Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence?

Detalhes bibliográficos
Autor(a) principal: Rios, Fernanda Ferreira
Data de Publicação: 2016
Outros Autores: Freitas, Luiz Antonio Rodrigues de, Codes, Liana, Santos Junior, Genario Oliveira, Schinoni, Maria Isabel, Paraná, Raymundo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/17926
Resumo: Federal University of Bahia. School of Medical Sciences. Salvador, BA, Brazil
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spelling Rios, Fernanda FerreiraFreitas, Luiz Antonio Rodrigues deCodes, LianaSantos Junior, Genario OliveiraSchinoni, Maria IsabelParaná, Raymundo2017-03-03T18:07:33Z2017-03-03T18:07:33Z2016RIOS, F. F. et al. Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence? Annals of Hepatology, v. 15, n. 6, p. 932-938, 2016.1665-2681https://www.arca.fiocruz.br/handle/icict/1792610.5604/16652681.1222113engDesconhecidaFibrose portal não cirróticaEsclerose hepatoportalVenopatia portal obliteranteFígado.Hepatotoxicidade HerbalifeNon-cirrhotic portal fibrosisHepatoportal sclerosisObliterative portal venopathyLiverHerbalife hepatotoxicity Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Bahia. School of Medical Sciences. Salvador, BA, BrazilFederal University of Bahia. School of Medical Sciences. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. LPBI. Department of Pathology. Salvador, BA, BrasilFederal University of Bahia. Prof. Edgard Santos University Hospital. Salvador, BA, BrasilFederal University of Bahia. Prof. Edgard Santos University Hospital. Salvador, BA, BrasilFederal University of Bahia. School of Medical Sciences. Salvador, BA, Brazil / Federal University of Bahia. Institute of Science and Health. Salvador, BA, BrasilFederal University of Bahia. School of Medical Sciences. Salvador, BA, Brazil / Federal University of Bahia. Prof. Edgard Santos University Hospital. Salvador, BA, Brasil Introduction and aim. Non-cirrhotic idiopathic portal hypertension (NCIPH), also known as hepatoportal sclerosis (HPS) is a disease of uncertain etiology. However, various pathophysiological mechanisms has been postulated, including chronic or recurrent infections and exposure to drugs or toxins. In this context, it appears to be of multifactorial etiology or resulting from a portal vascular endothelium aggression. It is important to consider whether the use of dietary supplements and herbs can trigger or contribute to the occurance of HPS. We report a possible association of HPS with the consumption of herbals and / or dietary supplements.Material and methods. We describe two cases of HPS in patients without known etiology causes associated with this disease. Results. Both patients were females who were diagnosed with HPS following the consumption of Herbalife® products and putative anorexigenic agents in the herbal infusions. Image-based analysis and the assessment of the histopathological alterations found in the livers confirmed the diagnosis. The histopatological analysis of liver samples from both patients showed portal tracts enlarged by fibrosis with disappearance or reduction in the diameter of the portal vein branches. In many portal tracts, portal veins branches were replaced by aberrant thin-walled fendiforme vessels. The bile ducts and branches of the hepatic artery show normal aspects. Conclusion. After the exclusion of other etiologic factors and a comprehensive analysis of clinical history, consumption of Herbalife® products and anorexigenic agents was pointed-out as a puttative predisposing factor for the development of the disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17926/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRios FF Hepatoportal sclerosis....pdfRios FF Hepatoportal sclerosis....pdfapplication/pdf243988https://www.arca.fiocruz.br/bitstream/icict/17926/2/Rios%20FF%20Hepatoportal%20sclerosis....pdf351d033c7e51018231f25402307a98efMD52TEXTRios FF Hepatoportal sclerosis....pdf.txtRios FF Hepatoportal sclerosis....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv  Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence?
title  Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence?
spellingShingle  Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence?
Rios, Fernanda Ferreira
Fibrose portal não cirrótica
Esclerose hepatoportal
Venopatia portal obliterante
Fígado.
Hepatotoxicidade Herbalife
Non-cirrhotic portal fibrosis
Hepatoportal sclerosis
Obliterative portal venopathy
Liver
Herbalife hepatotoxicity
title_short  Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence?
title_full  Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence?
title_fullStr  Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence?
title_full_unstemmed  Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence?
title_sort  Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence?
author Rios, Fernanda Ferreira
author_facet Rios, Fernanda Ferreira
Freitas, Luiz Antonio Rodrigues de
Codes, Liana
Santos Junior, Genario Oliveira
Schinoni, Maria Isabel
Paraná, Raymundo
author_role author
author2 Freitas, Luiz Antonio Rodrigues de
Codes, Liana
Santos Junior, Genario Oliveira
Schinoni, Maria Isabel
Paraná, Raymundo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rios, Fernanda Ferreira
Freitas, Luiz Antonio Rodrigues de
Codes, Liana
Santos Junior, Genario Oliveira
Schinoni, Maria Isabel
Paraná, Raymundo
dc.subject.other.pt_BR.fl_str_mv Fibrose portal não cirrótica
Esclerose hepatoportal
Venopatia portal obliterante
Fígado.
Hepatotoxicidade Herbalife
topic Fibrose portal não cirrótica
Esclerose hepatoportal
Venopatia portal obliterante
Fígado.
Hepatotoxicidade Herbalife
Non-cirrhotic portal fibrosis
Hepatoportal sclerosis
Obliterative portal venopathy
Liver
Herbalife hepatotoxicity
dc.subject.en.pt_BR.fl_str_mv Non-cirrhotic portal fibrosis
Hepatoportal sclerosis
Obliterative portal venopathy
Liver
Herbalife hepatotoxicity
description Federal University of Bahia. School of Medical Sciences. Salvador, BA, Brazil
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-03-03T18:07:33Z
dc.date.available.fl_str_mv 2017-03-03T18:07:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RIOS, F. F. et al. Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence? Annals of Hepatology, v. 15, n. 6, p. 932-938, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17926
dc.identifier.issn.pt_BR.fl_str_mv 1665-2681
dc.identifier.doi.none.fl_str_mv 10.5604/16652681.1222113
identifier_str_mv RIOS, F. F. et al. Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence? Annals of Hepatology, v. 15, n. 6, p. 932-938, 2016.
1665-2681
10.5604/16652681.1222113
url https://www.arca.fiocruz.br/handle/icict/17926
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Desconhecida
publisher.none.fl_str_mv Desconhecida
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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