The importance of airway and lung microbiome in the critically ill

Detalhes bibliográficos
Autor(a) principal: Martin-Loeches, Ignacio
Data de Publicação: 2020
Outros Autores: Dickson, Robert, Torres, Antoni, Hanberger, Håkan, Lipman, Jeffrey, Antonelli, Massimo, Pascale, Gennaro de, Bozza, Fernando, Vincent, Jean Louis, Murthy, Srinivas, Bauer, Michael, Marshall, John, Cilloniz, Catia, Bos, Lieuwe D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44243
Resumo: St James Hospital. Multidisciplinary Intensive Care Research Organization. Department of Intensive Care Medicine. Dublin, Ireland / CIBERes. IDIBAPS. Hospital Clinic. Department of Respiratory Medicine. Barcelona, Spain / Trinity College. Dublin, Ireland.
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spelling Martin-Loeches, IgnacioDickson, RobertTorres, AntoniHanberger, HåkanLipman, JeffreyAntonelli, MassimoPascale, Gennaro deBozza, FernandoVincent, Jean LouisMurthy, SrinivasBauer, MichaelMarshall, JohnCilloniz, CatiaBos, Lieuwe D.2020-10-28T14:29:00Z2020-10-28T14:29:00Z2020MARTIN-LOECHES, Ignacio et al. The importance of airway and lung microbiome in the critically ill. Critical care. v. 24, n. 1, p. 1-9, 2020.1364-8535https://www.arca.fiocruz.br/handle/icict/4424310.1186/s13054-020-03219-4engSpringerThe importance of airway and lung microbiome in the critically illinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSt James Hospital. Multidisciplinary Intensive Care Research Organization. Department of Intensive Care Medicine. Dublin, Ireland / CIBERes. IDIBAPS. Hospital Clinic. Department of Respiratory Medicine. Barcelona, Spain / Trinity College. Dublin, Ireland.University of Michigan. Department of Internal Medicine. Division of Pulmonary and Critical Care Medicine. Ann Arbor, MI, USA / University of Michigan. Department of Microbiology and Immunology. Ann Arbor, MI, USA / Michigan Center for Integrative Research in Critical Care. Ann Arbor, MI, USA.Hospital Clinic of Barcelona. Institut Clinic del Tórax. Deparment of Pneumology. Barcelona, Spain / University of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Barcelona, Spain / Ciber de Enfermedades Respiratorias. Barcelona, Spain.Linköping University. Department of Infectious Diseases. Linköping, Sweden / Linköping University. Department of Clinical and Experimental Medicine. Linköping, Sweden.The University of Queensland. Brisbane, Australia / University of Montpellier. Nimes University Hospital. Scientific Consultant. Nimes, France.Fondazione Policlinico Universitario A. Gemelli IRCCS. Intensive Care and Emergency Medicine. Department of Anesthesiology. Rome, Italy / Università Cattolica del Sacro Cuore. Rome, Italy.Fondazione Policlinico Universitario A. Gemelli IRCCS. Intensive Care and Emergency Medicine. Department of Anesthesiology. Rome, Italy / Università Cattolica del Sacro Cuore. Rome, Italy.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Université Libre de Bruxelles. Erasme University Hospital. Department of Intensive Care. Brussels, Belgium.University of British Columbia. Vancouver, BC, Canada.Jena University Hospital. Department of Anesthesiology and Intensive Care Medicine. Am Klinikum, Jena, Germany.University of Toronto. St Michael's Hospital. The Li Ka Shing Knowledge Institute. The Keenan Research Centre for Biomedical Science. Toronto, Ontario, Canada.Hospital Clinic of Barcelona. Institut Clinic del Tórax. Deparment of Pneumology. Barcelona, Spain / University of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Barcelona, Spain / Ciber de Enfermedades Respiratorias. Barcelona, Spain.Amsterdam University Medical Center. Infection and Immunity. Department of Respiratory Medicine. Amsterdam, The Netherlands.During critical illness, there are a multitude of forces such as antibiotic use, mechanical ventilation, diet changes and inflammatory responses that could bring the microbiome out of balance. This so-called dysbiosis of the microbiome seems to be involved in immunological responses and may influence outcomes even in individuals who are not as vulnerable as a critically ill ICU population. It is therefore probable that dysbiosis of the microbiome is a consequence of critical illness and may, subsequently, shape an inadequate response to these circumstances.Bronchoscopic studies have revealed that the carina represents the densest site of bacterial DNA along healthy airways, with a tapering density with further bifurcations. This likely reflects the influence of micro-aspiration as the primary route of microbial immigration in healthy adults. Though bacterial DNA density grows extremely sparse at smaller airways, bacterial signal is still consistently detectable in bronchoalveolar lavage fluid, likely reflecting the fact that lavage via a wedged bronchoscope samples an enormous surface area of small airways and alveoli. The dogma of lung sterility also violated numerous observations that long predated culture-independent microbiology.The body's resident microbial consortia (gut and/or respiratory microbiota) affect normal host inflammatory and immune response mechanisms. Disruptions in these host-pathogen interactions have been associated with infection and altered innate immunity.In this narrative review, we will focus on the rationale and current evidence for a pathogenic role of the lung microbiome in the exacerbation of complications of critical illness, such as acute respiratory distress syndrome and ventilator-associated pneumonia.InfectionMicrobiomePneumoniaVentilator-associated pneumoniaVentilator-associated tracheobronchitisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/44243/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALThe importance_Fernando_Bozza_etal_INI_2020.pdfThe 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dc.title.pt_BR.fl_str_mv The importance of airway and lung microbiome in the critically ill
title The importance of airway and lung microbiome in the critically ill
spellingShingle The importance of airway and lung microbiome in the critically ill
Martin-Loeches, Ignacio
Infection
Microbiome
Pneumonia
Ventilator-associated pneumonia
Ventilator-associated tracheobronchitis
title_short The importance of airway and lung microbiome in the critically ill
title_full The importance of airway and lung microbiome in the critically ill
title_fullStr The importance of airway and lung microbiome in the critically ill
title_full_unstemmed The importance of airway and lung microbiome in the critically ill
title_sort The importance of airway and lung microbiome in the critically ill
author Martin-Loeches, Ignacio
author_facet Martin-Loeches, Ignacio
Dickson, Robert
Torres, Antoni
Hanberger, Håkan
Lipman, Jeffrey
Antonelli, Massimo
Pascale, Gennaro de
Bozza, Fernando
Vincent, Jean Louis
Murthy, Srinivas
Bauer, Michael
Marshall, John
Cilloniz, Catia
Bos, Lieuwe D.
author_role author
author2 Dickson, Robert
Torres, Antoni
Hanberger, Håkan
Lipman, Jeffrey
Antonelli, Massimo
Pascale, Gennaro de
Bozza, Fernando
Vincent, Jean Louis
Murthy, Srinivas
Bauer, Michael
Marshall, John
Cilloniz, Catia
Bos, Lieuwe D.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Martin-Loeches, Ignacio
Dickson, Robert
Torres, Antoni
Hanberger, Håkan
Lipman, Jeffrey
Antonelli, Massimo
Pascale, Gennaro de
Bozza, Fernando
Vincent, Jean Louis
Murthy, Srinivas
Bauer, Michael
Marshall, John
Cilloniz, Catia
Bos, Lieuwe D.
dc.subject.en.pt_BR.fl_str_mv Infection
Microbiome
Pneumonia
Ventilator-associated pneumonia
Ventilator-associated tracheobronchitis
topic Infection
Microbiome
Pneumonia
Ventilator-associated pneumonia
Ventilator-associated tracheobronchitis
description St James Hospital. Multidisciplinary Intensive Care Research Organization. Department of Intensive Care Medicine. Dublin, Ireland / CIBERes. IDIBAPS. Hospital Clinic. Department of Respiratory Medicine. Barcelona, Spain / Trinity College. Dublin, Ireland.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-10-28T14:29:00Z
dc.date.available.fl_str_mv 2020-10-28T14:29:00Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARTIN-LOECHES, Ignacio et al. The importance of airway and lung microbiome in the critically ill. Critical care. v. 24, n. 1, p. 1-9, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44243
dc.identifier.issn.pt_BR.fl_str_mv 1364-8535
dc.identifier.doi.none.fl_str_mv 10.1186/s13054-020-03219-4
identifier_str_mv MARTIN-LOECHES, Ignacio et al. The importance of airway and lung microbiome in the critically ill. Critical care. v. 24, n. 1, p. 1-9, 2020.
1364-8535
10.1186/s13054-020-03219-4
url https://www.arca.fiocruz.br/handle/icict/44243
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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