Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study

Fernandes, Geraldo Magela; Sasaki, Lizandra Moura Paravidine; Jardim-Santos, Gabriela Profírio; Schulte, Heidi Luise; Motta, Felipe; Silva, Ângelo Pereira da; Carvalho, Aleida Oliveira de; Pereira, Yacara Ribeiro; Alves, Caroline de Oliveira; Araújo Júnior, David Alves de; Mendonça-Silva, Dayde Lane; Costa, Karina Nascimento; Castro, Maria Eduarda Canellas de; Lauand, Lucas; Nery, Rodrigo de Resende; Tristão, Rosana; Kurizky, Patricia Shu; Nóbrega, Otávio de Toledo; Espindola, Laila Salmen; Castro, Luiz Cláudio Gonçalves de; Alpoim, Patrícia Nessralla; Godoi, Lara Carvalho; Dusse, Luci Maria Sant Ana; Reis, Jordana Grazziela Alves Coelho Dos; Amaral, Laurence Rodrigues do; Gomes, Matheus de Souza; Bertarini, Pedro Luiz Lima; Sousa, Joaquim Pedro Brito de; Rocha, Ismael Artur da Costa; Azevedo, Ana Carolina Campi; Pascoal, Vanessa Peruhype Magalhães; Carvalho, Andrea Teixeira de; Zaconeta, Alberto Moreno; Soares, Alexandre Anderson de Sousa Munhoz; Valim, Valéria; Gomes, Ciro Martins; Albuquerque, Cleandro Pires de; Martins Filho, Olindo Assis; Mota, Licia Maria Henrique da

Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study

Detalhes bibliográficos
Autor(a) principal:	Fernandes, Geraldo Magela
Data de Publicação:	2023
Outros Autores:	Sasaki, Lizandra Moura Paravidine, Jardim-Santos, Gabriela Profírio, Schulte, Heidi Luise, Motta, Felipe, Silva, Ângelo Pereira da, Carvalho, Aleida Oliveira de, Pereira, Yacara Ribeiro, Alves, Caroline de Oliveira, Araújo Júnior, David Alves de, Mendonça-Silva, Dayde Lane, Costa, Karina Nascimento, Castro, Maria Eduarda Canellas de, Lauand, Lucas, Nery, Rodrigo de Resende, Tristão, Rosana, Kurizky, Patricia Shu, Nóbrega, Otávio de Toledo, Espindola, Laila Salmen, Castro, Luiz Cláudio Gonçalves de, Alpoim, Patrícia Nessralla, Godoi, Lara Carvalho, Dusse, Luci Maria Sant Ana, Reis, Jordana Grazziela Alves Coelho Dos, Amaral, Laurence Rodrigues do, Gomes, Matheus de Souza, Bertarini, Pedro Luiz Lima, Sousa, Joaquim Pedro Brito de, Rocha, Ismael Artur da Costa, Azevedo, Ana Carolina Campi, Pascoal, Vanessa Peruhype Magalhães, Carvalho, Andrea Teixeira de, Zaconeta, Alberto Moreno, Soares, Alexandre Anderson de Sousa Munhoz, Valim, Valéria, Gomes, Ciro Martins, Albuquerque, Cleandro Pires de, Martins Filho, Olindo Assis, Mota, Licia Maria Henrique da
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/58318
Resumo:	Universidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil

Metadados do item

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oai_identifier_str	oai:www.arca.fiocruz.br:icict/58318
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Fernandes, Geraldo MagelaSasaki, Lizandra Moura ParavidineJardim-Santos, Gabriela ProfírioSchulte, Heidi LuiseMotta, FelipeSilva, Ângelo Pereira daCarvalho, Aleida Oliveira dePereira, Yacara RibeiroAlves, Caroline de OliveiraAraújo Júnior, David Alves deMendonça-Silva, Dayde LaneCosta, Karina NascimentoCastro, Maria Eduarda Canellas deLauand, LucasNery, Rodrigo de ResendeTristão, RosanaKurizky, Patricia ShuNóbrega, Otávio de ToledoEspindola, Laila SalmenCastro, Luiz Cláudio Gonçalves deAlpoim, Patrícia NessrallaGodoi, Lara CarvalhoDusse, Luci Maria Sant AnaReis, Jordana Grazziela Alves Coelho DosAmaral, Laurence Rodrigues doGomes, Matheus de SouzaBertarini, Pedro Luiz LimaSousa, Joaquim Pedro Brito deRocha, Ismael Artur da CostaAzevedo, Ana Carolina CampiPascoal, Vanessa Peruhype MagalhãesCarvalho, Andrea Teixeira deZaconeta, Alberto MorenoSoares, Alexandre Anderson de Sousa MunhozValim, ValériaGomes, Ciro MartinsAlbuquerque, Cleandro Pires deMartins Filho, Olindo AssisMota, Licia Maria Henrique da2023-05-11T14:18:13Z2023-05-11T14:18:13Z2023FERNANDES, Geraldo Magela et al. Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study. Frontiers in immunology, v. 14, 176898. doi: 10.3389/fimmu.2023.1176898.1664-3224https://www.arca.fiocruz.br/handle/icict/58318engFrontiers Research FoundationPanoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, BrazilUniversidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil/ Universidade de Brasília. Hospital Universitário de Brasília. Brasília, DF, Brazil.Universidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, BrazilUniversidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, BrazilUniversidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, BrazilUniversidade de Brasília. Hospital Universitário de Brasília. Brasília, DF, Brazil.Universidade de Brasília. Hospital Universitário de Brasília. Brasília, DF, Brazil.Universidade de Brasília. Hospital Universitário de Brasília. Brasília, DF, Brazil.Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil.Universidade de Brasília. Hospital Universitário de Brasília. Brasília, DF, Brazil.Universidade de Brasília. Hospital Universitário de Brasília. Brasília, DF, Brazil.Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil.Universidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil/ Universidade de Brasília. Hospital Universitário de Brasília. Brasília, DF, Brazil.Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil.Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil.Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil.Universidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil/ Universidade de Brasília. Hospital Universitário de Brasília. Brasília, DF, Brazil.Universidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil.Universidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil.Universidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil/ Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil.Universidade Federal de Uberlândia. Laboratório de Bioinformática e Análises Moleculares. Patos de Minas, MG, Brazil.Universidade Federal de Uberlândia. Laboratório de Bioinformática e Análises Moleculares. Patos de Minas, MG, Brazil.Universidade Federal de Uberlândia. Laboratório de Bioinformática e Análises Moleculares. Patos de Minas, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil.Universidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil/Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil.Universidade Federal do Espírito Santo. Hospital Universitário Cassiano Antônio Moraes. Vitória, ES, Brazil/Universidade Federal do Espírito Santo. Centro de Ciências Médicas. Programa de Pós-Graduação em Saúde Coletiva. Vitória, ES, Brazil.Universidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil/Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil/Universidade de Brasília. Programa de Pós-Graduação em Patologia Molecular. Brasília, DF, Brazil.Universidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil/Universidade de Brasília. Hospital Universitário de Brasília. Brasília, DF, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Universidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil/Universidade de Brasília. Hospital Universitário de Brasília. Brasília, DF, Brazil/ Universidade de Brasília. Programa de Pós-Graduação em Patologia Molecular. Brasília, DF, Brazil.Introduction: SARS-CoV-2 infection during pregnancy can induce changes in the maternal immune response, with effects on pregnancy outcome and offspring. This is a cross-sectional observational study designed to characterize the immunological status of pregnant women with convalescent COVID-19 at distinct pregnancy trimesters. The study focused on providing a clear snapshot of the interplay among serum soluble mediators. Methods: A sample of 141 pregnant women from all prenatal periods (1st, 2nd and 3rd trimesters) comprised patients with convalescent SARS-CoV-2 infection at 3-20 weeks after symptoms onset (COVID, n=89) and a control group of pre-pandemic non-infected pregnant women (HC, n=52). Chemokine, pro-inflammatory/regulatory cytokine and growth factor levels were quantified by a high-throughput microbeads array. Results: In the HC group, most serum soluble mediators progressively decreased towards the 2nd and 3rd trimesters of pregnancy, while higher chemokine, cytokine and growth factor levels were observed in the COVID patient group. Serum soluble mediator signatures and heatmap analysis pointed out that the major increase observed in the COVID group related to pro-inflammatory cytokines (IL-6, TNF-α, IL-12, IFN-γ and IL-17). A larger set of biomarkers displayed an increased COVID/HC ratio towards the 2nd (3x increase) and the 3rd (3x to 15x increase) trimesters. Integrative network analysis demonstrated that HC pregnancy evolves with decreasing connectivity between pairs of serum soluble mediators towards the 3rd trimester. Although the COVID group exhibited a similar profile, the number of connections was remarkably lower throughout the pregnancy. Meanwhile, IL-1Ra, IL-10 and GM-CSF presented a preserved number of correlations (≥5 strong correlations in HC and COVID), IL-17, FGF-basic and VEGF lost connectivity throughout the pregnancy. IL-6 and CXCL8 were included in a set of acquired attributes, named COVID-selective (≥5 strong correlations in COVID and <5 in HC) observed at the 3rd pregnancy trimester. Discussion and conclusion: From an overall perspective, a pronounced increase in serum levels of soluble mediators with decreased network interplay between them demonstrated an imbalanced immune response in convalescent COVID-19 infection during pregnancy that may contribute to the management of, or indeed recovery from, late complications in the post-symptomatic phase of the SARS-CoV-2 infection in pregnant women.COVID-19chemokinescytokinesgrowth factorspregnancyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58318/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPanoramic snapshot of serum soluble mediator.pdfPanoramic snapshot of serum soluble 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11:18:14.046oai:www.arca.fiocruz.br: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ório 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dc.title.en_US.fl_str_mv	Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study
title	Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study
spellingShingle	Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study Fernandes, Geraldo Magela COVID-19 chemokines cytokines growth factors pregnancy
title_short	Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study
title_full	Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study
title_fullStr	Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study
title_full_unstemmed	Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study
title_sort	Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study
author	Fernandes, Geraldo Magela
author_facet	Fernandes, Geraldo Magela Sasaki, Lizandra Moura Paravidine Jardim-Santos, Gabriela Profírio Schulte, Heidi Luise Motta, Felipe Silva, Ângelo Pereira da Carvalho, Aleida Oliveira de Pereira, Yacara Ribeiro Alves, Caroline de Oliveira Araújo Júnior, David Alves de Mendonça-Silva, Dayde Lane Costa, Karina Nascimento Castro, Maria Eduarda Canellas de Lauand, Lucas Nery, Rodrigo de Resende Tristão, Rosana Kurizky, Patricia Shu Nóbrega, Otávio de Toledo Espindola, Laila Salmen Castro, Luiz Cláudio Gonçalves de Alpoim, Patrícia Nessralla Godoi, Lara Carvalho Dusse, Luci Maria Sant Ana Reis, Jordana Grazziela Alves Coelho Dos Amaral, Laurence Rodrigues do Gomes, Matheus de Souza Bertarini, Pedro Luiz Lima Sousa, Joaquim Pedro Brito de Rocha, Ismael Artur da Costa Azevedo, Ana Carolina Campi Pascoal, Vanessa Peruhype Magalhães Carvalho, Andrea Teixeira de Zaconeta, Alberto Moreno Soares, Alexandre Anderson de Sousa Munhoz Valim, Valéria Gomes, Ciro Martins Albuquerque, Cleandro Pires de Martins Filho, Olindo Assis Mota, Licia Maria Henrique da
author_role	author
author2	Sasaki, Lizandra Moura Paravidine Jardim-Santos, Gabriela Profírio Schulte, Heidi Luise Motta, Felipe Silva, Ângelo Pereira da Carvalho, Aleida Oliveira de Pereira, Yacara Ribeiro Alves, Caroline de Oliveira Araújo Júnior, David Alves de Mendonça-Silva, Dayde Lane Costa, Karina Nascimento Castro, Maria Eduarda Canellas de Lauand, Lucas Nery, Rodrigo de Resende Tristão, Rosana Kurizky, Patricia Shu Nóbrega, Otávio de Toledo Espindola, Laila Salmen Castro, Luiz Cláudio Gonçalves de Alpoim, Patrícia Nessralla Godoi, Lara Carvalho Dusse, Luci Maria Sant Ana Reis, Jordana Grazziela Alves Coelho Dos Amaral, Laurence Rodrigues do Gomes, Matheus de Souza Bertarini, Pedro Luiz Lima Sousa, Joaquim Pedro Brito de Rocha, Ismael Artur da Costa Azevedo, Ana Carolina Campi Pascoal, Vanessa Peruhype Magalhães Carvalho, Andrea Teixeira de Zaconeta, Alberto Moreno Soares, Alexandre Anderson de Sousa Munhoz Valim, Valéria Gomes, Ciro Martins Albuquerque, Cleandro Pires de Martins Filho, Olindo Assis Mota, Licia Maria Henrique da
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Fernandes, Geraldo Magela Sasaki, Lizandra Moura Paravidine Jardim-Santos, Gabriela Profírio Schulte, Heidi Luise Motta, Felipe Silva, Ângelo Pereira da Carvalho, Aleida Oliveira de Pereira, Yacara Ribeiro Alves, Caroline de Oliveira Araújo Júnior, David Alves de Mendonça-Silva, Dayde Lane Costa, Karina Nascimento Castro, Maria Eduarda Canellas de Lauand, Lucas Nery, Rodrigo de Resende Tristão, Rosana Kurizky, Patricia Shu Nóbrega, Otávio de Toledo Espindola, Laila Salmen Castro, Luiz Cláudio Gonçalves de Alpoim, Patrícia Nessralla Godoi, Lara Carvalho Dusse, Luci Maria Sant Ana Reis, Jordana Grazziela Alves Coelho Dos Amaral, Laurence Rodrigues do Gomes, Matheus de Souza Bertarini, Pedro Luiz Lima Sousa, Joaquim Pedro Brito de Rocha, Ismael Artur da Costa Azevedo, Ana Carolina Campi Pascoal, Vanessa Peruhype Magalhães Carvalho, Andrea Teixeira de Zaconeta, Alberto Moreno Soares, Alexandre Anderson de Sousa Munhoz Valim, Valéria Gomes, Ciro Martins Albuquerque, Cleandro Pires de Martins Filho, Olindo Assis Mota, Licia Maria Henrique da
dc.subject.en.en_US.fl_str_mv	COVID-19 chemokines cytokines growth factors pregnancy
topic	COVID-19 chemokines cytokines growth factors pregnancy
description	Universidade de Brasília. Programa de Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil
publishDate	2023
dc.date.accessioned.fl_str_mv	2023-05-11T14:18:13Z
dc.date.available.fl_str_mv	2023-05-11T14:18:13Z
dc.date.issued.fl_str_mv	2023
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	FERNANDES, Geraldo Magela et al. Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study. Frontiers in immunology, v. 14, 176898. doi: 10.3389/fimmu.2023.1176898.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/58318
dc.identifier.issn.en_US.fl_str_mv	1664-3224
identifier_str_mv	FERNANDES, Geraldo Magela et al. Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study. Frontiers in immunology, v. 14, 176898. doi: 10.3389/fimmu.2023.1176898. 1664-3224
url	https://www.arca.fiocruz.br/handle/icict/58318
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Frontiers Research Foundation
publisher.none.fl_str_mv	Frontiers Research Foundation
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/58318/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/58318/2/Panoramic%20snapshot%20of%20serum%20soluble%20mediator.pdf
bitstream.checksum.fl_str_mv	5a560609d32a3863062d77ff32785d58 2e3470db08ca9c5e5522ffbf8fd93b96
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1813009040213540864

Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study

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