014.pdf42bae205f256c445117f5bd53964bde3MD52TEXTconstança_brittoetal_IOC_2014.pdf.txtconstança_brittoetal_IOC_2014.pdf.txtExtracted texttext/plain58927https://www.arca.fiocruz.br/bitstream/icict/10186/3/constan%c3%a7a_brittoetal_IOC_2014.pdf.txt6948e5abaadc8cfa6698aff4d1d2168aMD53icict/101862022-06-24 13:02:53.82oai:www.arca.fiocruz.br:icict/10186TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:02:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice |
| title |
Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice |
| spellingShingle |
Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice Cuba, Marília Beatriz de Doença de Chagas Trypanosoma cruzi Camundongos Brometo de Piridostigmina Chagas disease Trypanosoma cruzi Pyridostigmine Bromide Cholinergic Trypanosoma cruzi Ratones Camundongos Colinérgicos Brometo de Piridostigmina |
| title_short |
Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice |
| title_full |
Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice |
| title_fullStr |
Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice |
| title_full_unstemmed |
Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice |
| title_sort |
Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice |
| author |
Cuba, Marília Beatriz de |
| author_facet |
Cuba, Marília Beatriz de Machado, Marcus Paulo Ribeiro Farnesi, Thais Soares Alves, Angelica Cristina Martins, Livia Alves Oliveira, Lucas Felipe de Capitelli, Caroline Santos Leite, Camila Ferreira Silva, Marcos Vinicius Machado, Juliana Reis Kappel, Henrique Borges Campos, Helioswilton Sales de Paiva, Luciano Gomes, Natália Lins da Silva Faleiros, Ana Carolina Guimarães Britto, Constança Felicia de Paoli de Carvalho Savino, Wilson Moreira, Otacílio Cruz Rodrigues Jr., Virmondes Montano, Nicola Silva, Eliane Lages Ramirez, Luis Eduardo Silva, Valdo José Dias da |
| author_role |
author |
| author2 |
Machado, Marcus Paulo Ribeiro Farnesi, Thais Soares Alves, Angelica Cristina Martins, Livia Alves Oliveira, Lucas Felipe de Capitelli, Caroline Santos Leite, Camila Ferreira Silva, Marcos Vinicius Machado, Juliana Reis Kappel, Henrique Borges Campos, Helioswilton Sales de Paiva, Luciano Gomes, Natália Lins da Silva Faleiros, Ana Carolina Guimarães Britto, Constança Felicia de Paoli de Carvalho Savino, Wilson Moreira, Otacílio Cruz Rodrigues Jr., Virmondes Montano, Nicola Silva, Eliane Lages Ramirez, Luis Eduardo Silva, Valdo José Dias da |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cuba, Marília Beatriz de Machado, Marcus Paulo Ribeiro Farnesi, Thais Soares Alves, Angelica Cristina Martins, Livia Alves Oliveira, Lucas Felipe de Capitelli, Caroline Santos Leite, Camila Ferreira Silva, Marcos Vinicius Machado, Juliana Reis Kappel, Henrique Borges Campos, Helioswilton Sales de Paiva, Luciano Gomes, Natália Lins da Silva Faleiros, Ana Carolina Guimarães Britto, Constança Felicia de Paoli de Carvalho Savino, Wilson Moreira, Otacílio Cruz Rodrigues Jr., Virmondes Montano, Nicola Silva, Eliane Lages Ramirez, Luis Eduardo Silva, Valdo José Dias da |
| dc.subject.other.pt_BR.fl_str_mv |
Doença de Chagas Trypanosoma cruzi Camundongos Brometo de Piridostigmina |
| topic |
Doença de Chagas Trypanosoma cruzi Camundongos Brometo de Piridostigmina Chagas disease Trypanosoma cruzi Pyridostigmine Bromide Cholinergic Trypanosoma cruzi Ratones Camundongos Colinérgicos Brometo de Piridostigmina |
| dc.subject.en.pt_BR.fl_str_mv |
Chagas disease Trypanosoma cruzi Pyridostigmine Bromide Cholinergic |
| dc.subject.es.pt_BR.fl_str_mv |
Trypanosoma cruzi Ratones |
| dc.subject.decs.pt_BR.fl_str_mv |
Camundongos Colinérgicos Brometo de Piridostigmina |
| description |
Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil. |
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2014 |
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2014 |
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2015-05-04T16:34:37Z |
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2015-05-04T16:34:37Z |
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info:eu-repo/semantics/article |
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article |
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CUBA, Marília Beatriz de; et al. Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice. Mediators of Inflammation, v.2014, 13p., 2014. |
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https://www.arca.fiocruz.br/handle/icict/10186 |
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10.1155/2014/475946 |
| identifier_str_mv |
CUBA, Marília Beatriz de; et al. Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice. Mediators of Inflammation, v.2014, 13p., 2014. 10.1155/2014/475946 |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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