Transmission of Hepatitis B and D Viruses in an African Rural Community
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1128/mSystems.00120-18 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31269 |
Resumo: | Swiss Tropical and Public Health Institute. Molecular Immunology. Basel, Switzerland / University of Basel. Basel, Switzerland / Universidade Federal Fluminense. Instituto de Biologia. Laboratório de Virologia Molecular. Niterói, RJ, Brasil. |
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Nascimento, Carlos Augusto PinhoBratschi, Martin W.Höfer, ReneSoares, Caroline CordeiroWarryn, LouisaPečerska, JūlijaMinyem, Jacques C.Paixão, Izabel C. N. P.Moraes, Marcia Terezinha Baroni deUm Boock, AlphonseNiel, ChristianPluschke, GerdRöltgen, Katharina2019-01-24T10:22:55Z2019-01-24T10:22:55Z2018NASCIMENTO, Carlos Augusto Pinho; et al. Transmission of Hepatitis B and D Viruses in an African Rural Community. mSystems, v.3, n.5, e00120-18, 15p, 2018.2379-5077https://www.arca.fiocruz.br/handle/icict/3126910.1128/mSystems.00120-18engAmerican Society for MicrobiologyVírus da Hepatite BEpidemiologia molecularTransmissãoÁfricaComunidades ruraisHepatitis B virusMolecular epidemiologyTransmissionAfricaRural communitiesTransmission of Hepatitis B and D Viruses in an African Rural Communityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSwiss Tropical and Public Health Institute. Molecular Immunology. Basel, Switzerland / University of Basel. Basel, Switzerland / Universidade Federal Fluminense. Instituto de Biologia. Laboratório de Virologia Molecular. Niterói, RJ, Brasil.Swiss Tropical and Public Health Institute. Molecular Immunology. Basel, Switzerland / University of Basel. Basel, Switzerland.Jena-Optronik GmbH. Jena, Germany.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.Swiss Tropical and Public Health Institute. Molecular Immunology. Basel, Switzerland / University of Basel. Basel, Switzerland.Department of Biosystems Science and Engineering. ETH Zürich. Basel, Switzerland.FAIRMED., Yaoundé, Cameroon.Universidade Federal Fluminense. Instituto de Biologia. Laboratório de Virologia Molecular. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ. Brasil.FAIRMED., Yaoundé, Cameroon.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.Swiss Tropical and Public Health Institute. Molecular Immunology. Basel, Switzerland / University of Basel. Basel, Switzerland.Swiss Tropical and Public Health Institute. Molecular Immunology. Basel, Switzerland / University of Basel. Basel, Switzerland.According to the World Health Organization (WHO), an estimated 257 million people worldwide are chronically infected with hepatitis B virus (HBV), with approximately 15 million of them being coinfected with hepatitis D virus (HDV). To investigate the prevalence and transmission of HBV and HDV within the general population of a rural village in Cameroon, we analyzed serum samples from most (401/448) of the villagers. HBV surface antigen (HBsAg) was detected in 54 (13.5%) of the 401 samples, with 15% of them also containing anti-HDV antibodies. Although Cameroon has integrated HBV vaccination into their Expanded Program on Immunization for newborns in 2005, an HBsAg carriage rate of 5% was found in children below the age of 5 years. Of the 54 HBsAg-positive samples, 49 HBV pre-S/S sequences (7 genotype A and 42 genotype E sequences) could be amplified by PCR. In spite of the extreme geographical restriction in the recruitment of study participants, a remarkable genetic diversity within HBV genotypes was observed. Phylogenetic analysis of the sequences obtained from PCR products combined with demographic information revealed that the presence of some genetic variants was restricted to members of one household, indicative of intrafamilial transmission, which appears to take place at least in part perinatally from mother to child. Other genetic variants were more widely distributed, reflecting horizontal interhousehold transmission. Data for two households with more than one HBV-HDV-coinfected individual indicate that the two viruses are not necessarily transmitted together, as family members with identical HBV sequences had different HDV statuses. IMPORTANCE This study revealed that the prevalence of HBV and HDV in a rural area of Cameroon is extremely high, underlining the pressing need for the improvement of control strategies. Systematic serological and phylogenetic analyses of HBV sequences turned out to be useful tools to identify networks of virus transmission within and between households. The high HBsAg carriage rate found among children demonstrates that implementation of the HBV birth dose vaccine and improvement of vaccine coverage will be key elements in preventing both HBV and HDV infections. In addition, the high HBsAg carriage rate in adolescents and adults emphasizes the need for identification of chronically infected individuals and linkage to WHO-recommended treatment to prevent progression to liver cirrhosis and hepatocellular carcinoma.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31269/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALchristian_neil_etal_IOC_2018.pdfchristian_neil_etal_IOC_2018.pdfapplication/pdf3290652https://www.arca.fiocruz.br/bitstream/icict/31269/2/christian_neil_etal_IOC_2018.pdf64ef54693cfa2ab773fdfb814a92a47dMD52TEXTchristian_neil_etal_IOC_2018.pdf.txtchristian_neil_etal_IOC_2018.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Transmission of Hepatitis B and D Viruses in an African Rural Community |
| title |
Transmission of Hepatitis B and D Viruses in an African Rural Community |
| spellingShingle |
Transmission of Hepatitis B and D Viruses in an African Rural Community Nascimento, Carlos Augusto Pinho Vírus da Hepatite B Epidemiologia molecular Transmissão África Comunidades rurais Hepatitis B virus Molecular epidemiology Transmission Africa Rural communities |
| title_short |
Transmission of Hepatitis B and D Viruses in an African Rural Community |
| title_full |
Transmission of Hepatitis B and D Viruses in an African Rural Community |
| title_fullStr |
Transmission of Hepatitis B and D Viruses in an African Rural Community |
| title_full_unstemmed |
Transmission of Hepatitis B and D Viruses in an African Rural Community |
| title_sort |
Transmission of Hepatitis B and D Viruses in an African Rural Community |
| author |
Nascimento, Carlos Augusto Pinho |
| author_facet |
Nascimento, Carlos Augusto Pinho Bratschi, Martin W. Höfer, Rene Soares, Caroline Cordeiro Warryn, Louisa Pečerska, Jūlija Minyem, Jacques C. Paixão, Izabel C. N. P. Moraes, Marcia Terezinha Baroni de Um Boock, Alphonse Niel, Christian Pluschke, Gerd Röltgen, Katharina |
| author_role |
author |
| author2 |
Bratschi, Martin W. Höfer, Rene Soares, Caroline Cordeiro Warryn, Louisa Pečerska, Jūlija Minyem, Jacques C. Paixão, Izabel C. N. P. Moraes, Marcia Terezinha Baroni de Um Boock, Alphonse Niel, Christian Pluschke, Gerd Röltgen, Katharina |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Nascimento, Carlos Augusto Pinho Bratschi, Martin W. Höfer, Rene Soares, Caroline Cordeiro Warryn, Louisa Pečerska, Jūlija Minyem, Jacques C. Paixão, Izabel C. N. P. Moraes, Marcia Terezinha Baroni de Um Boock, Alphonse Niel, Christian Pluschke, Gerd Röltgen, Katharina |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus da Hepatite B Epidemiologia molecular Transmissão África Comunidades rurais |
| topic |
Vírus da Hepatite B Epidemiologia molecular Transmissão África Comunidades rurais Hepatitis B virus Molecular epidemiology Transmission Africa Rural communities |
| dc.subject.en.pt_BR.fl_str_mv |
Hepatitis B virus Molecular epidemiology Transmission Africa Rural communities |
| description |
Swiss Tropical and Public Health Institute. Molecular Immunology. Basel, Switzerland / University of Basel. Basel, Switzerland / Universidade Federal Fluminense. Instituto de Biologia. Laboratório de Virologia Molecular. Niterói, RJ, Brasil. |
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2018 |
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2018 |
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2019-01-24T10:22:55Z |
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2019-01-24T10:22:55Z |
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NASCIMENTO, Carlos Augusto Pinho; et al. Transmission of Hepatitis B and D Viruses in an African Rural Community. mSystems, v.3, n.5, e00120-18, 15p, 2018. |
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https://www.arca.fiocruz.br/handle/icict/31269 |
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2379-5077 |
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10.1128/mSystems.00120-18 |
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NASCIMENTO, Carlos Augusto Pinho; et al. Transmission of Hepatitis B and D Viruses in an African Rural Community. mSystems, v.3, n.5, e00120-18, 15p, 2018. 2379-5077 10.1128/mSystems.00120-18 |
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American Society for Microbiology |
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American Society for Microbiology |
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