Resialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytes

Detalhes bibliográficos
Autor(a) principal: Tomlinson, Stephen
Data de Publicação: 1992
Outros Autores: Pontes-de-Carvalho, Lain Carlos, Vandekerckhove, Filip, Nussenzweig, Victor
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32292
Resumo: Pontes-de-Carvalho, Lain Carlos. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Tomlinson, StephenPontes-de-Carvalho, Lain CarlosVandekerckhove, FilipNussenzweig, Victor2019-03-29T13:27:36Z2019-03-29T13:27:36Z1992TOMLINSON, S. et al. Resialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytes. Glycobiology, v. 2, n. 6, p. 549-551, 1992.0959-6658https://www.arca.fiocruz.br/handle/icict/32292Pontes-de-Carvalho, Lain Carlos. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.N1H grant AI32966, by the John D. and Catherine T.MacArthur Foundation, by the United Nations Development Program/World Health Organization Special Program for Research and Training in Tropical Diseases, and by the Rockefeller Foundation. F.V. is a research assistant of the Belgian National Fund for Scientific Research and L.P.C. is a senior investigator of the Oswaldo Cruz Foundation and is a recipient of a grant from the RHAE program, Secretary of Science and Technology, Brazil.New York University Medical Center. Department of Pathology. New York, NY, USA.New York University Medical Center. Department of Pathology. New York, NY, USA.New York University Medical Center. Department of Pathology. New York, NY, USA.New York University Medical Center. Department of Pathology. New York, NY, USA.Trypanosoma cruzi trans-sialidase (TS) is a recently described enzyme whkh transfers a(2-3)-linked sialic acid from host-derived sialylated glycoconjugates to parasite surface molecules [Schenkman et al. (1991) Cell, 65, 1117]. We report here on the ability of TS to transfer sialic acid from donor sialyl-a(2-3)lactose to sialidase-treated sheep and human erythrocytes. Up to ~ 50% resialylation of both desialylated red cells could be attained. Resialylation of desialylated sheep erythrocytes restores their resistance to lysis by human complement. This ascribes a possible biological role for T.cruzi TS and demonstrates directly that sialic acid is solely responsible for preventing alternative pathway activation of human complement by sheep erythrocytes.engOxford University PressTrypanosoma cruziEritrócitosComplementoÁcido sialidaseAcido sialicoTrans-sialidaseTrypanosoma cruziErythrocytesComplementAcid sialidaseSialic acidTrans-sialidaseResialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32292/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTomlinson S Resialylation of sialidase-treated.. 1992.pdfTomlinson S Resialylation of sialidase-treated.. 1992.pdfapplication/pdf340642https://www.arca.fiocruz.br/bitstream/icict/32292/2/Tomlinson%20S%20Resialylation%20of%20sialidase-treated..%201992.pdf01e6870d9166a3f35af250103520258eMD52TEXTTomlinson S Resialylation of sialidase-treated.. 1992.pdf.txtTomlinson S Resialylation of sialidase-treated.. 1992.pdf.txtExtracted texttext/plain20145https://www.arca.fiocruz.br/bitstream/icict/32292/3/Tomlinson%20S%20Resialylation%20of%20sialidase-treated..%201992.pdf.txt16ad282276c566334d169b608a64f85fMD53icict/322922023-03-15 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dc.title.pt_BR.fl_str_mv Resialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytes
title Resialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytes
spellingShingle Resialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytes
Tomlinson, Stephen
Trypanosoma cruzi
Eritrócitos
Complemento
Ácido sialidase
Acido sialico
Trans-sialidase
Trypanosoma cruzi
Erythrocytes
Complement
Acid sialidase
Sialic acid
Trans-sialidase
title_short Resialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytes
title_full Resialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytes
title_fullStr Resialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytes
title_full_unstemmed Resialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytes
title_sort Resialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytes
author Tomlinson, Stephen
author_facet Tomlinson, Stephen
Pontes-de-Carvalho, Lain Carlos
Vandekerckhove, Filip
Nussenzweig, Victor
author_role author
author2 Pontes-de-Carvalho, Lain Carlos
Vandekerckhove, Filip
Nussenzweig, Victor
author2_role author
author
author
dc.contributor.author.fl_str_mv Tomlinson, Stephen
Pontes-de-Carvalho, Lain Carlos
Vandekerckhove, Filip
Nussenzweig, Victor
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Eritrócitos
Complemento
Ácido sialidase
Acido sialico
Trans-sialidase
topic Trypanosoma cruzi
Eritrócitos
Complemento
Ácido sialidase
Acido sialico
Trans-sialidase
Trypanosoma cruzi
Erythrocytes
Complement
Acid sialidase
Sialic acid
Trans-sialidase
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Erythrocytes
Complement
Acid sialidase
Sialic acid
Trans-sialidase
description Pontes-de-Carvalho, Lain Carlos. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2019-03-29T13:27:36Z
dc.date.available.fl_str_mv 2019-03-29T13:27:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TOMLINSON, S. et al. Resialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytes. Glycobiology, v. 2, n. 6, p. 549-551, 1992.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32292
dc.identifier.issn.pt_BR.fl_str_mv 0959-6658
identifier_str_mv TOMLINSON, S. et al. Resialylation of sialidase-treated sheep and human erythrocytes by Trypanosoma cruzi trans-sialidase: restoration of complement resistance of desialylated sheep erythrocytes. Glycobiology, v. 2, n. 6, p. 549-551, 1992.
0959-6658
url https://www.arca.fiocruz.br/handle/icict/32292
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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