Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data

Schaefer, Robin; Leite, Pedro Henrique Amparo da Costa; Silva, Ronaldo; Karim, Quarraisha Abdool; Akolo, Christopher; Cáceres, Carlos F.; Dourado, Inês; Green, Kimberly; Hettema, Anita; Hoornenborg, Elske; Jana, Smarajit; Kerschberger, Bernhard; Mahler, Hally; Matse, Sindy; McManus, Hamish; Molina, Jean-Michel; Reza-Paul, Sushena; Azwa, Iskandar; Shahmanesh, Maryam; Taylor, Doug; Vega-Ramirez, Hamid; Veloso, Valdiléa G.; Baggaley, Rachel; Dalal, Shona

Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data

Detalhes bibliográficos
Autor(a) principal:	Schaefer, Robin
Data de Publicação:	2022
Outros Autores:	Leite, Pedro Henrique Amparo da Costa, Silva, Ronaldo, Karim, Quarraisha Abdool, Akolo, Christopher, Cáceres, Carlos F., Dourado, Inês, Green, Kimberly, Hettema, Anita, Hoornenborg, Elske, Jana, Smarajit, Kerschberger, Bernhard, Mahler, Hally, Matse, Sindy, McManus, Hamish, Molina, Jean-Michel, Reza-Paul, Sushena, Azwa, Iskandar, Shahmanesh, Maryam, Taylor, Doug, Vega-Ramirez, Hamid, Veloso, Valdiléa G., Baggaley, Rachel, Dalal, Shona
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/52917
Resumo:	Unitaid, Bill & Melinda Gates Foundation, WHO.

Metadados do item

id	CRUZ_7dd61e2ad8c4750bfcb0f0aaab933730
oai_identifier_str	oai:www.arca.fiocruz.br:icict/52917
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Schaefer, RobinLeite, Pedro Henrique Amparo da CostaSilva, RonaldoKarim, Quarraisha AbdoolAkolo, ChristopherCáceres, Carlos F.Dourado, InêsGreen, KimberlyHettema, AnitaHoornenborg, ElskeJana, SmarajitKerschberger, BernhardMahler, HallyMatse, SindyMcManus, HamishMolina, Jean-MichelReza-Paul, SushenaAzwa, IskandarShahmanesh, MaryamTaylor, DougVega-Ramirez, HamidVeloso, Valdiléa G.Baggaley, RachelDalal, Shona2022-05-26T00:39:57Z2022-05-26T00:39:57Z2022SCHAEFER, Robin et al. Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data. The lancet. HIV, v. 9, n. 4, p. e242-e253, 20222405-4704https://www.arca.fiocruz.br/handle/icict/5291710.1016/S2352-3018(22)00004-2Unitaid, Bill & Melinda Gates Foundation, WHO.World Health Organization. Hepatitis and STIs Programmes. Global HIV. Geneva, Switzerland.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.IRCCS Sacro Cuore Don Calabria Hospital. Department of Infectious-Tropical Diseases and Microbiology. Negrar, Italy.Nelson R Mandela School of Medicine. CAPRISA. Durban, South Africa / University of KwaZulu-Natal. Durban, South Africa.FHI 360. Washington, DC, USA.Universidad Cayetano Heredia. Centro de Investigación Interdisciplinaria en Sexualidad, SIDA y Sociedad. Lima, Peru.Federal University of Bahia. Collective Health Institute. Salvador, BA, Brazil.PATH Vietnam. Hanoi, Vietnam.Clinton Health Access Initiative. Mbabane, Eswatini.Public Health Service Amsterdam. Department of Infectious Diseases. Center for Sexual Health. Amsterdam, Netherlands.Durbar Mahilla Samanwaya Committee. Kolkata, India.Médecins Sans Frontières. Mbabane, Eswatini.FHI 360. Washington, DC, USA.National AIDS Programme. Mbabane, Eswatini.University of New South Wales Sydney. The Kirby Institute. Sydney, NSW, Australia.University of Paris. St-Louis and Lariboisière Hospitals. Department of Infectious Diseases. Paris, France.University of Manitoba. Department of Community Health Sciences. Winnipeg, MB, Canada / Ashodaya Samithi. Mysuru, India.University of Malaya. Faculty of Medicine. Infectious Diseases Unit. Kuala Lumpur, Malaysia.Africa Health Research Institute. KwaZulu-Natal, South Africa / University College London. Institute for Global Health. London, UK.FHI 360. Durham, NC, USA.National Institute of Psychiatry Ramon de la Fuente Muñiz. Mexico City, Mexico.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.World Health Organization. Hepatitis and STIs Programmes. Global HIV. Geneva, Switzerland.World Health Organization. Hepatitis and STIs Programmes. Global HIV. Geneva, Switzerland.Background: Previous WHO guidance on tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis (PrEP) suggests measuring creatinine levels at PrEP initiation and regularly afterwards, which might represent barriers to PrEP implementation and uptake. We aimed to systematically review published literature on kidney toxicity among tenofovir disoproxil fumarate-based oral PrEP users and conducted an individual participant data meta-analysis (IPDMA) on kidney function among PrEP users in a global implementation project dataset. Methods: In this systematic review and meta-analysis we searched PubMed up to June 30, 2021, for randomised controlled trials (RCTs) or cohort studies that reported on graded kidney-related adverse events among oral PrEP users (tenofovir disoproxil fumarate-based PrEP alone or in combination with emtricitabine or lamivudine). We extracted summary data and conducted meta-analyses with random-effects models to estimate relative risks of grade 1 and higher and grade 2 and higher kidney-related adverse events, measured by elevated serum creatinine or decline in estimated creatinine clearance or estimated glomerular filtration rate. The IPDMA included (largely unpublished) individual participant data from 17 PrEP implementation projects and two RCTs. Estimated baseline creatinine clearance and creatinine clearance change after initiation were described by age, gender, and comorbidities. We used random-effects regressions to estimate the risk in decline of creatinine clearance to less than 60 mL/min. Findings: We identified 62 unique records and included 17 articles reporting on 11 RCTs with 13 523 participants in meta-analyses. PrEP use was associated with increased risk of grade 1 and higher kidney adverse events (pooled odds ratio [OR] 1·49, 95% CI 1·22-1·81; I2=25%) and grade 2 and higher events (OR 1·75, 0·68-4·49; I2=0%), although the grade 2 and higher association was not statistically significant and events were rare (13 out of 6764 in the intervention group vs six out of 6782 in the control group). The IPDMA included 18 676 individuals from 15 countries (1453 [7·8%] from RCTs) and 79 (0·42%) had a baseline estimated creatinine clearance of less than 60 mL/min (increasing proportions with increasing age). Longitudinal analyses included 14 368 PrEP users and 349 (2·43%) individuals had a decline to less than 60 mL/min creatinine clearance, with higher risks associated with increasing age and baseline creatinine clearance of 60·00-89·99 mL/min (adjusted hazard ratio [aHR] 8·49, 95% CI 6·44-11·20) and less than 60 mL/min (aHR 20·83, 12·83-33·82). Interpretation: RCTs suggest that risks of kidney-related adverse events among tenofovir disoproxil fumarate-based oral PrEP users are increased but generally mild and small. Our global PrEP user analysis found varying risks by age and baseline creatinine clearance. Kidney function screening and monitoring might focus on older individuals, those with baseline creatinine clearance of less than 90 mL/min, and those with kidney-related comorbidities. Less frequent or optional screening among younger individuals without kidney-related comorbidities may reduce barriers to PrEP implementation and use.engElsevierKidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant datainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePrEPKidneyTenofovirHIVinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/52917/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALKidney function_Valdilea_Veloso_etal_INI_2022.pdfKidney function_Valdilea_Veloso_etal_INI_2022.pdfapplication/pdf804233https://www.arca.fiocruz.br/bitstream/icict/52917/2/Kidney%20function_Valdilea_Veloso_etal_INI_2022.pdf1d72959aadca3a11ed7b8fda83cf384aMD52icict/529172022-05-25 21:39:57.164oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-05-26T00:39:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data
title	Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data
spellingShingle	Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data Schaefer, Robin PrEP Kidney Tenofovir HIV
title_short	Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data
title_full	Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data
title_fullStr	Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data
title_full_unstemmed	Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data
title_sort	Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data
author	Schaefer, Robin
author_facet	Schaefer, Robin Leite, Pedro Henrique Amparo da Costa Silva, Ronaldo Karim, Quarraisha Abdool Akolo, Christopher Cáceres, Carlos F. Dourado, Inês Green, Kimberly Hettema, Anita Hoornenborg, Elske Jana, Smarajit Kerschberger, Bernhard Mahler, Hally Matse, Sindy McManus, Hamish Molina, Jean-Michel Reza-Paul, Sushena Azwa, Iskandar Shahmanesh, Maryam Taylor, Doug Vega-Ramirez, Hamid Veloso, Valdiléa G. Baggaley, Rachel Dalal, Shona
author_role	author
author2	Leite, Pedro Henrique Amparo da Costa Silva, Ronaldo Karim, Quarraisha Abdool Akolo, Christopher Cáceres, Carlos F. Dourado, Inês Green, Kimberly Hettema, Anita Hoornenborg, Elske Jana, Smarajit Kerschberger, Bernhard Mahler, Hally Matse, Sindy McManus, Hamish Molina, Jean-Michel Reza-Paul, Sushena Azwa, Iskandar Shahmanesh, Maryam Taylor, Doug Vega-Ramirez, Hamid Veloso, Valdiléa G. Baggaley, Rachel Dalal, Shona
author2_role	author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Schaefer, Robin Leite, Pedro Henrique Amparo da Costa Silva, Ronaldo Karim, Quarraisha Abdool Akolo, Christopher Cáceres, Carlos F. Dourado, Inês Green, Kimberly Hettema, Anita Hoornenborg, Elske Jana, Smarajit Kerschberger, Bernhard Mahler, Hally Matse, Sindy McManus, Hamish Molina, Jean-Michel Reza-Paul, Sushena Azwa, Iskandar Shahmanesh, Maryam Taylor, Doug Vega-Ramirez, Hamid Veloso, Valdiléa G. Baggaley, Rachel Dalal, Shona
dc.subject.en.pt_BR.fl_str_mv	PrEP Kidney Tenofovir HIV
topic	PrEP Kidney Tenofovir HIV
description	Unitaid, Bill & Melinda Gates Foundation, WHO.
publishDate	2022
dc.date.accessioned.fl_str_mv	2022-05-26T00:39:57Z
dc.date.available.fl_str_mv	2022-05-26T00:39:57Z
dc.date.issued.fl_str_mv	2022
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	SCHAEFER, Robin et al. Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data. The lancet. HIV, v. 9, n. 4, p. e242-e253, 2022
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/52917
dc.identifier.issn.pt_BR.fl_str_mv	2405-4704
dc.identifier.doi.none.fl_str_mv	10.1016/S2352-3018(22)00004-2
identifier_str_mv	SCHAEFER, Robin et al. Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data. The lancet. HIV, v. 9, n. 4, p. e242-e253, 2022 2405-4704 10.1016/S2352-3018(22)00004-2
url	https://www.arca.fiocruz.br/handle/icict/52917
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/52917/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/52917/2/Kidney%20function_Valdilea_Veloso_etal_INI_2022.pdf
bitstream.checksum.fl_str_mv	586c046dcfeef936e32f0323bb9a47c0 1d72959aadca3a11ed7b8fda83cf384a
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1798324662604660736

Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data

Registros relacionados