Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013

Detalhes bibliográficos
Autor(a) principal: Mendoza, Yaxelis
Data de Publicação: 2014
Outros Autores: Bello, Gonzalo, Mewa, Juan Castillo, Martinez, Alexander A., González, Claudia, Garcia-Morales, Claudia, Avila-Rios, Santiago, Reyes-Terán, Gustavo, Pascale, Juan M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9979
Resumo: Gorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama / Acharya Nagarjuna University. Department of Biotechnology. Guntur City, Andhra Pradesh, India / University of Panama.Department of Genetics and Molecular Biology. Panama City, Panama / INDICASAT-AIP, 219, City of Knowledge, Clayton, Panama City, Panama.
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spelling Mendoza, YaxelisBello, GonzaloMewa, Juan CastilloMartinez, Alexander A.González, ClaudiaGarcia-Morales, ClaudiaAvila-Rios, SantiagoReyes-Terán, GustavoPascale, Juan M.2015-04-14T12:38:12Z2015-04-14T12:38:12Z2014MENDOZA, Yaxelis et al. Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013. Plos One, v.9, n.1, 2014.https://www.arca.fiocruz.br/handle/icict/9979engPlos oNEMolecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama / Acharya Nagarjuna University. Department of Biotechnology. Guntur City, Andhra Pradesh, India / University of Panama.Department of Genetics and Molecular Biology. Panama City, Panama / INDICASAT-AIP, 219, City of Knowledge, Clayton, Panama City, Panama.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Gorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama.Gorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama / Acharya Nagarjuna University. Department of Biotechnology. Guntur City, Andhra Pradesh, India / INDICASAT-AIP, 219, City of Knowledge, Clayton, Panama City, Panama.Gorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama.Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico.Gorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama / Acharya Nagarjuna University. Department of Biotechnology. Guntur City, Andhra Pradesh, India / University of Panama.Department of Genetics and Molecular Biology. Panama City, Panama / INDICASAT-AIP, 219, City of Knowledge, Clayton, Panama City, Panama.Phylogenetic studies have suggested that the HIV-1 epidemic in the Americas is mainly dominated by HIV subtype B. However, countries of South America and the Caribbean have recently reported changes in their circulating HIV-1 genetic profiles. The aim of this study was to characterize the molecular profile of the HIV-1 epidemic in Panama by the analysis of 655 polymerase gene (pol) sequences that were obtained from HIV-infected Panamanians diagnosed between 1987 and 2013. Blood samples were collected from recently infected, antiretroviral drug-naı¨ve and treatment-experienced subjects since mid-2007 to 2013. Viral RNA from plasma was extracted and sequences of HIV protease and reverse transcriptase genes were obtained. Bootscanning and phylogenetic methods were used for HIV subtyping and to trace the putative origin of non-B subtype strains. Our results showed that HIV-1 infections in Panama are dominated by subtype B (98.9%). The remaining 1.1% is represented by a diverse collection of recombinant variants including: three URFs_BC, one CRF20_BG, and one CRF28/29_BF, in addition to one subtype F1 and one subtype C, none of which were previously reported in Panama. The non-B subtype variants detected in Panama were probably introduced from Brazil (subtype F1 and CRF28/ 29_BF), Cuba (CRF20_BG), Dominican Republic (URFs_BC) and India (subtype C). Panama is the geographical vertex that connects the North with South America and the Caribbean through trade and cultural relations, which may explain the observed introductions of non-B subtype HIV-1 variants from both the Caribbean and South America into this Central American country.Hiv-1Molecular EpidemiologyHIV InfectionsInfecciones por VIHEpidemiología MolecularEpidemiologia MolecularHIV-1Infecções por HIVinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/9979/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALgonzalo_belloetal1_IOC_2014.pdfapplication/pdf1618144https://www.arca.fiocruz.br/bitstream/icict/9979/2/gonzalo_belloetal1_IOC_2014.pdfe6562d2199c1d320fb34a941c71af191MD52TEXTgonzalo_belloetal1_IOC_2014.pdf.txtgonzalo_belloetal1_IOC_2014.pdf.txtExtracted texttext/plain48078https://www.arca.fiocruz.br/bitstream/icict/9979/3/gonzalo_belloetal1_IOC_2014.pdf.txte978404315c2e11ce7c8d27fddb40700MD53icict/99792022-06-24 13:08:45.098oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:45Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013
title Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013
spellingShingle Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013
Mendoza, Yaxelis
Hiv-1
Molecular Epidemiology
HIV Infections
Infecciones por VIH
Epidemiología Molecular
Epidemiologia Molecular
HIV-1
Infecções por HIV
title_short Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013
title_full Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013
title_fullStr Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013
title_full_unstemmed Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013
title_sort Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013
author Mendoza, Yaxelis
author_facet Mendoza, Yaxelis
Bello, Gonzalo
Mewa, Juan Castillo
Martinez, Alexander A.
González, Claudia
Garcia-Morales, Claudia
Avila-Rios, Santiago
Reyes-Terán, Gustavo
Pascale, Juan M.
author_role author
author2 Bello, Gonzalo
Mewa, Juan Castillo
Martinez, Alexander A.
González, Claudia
Garcia-Morales, Claudia
Avila-Rios, Santiago
Reyes-Terán, Gustavo
Pascale, Juan M.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mendoza, Yaxelis
Bello, Gonzalo
Mewa, Juan Castillo
Martinez, Alexander A.
González, Claudia
Garcia-Morales, Claudia
Avila-Rios, Santiago
Reyes-Terán, Gustavo
Pascale, Juan M.
dc.subject.en.pt_BR.fl_str_mv Hiv-1
Molecular Epidemiology
HIV Infections
topic Hiv-1
Molecular Epidemiology
HIV Infections
Infecciones por VIH
Epidemiología Molecular
Epidemiologia Molecular
HIV-1
Infecções por HIV
dc.subject.es.pt_BR.fl_str_mv Infecciones por VIH
Epidemiología Molecular
dc.subject.decs.pt_BR.fl_str_mv Epidemiologia Molecular
HIV-1
Infecções por HIV
description Gorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama / Acharya Nagarjuna University. Department of Biotechnology. Guntur City, Andhra Pradesh, India / University of Panama.Department of Genetics and Molecular Biology. Panama City, Panama / INDICASAT-AIP, 219, City of Knowledge, Clayton, Panama City, Panama.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-04-14T12:38:12Z
dc.date.available.fl_str_mv 2015-04-14T12:38:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENDOZA, Yaxelis et al. Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013. Plos One, v.9, n.1, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9979
identifier_str_mv MENDOZA, Yaxelis et al. Molecular Epidemiology of HIV-1 in Panama: Origin of Non-B Subtypes in Samples Collected from 2007 to 2013. Plos One, v.9, n.1, 2014.
url https://www.arca.fiocruz.br/handle/icict/9979
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Plos oNE
publisher.none.fl_str_mv Plos oNE
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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