PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion
| Main Author: | |
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| Publication Date: | 2009 |
| Other Authors: | , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://www.arca.fiocruz.br/handle/icict/10000 |
Summary: | Universidade Federal da Bahia. Instituo de Ciências da Saúde. Departamento de Biomorfologia. Salvador, BA, Brasil / Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Unidade de Microscopia Eletrônica. Salvador, BA, Brasil |
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Baptista, Abrahão FontesGoes, Bruno TeixeiraMenezes, Diego SilvaGomes, Flavia Carvalho AlcantaraCavalcanti, João ZugaibSilva, Joice StipurskyGomes, Joyce R. SOliveira, Julia TeixeiraSantos, Marcos André Vannier dosMartinez, Ana Maria Blanco2015-04-15T12:59:17Z2015-04-15T12:59:17Z2009BAPTISTA, A. F. et al. PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion. Journal of the Peripheral Nervous system, v. 14, n. 4, p. 285-293, 2009.1085-9489https://www.arca.fiocruz.br/handle/icict/1000010.1111/j.1529-8027.2009.00240.xengWoodland PublicationsPEMF fails to enhance nerve regeneration after sciatic nerve crush lesioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituo de Ciências da Saúde. Departamento de Biomorfologia. Salvador, BA, Brasil / Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Unidade de Microscopia Eletrônica. Salvador, BA, BrasilEscola Baiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Unidade de Microscopia Eletrônica. Salvador, BA, BrasilUniversidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, BrasilEscola Baiana de Medicina e Saúde Pública. Salvador, BA, BrasilUniversidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, BrasilEscola Baiana de Medicina e Saúde Pública. Salvador, BA, BrasilUniversidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Escola Baiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Unidade de Microscopia Eletrônica. Salvador, BA, BrasilUniversidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, BrasilThe use of electromagnetic fields has been reported to enhance peripheralnerve regeneration. This study aimed to identify the effects of a prolonged protocolof low-frequency pulsed electromagnetic field (PEMF) on peripheral nerve regeneration.Thirty-four male Swiss mice (Mus musculus) were divided into PEMF (n= 17) and control(n= 17) groups. All animals underwent a unilateral sciatic-crush lesion, and the PEMF groupwas exposed to a 72-Hz, 2-G electromagnetic field for 30 min, five days a week, for threeweeks. Functional analysis was carried out weekly. After three weeks, the animals wereeuthanized, and histological, morphometric, oxidative stress, and TGF-β1 analyses wereperformed. Functional analysis showed no differences between the groups. Histologicalappearance was similar between PEMF and control nerves. Morphometric assessmentshowed that the PEMF nerves trended toward decreased regeneration. The levels of freeradicals were more pronounced in PEMF nerves, but were not associated with an increasein the content of the TGF-β1/Smad signaling pathway. Prolonged PEMF regimen leads todelayed histological peripheral nerve regeneration and increased oxidative stress but noloss of function recoveryElectromagnetic fieldsMouseRegenerationSciatic nerve lesionTerapia de Campo MagnéticoRegeneração NervosaNervo IsquiáticoNeuropatia CiáticaCamundongosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10000/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALBaptista_et_al-2009-Journal_of_the_Peripheral_Nervous_System.pdfBaptista_et_al-2009-Journal_of_the_Peripheral_Nervous_System.pdfapplication/pdf793307https://www.arca.fiocruz.br/bitstream/icict/10000/2/Baptista_et_al-2009-Journal_of_the_Peripheral_Nervous_System.pdf45e5d4b828f10d79b645abffdb63c872MD52TEXTBaptista_et_al-2009-Journal_of_the_Peripheral_Nervous_System.pdf.txtBaptista_et_al-2009-Journal_of_the_Peripheral_Nervous_System.pdf.txtExtracted texttext/plain35033https://www.arca.fiocruz.br/bitstream/icict/10000/3/Baptista_et_al-2009-Journal_of_the_Peripheral_Nervous_System.pdf.txtc085815162c25930f91b8d62357d2748MD53icict/100002023-03-15 14:33:18.35oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| title |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| spellingShingle |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion Baptista, Abrahão Fontes Electromagnetic fields Mouse Regeneration Sciatic nerve lesion Terapia de Campo Magnético Regeneração Nervosa Nervo Isquiático Neuropatia Ciática Camundongos |
| title_short |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| title_full |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| title_fullStr |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| title_full_unstemmed |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| title_sort |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| author |
Baptista, Abrahão Fontes |
| author_facet |
Baptista, Abrahão Fontes Goes, Bruno Teixeira Menezes, Diego Silva Gomes, Flavia Carvalho Alcantara Cavalcanti, João Zugaib Silva, Joice Stipursky Gomes, Joyce R. S Oliveira, Julia Teixeira Santos, Marcos André Vannier dos Martinez, Ana Maria Blanco |
| author_role |
author |
| author2 |
Goes, Bruno Teixeira Menezes, Diego Silva Gomes, Flavia Carvalho Alcantara Cavalcanti, João Zugaib Silva, Joice Stipursky Gomes, Joyce R. S Oliveira, Julia Teixeira Santos, Marcos André Vannier dos Martinez, Ana Maria Blanco |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Baptista, Abrahão Fontes Goes, Bruno Teixeira Menezes, Diego Silva Gomes, Flavia Carvalho Alcantara Cavalcanti, João Zugaib Silva, Joice Stipursky Gomes, Joyce R. S Oliveira, Julia Teixeira Santos, Marcos André Vannier dos Martinez, Ana Maria Blanco |
| dc.subject.en.pt_BR.fl_str_mv |
Electromagnetic fields Mouse Regeneration Sciatic nerve lesion |
| topic |
Electromagnetic fields Mouse Regeneration Sciatic nerve lesion Terapia de Campo Magnético Regeneração Nervosa Nervo Isquiático Neuropatia Ciática Camundongos |
| dc.subject.decs.pt_BR.fl_str_mv |
Terapia de Campo Magnético Regeneração Nervosa Nervo Isquiático Neuropatia Ciática Camundongos |
| description |
Universidade Federal da Bahia. Instituo de Ciências da Saúde. Departamento de Biomorfologia. Salvador, BA, Brasil / Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Unidade de Microscopia Eletrônica. Salvador, BA, Brasil |
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2009 |
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2009 |
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2015-04-15T12:59:17Z |
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2015-04-15T12:59:17Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
BAPTISTA, A. F. et al. PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion. Journal of the Peripheral Nervous system, v. 14, n. 4, p. 285-293, 2009. |
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https://www.arca.fiocruz.br/handle/icict/10000 |
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1085-9489 |
| dc.identifier.doi.none.fl_str_mv |
10.1111/j.1529-8027.2009.00240.x |
| identifier_str_mv |
BAPTISTA, A. F. et al. PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion. Journal of the Peripheral Nervous system, v. 14, n. 4, p. 285-293, 2009. 1085-9489 10.1111/j.1529-8027.2009.00240.x |
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Woodland Publications |
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Woodland Publications |
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