PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/6165 |
Resumo: | Trabalho completo: acesso restrito, p. 285–293 |
| id |
UFBA-2_1ffe68dbe8d2589d9eb4bf28a1cc18ab |
|---|---|
| oai_identifier_str |
oai:repositorio.ufba.br:ri/6165 |
| network_acronym_str |
UFBA-2 |
| network_name_str |
Repositório Institucional da UFBA |
| repository_id_str |
1932 |
| spelling |
Baptista, Abrahão FontesGoes, Bruno TeixeiraMenezes, DiegoGomes, Flávia Carvalho AlcantaraZugaib, JoãoStipursky, JoiceGomes, Joyce R. S.Oliveira, Júlia TeixeiraSantos, Marcos André Vannier dosMartinez, Ana Maria BlancoBaptista, Abrahão FontesGoes, Bruno TeixeiraMenezes, DiegoGomes, Flávia Carvalho AlcantaraZugaib, JoãoStipursky, JoiceGomes, Joyce R. S.Oliveira, Júlia TeixeiraSantos, Marcos André Vannier dosMartinez, Ana Maria Blanco2012-06-15T20:09:37Z20091085-9489http://www.repositorio.ufba.br/ri/handle/ri/6165v. 14, n. 4Trabalho completo: acesso restrito, p. 285–293The use of electromagnetic fields has been reported to enhance peripheral nerve regeneration. This study aimed to identify the effects of a prolonged protocol of low-frequency pulsed electromagnetic field (PEMF) on peripheral nerve regeneration. Thirty-four male Swiss mice (Mus musculus) were divided into PEMF (n = 17) and control (n = 17) groups. All animals underwent a unilateral sciatic-crush lesion, and the PEMF group was exposed to a 72-Hz, 2-G electromagnetic field for 30 min, five days a week, for three weeks. Functional analysis was carried out weekly. After three weeks, the animals were euthanized, and histological, morphometric, oxidative stress, and TGF-β1 analyses were performed. Functional analysis showed no differences between the groups. Histological appearance was similar between PEMF and control nerves. Morphometric assessment showed that the PEMF nerves trended toward decreased regeneration. The levels of free radicals were more pronounced in PEMF nerves, but were not associated with an increase in the content of the TGF-β1/Smad signaling pathway. Prolonged PEMF regimen leads to delayed histological peripheral nerve regeneration and increased oxidative stress but no loss of function recovery.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-06-15T20:09:37Z No. of bitstreams: 1 (73)j.1529-8027.2009.00240.x.pdf: 793307 bytes, checksum: 45e5d4b828f10d79b645abffdb63c872 (MD5)Made available in DSpace on 2012-06-15T20:09:37Z (GMT). No. of bitstreams: 1 (73)j.1529-8027.2009.00240.x.pdf: 793307 bytes, checksum: 45e5d4b828f10d79b645abffdb63c872 (MD5) Previous issue date: 2009-12Wiley Blackwellhttp://onlinelibrary.wiley.com/doi/10.1111/j.1529-8027.2009.00240.x/pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAelectromagnetic fieldsmouseregenerationsciatic nerve lesionPEMF fails to enhance nerve regeneration after sciatic nerve crush lesionJournal of the Peripheral Nervous Systeminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL(73)j.1529-8027.2009.00240.x.pdf(73)j.1529-8027.2009.00240.x.pdfapplication/pdf793307https://repositorio.ufba.br/bitstream/ri/6165/1/%2873%29j.1529-8027.2009.00240.x.pdf45e5d4b828f10d79b645abffdb63c872MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6165/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT(73)j.1529-8027.2009.00240.x.pdf.txt(73)j.1529-8027.2009.00240.x.pdf.txtExtracted texttext/plain34738https://repositorio.ufba.br/bitstream/ri/6165/3/%2873%29j.1529-8027.2009.00240.x.pdf.txt626d5102f597cfc4290c3add3bb56933MD53ri/61652022-09-26 13:05:51.908oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-09-26T16:05:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of the Peripheral Nervous System |
| title |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| spellingShingle |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion Baptista, Abrahão Fontes electromagnetic fields mouse regeneration sciatic nerve lesion |
| title_short |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| title_full |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| title_fullStr |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| title_full_unstemmed |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| title_sort |
PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion |
| author |
Baptista, Abrahão Fontes |
| author_facet |
Baptista, Abrahão Fontes Goes, Bruno Teixeira Menezes, Diego Gomes, Flávia Carvalho Alcantara Zugaib, João Stipursky, Joice Gomes, Joyce R. S. Oliveira, Júlia Teixeira Santos, Marcos André Vannier dos Martinez, Ana Maria Blanco |
| author_role |
author |
| author2 |
Goes, Bruno Teixeira Menezes, Diego Gomes, Flávia Carvalho Alcantara Zugaib, João Stipursky, Joice Gomes, Joyce R. S. Oliveira, Júlia Teixeira Santos, Marcos André Vannier dos Martinez, Ana Maria Blanco |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Baptista, Abrahão Fontes Goes, Bruno Teixeira Menezes, Diego Gomes, Flávia Carvalho Alcantara Zugaib, João Stipursky, Joice Gomes, Joyce R. S. Oliveira, Júlia Teixeira Santos, Marcos André Vannier dos Martinez, Ana Maria Blanco Baptista, Abrahão Fontes Goes, Bruno Teixeira Menezes, Diego Gomes, Flávia Carvalho Alcantara Zugaib, João Stipursky, Joice Gomes, Joyce R. S. Oliveira, Júlia Teixeira Santos, Marcos André Vannier dos Martinez, Ana Maria Blanco |
| dc.subject.por.fl_str_mv |
electromagnetic fields mouse regeneration sciatic nerve lesion |
| topic |
electromagnetic fields mouse regeneration sciatic nerve lesion |
| description |
Trabalho completo: acesso restrito, p. 285–293 |
| publishDate |
2009 |
| dc.date.issued.fl_str_mv |
2009 |
| dc.date.accessioned.fl_str_mv |
2012-06-15T20:09:37Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/6165 |
| dc.identifier.issn.none.fl_str_mv |
1085-9489 |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 14, n. 4 |
| identifier_str_mv |
1085-9489 v. 14, n. 4 |
| url |
http://www.repositorio.ufba.br/ri/handle/ri/6165 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Wiley Blackwell |
| publisher.none.fl_str_mv |
Wiley Blackwell |
| dc.source.pt_BR.fl_str_mv |
http://onlinelibrary.wiley.com/doi/10.1111/j.1529-8027.2009.00240.x/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
| instname_str |
Universidade Federal da Bahia (UFBA) |
| instacron_str |
UFBA |
| institution |
UFBA |
| reponame_str |
Repositório Institucional da UFBA |
| collection |
Repositório Institucional da UFBA |
| bitstream.url.fl_str_mv |
https://repositorio.ufba.br/bitstream/ri/6165/1/%2873%29j.1529-8027.2009.00240.x.pdf https://repositorio.ufba.br/bitstream/ri/6165/2/license.txt https://repositorio.ufba.br/bitstream/ri/6165/3/%2873%29j.1529-8027.2009.00240.x.pdf.txt |
| bitstream.checksum.fl_str_mv |
45e5d4b828f10d79b645abffdb63c872 1b89a9a0548218172d7c829f87a0eab9 626d5102f597cfc4290c3add3bb56933 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA) |
| repository.mail.fl_str_mv |
|
| _version_ |
1798057578804019200 |