Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies

Detalhes bibliográficos
Autor(a) principal: Oliveira, Geraldo Gileno de Sá
Data de Publicação: 1994
Outros Autores: Hutchings, P. R, Roitt, I. M, Lydyard, P. M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20417
Resumo: Oliveira, Geraldo Gileno de Sá “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
id CRUZ_7ce1d072178d44bfecec695b0be18493
oai_identifier_str oai:www.arca.fiocruz.br:icict/20417
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Oliveira, Geraldo Gileno de SáHutchings, P. RRoitt, I. MLydyard, P. M2017-07-26T18:11:52Z2017-07-26T18:11:52Z1994OLIVEIRA, G. G. S. et al. Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies. Clinical Experimental Immunology, v. 96, n. 2, p. 297-302, 1994.0009-9104https://www.arca.fiocruz.br/handle/icict/20417Oliveira, Geraldo Gileno de Sá “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Brazilian Council for Development of Research and Technology (CNPq).University College London Medical School. London, UKUniversity College London Medical School. London, UKUniversity College London Medical School. London, UKUniversity College London Medical School. London, UKNZB mice spontaneously develop haemolytic anaemia as the result of production of erythrocyte autoantibodies. The mechanisms leading to breakdown in tolerance to erythrocyte autoantigens are unknown. Antibodies to CD4 have been successfully used to treat several murine models of autoimmune disease. In this study we injected NZB mice with non-depleting CD4 antibodies and were able to prevent and abrogate erythrocyte autoantibody production in young (Coombs' negative) and old (Coombs' positive) mice, respectively. Our data indicate the dependency of autoantibody production on CD4+ T cells. However, withdrawal of anti-CD4 antibodies resulted in the appearance of erythrocyte autoantibodies, showing that under these conditions we were unable to re-establish tolerance to autoantigens on erythrocytes using anti-CD4 treatment.engWileyRatosDoenças autoimunesAnticorposAntígeno CD4NZB miceTherapy of autoimmune diseaseAnti-CD4 antibodiesProduction of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20417/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOliveira GGS Production of erythrocyte autoantibodies.....pdfOliveira GGS Production of erythrocyte autoantibodies.....pdfapplication/pdf1022373https://www.arca.fiocruz.br/bitstream/icict/20417/2/Oliveira%20GGS%20Production%20of%20erythrocyte%20autoantibodies.....pdf2996b2d3dbe278832a8fc685de1cd7afMD52TEXTOliveira GGS Production of erythrocyte autoantibodies.....pdf.txtOliveira GGS Production of erythrocyte autoantibodies.....pdf.txtExtracted texttext/plain29353https://www.arca.fiocruz.br/bitstream/icict/20417/3/Oliveira%20GGS%20Production%20of%20erythrocyte%20autoantibodies.....pdf.txt13ca869fb992d07ce1dd073ecbfdc810MD53icict/204172023-03-15 14:34:11.018oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:11Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies
title Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies
spellingShingle Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies
Oliveira, Geraldo Gileno de Sá
Ratos
Doenças autoimunes
Anticorpos
Antígeno CD4
NZB mice
Therapy of autoimmune disease
Anti-CD4 antibodies
title_short Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies
title_full Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies
title_fullStr Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies
title_full_unstemmed Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies
title_sort Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies
author Oliveira, Geraldo Gileno de Sá
author_facet Oliveira, Geraldo Gileno de Sá
Hutchings, P. R
Roitt, I. M
Lydyard, P. M
author_role author
author2 Hutchings, P. R
Roitt, I. M
Lydyard, P. M
author2_role author
author
author
dc.contributor.author.fl_str_mv Oliveira, Geraldo Gileno de Sá
Hutchings, P. R
Roitt, I. M
Lydyard, P. M
dc.subject.other.pt_BR.fl_str_mv Ratos
Doenças autoimunes
Anticorpos
Antígeno CD4
topic Ratos
Doenças autoimunes
Anticorpos
Antígeno CD4
NZB mice
Therapy of autoimmune disease
Anti-CD4 antibodies
dc.subject.en.pt_BR.fl_str_mv NZB mice
Therapy of autoimmune disease
Anti-CD4 antibodies
description Oliveira, Geraldo Gileno de Sá “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 1994
dc.date.issued.fl_str_mv 1994
dc.date.accessioned.fl_str_mv 2017-07-26T18:11:52Z
dc.date.available.fl_str_mv 2017-07-26T18:11:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, G. G. S. et al. Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies. Clinical Experimental Immunology, v. 96, n. 2, p. 297-302, 1994.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20417
dc.identifier.issn.pt_BR.fl_str_mv 0009-9104
identifier_str_mv OLIVEIRA, G. G. S. et al. Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies. Clinical Experimental Immunology, v. 96, n. 2, p. 297-302, 1994.
0009-9104
url https://www.arca.fiocruz.br/handle/icict/20417
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/20417/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/20417/2/Oliveira%20GGS%20Production%20of%20erythrocyte%20autoantibodies.....pdf
https://www.arca.fiocruz.br/bitstream/icict/20417/3/Oliveira%20GGS%20Production%20of%20erythrocyte%20autoantibodies.....pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
2996b2d3dbe278832a8fc685de1cd7af
13ca869fb992d07ce1dd073ecbfdc810
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009075828424704

Registros relacionados