Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region

Detalhes bibliográficos
Autor(a) principal: Cabello, Marina
Data de Publicação: 2014
Outros Autores: Mendoza, Yaxelis, Bello, Gonzalo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9972
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil
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spelling Cabello, MarinaMendoza, YaxelisBello, Gonzalo2015-04-14T12:38:11Z2015-04-14T12:38:11Z2014CABELLO, Mariza et al. Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region. Plos One, v.9, n.8, 2014.https://www.arca.fiocruz.br/handle/icict/9972engPlos OneHIV-1Infecções por HIVCaribeHiv-1HIV InfectionsCaribbeanHIV-1Infecciones por VIHCaribeSpatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Regioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, BrasilGorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama / Acharya Nagarjuna University. Department of Biotechnology. Guntur City, Andhra Pradesh, India / University of Panama.Department of Genetics and Molecular Biology. Panama City, Panama / INDICASAT-AIP, 219, City of Knowledge, Clayton, Panama City, Panama.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, BrasilThe Human immunodeficiency virus type-1 (HIV-1) epidemic in the Caribbean region is mostly driven by subtype B; but information about the pattern of viral spread in this geographic region is scarce and different studies point to quite divergent models of viral dissemination. In this study, we reconstructed the spatiotemporal and population dynamics of the HIV-1 subtype B epidemic in the Caribbean. A total of 1,806 HIV-1 subtype B pol sequences collected from 17 different Caribbean islands between 1996 and 2011 were analyzed together with sequences from the United States (n = 525) and France (n = 340) included as control. Maximum Likelihood phylogenetic analyses revealed that HIV-1 subtype B infections in the Caribbean are driven by dissemination of the pandemic clade (BPANDEMIC) responsible for most subtype B infections across the world, and older non-pandemic lineages (BCAR) characteristics of the Caribbean region. The non-pandemic BCAR strains account for .40% of HIV-1 infections in most Caribbean islands; with exception of Cuba and Puerto Rico. Bayesian phylogeographic analyses indicate that BCAR strains probably arose in the island of Hispaniola (Haiti/Dominican Republic) around the middle 1960s and were later disseminated to Trinidad and Tobago and to Jamaica between the late 1960s and the early 1970s. In the following years, the BCAR strains were also disseminated from Hispaniola and Trinidad and Tobago to other Lesser Antilles islands at multiple times. The BCAR clades circulating in Hispaniola, Jamaica and Trinidad and Tobago appear to have experienced an initial phase of exponential growth, with mean estimated growth rates of 0.35–0.45 year21, followed by a more recent stabilization since the middle 1990s. These results demonstrate that non-pandemic subtype B lineages have been widely disseminated through the Caribbean since the late 1960s and account for an important fraction of current HIV-1 infections in the region.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/9972/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALmarina_cabelloetal_IOC_2014.pdfapplication/pdf3389067https://www.arca.fiocruz.br/bitstream/icict/9972/2/marina_cabelloetal_IOC_2014.pdf4bdc88894fbb0141ba0ebedb225d085eMD52TEXTmarina_cabelloetal_IOC_2014.pdf.txtmarina_cabelloetal_IOC_2014.pdf.txtExtracted texttext/plain54108https://www.arca.fiocruz.br/bitstream/icict/9972/3/marina_cabelloetal_IOC_2014.pdf.txt4469f978e48251b65cb4a1e7986c6693MD53icict/99722022-06-24 12:17:42.407oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:17:42Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region
title Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region
spellingShingle Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region
Cabello, Marina
HIV-1
Infecções por HIV
Caribe
Hiv-1
HIV Infections
Caribbean
HIV-1
Infecciones por VIH
Caribe
title_short Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region
title_full Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region
title_fullStr Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region
title_full_unstemmed Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region
title_sort Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region
author Cabello, Marina
author_facet Cabello, Marina
Mendoza, Yaxelis
Bello, Gonzalo
author_role author
author2 Mendoza, Yaxelis
Bello, Gonzalo
author2_role author
author
dc.contributor.author.fl_str_mv Cabello, Marina
Mendoza, Yaxelis
Bello, Gonzalo
dc.subject.other.pt_BR.fl_str_mv HIV-1
Infecções por HIV
Caribe
topic HIV-1
Infecções por HIV
Caribe
Hiv-1
HIV Infections
Caribbean
HIV-1
Infecciones por VIH
Caribe
dc.subject.en.pt_BR.fl_str_mv Hiv-1
HIV Infections
Caribbean
dc.subject.es.pt_BR.fl_str_mv HIV-1
Infecciones por VIH
Caribe
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-04-14T12:38:11Z
dc.date.available.fl_str_mv 2015-04-14T12:38:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CABELLO, Mariza et al. Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region. Plos One, v.9, n.8, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9972
identifier_str_mv CABELLO, Mariza et al. Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region. Plos One, v.9, n.8, 2014.
url https://www.arca.fiocruz.br/handle/icict/9972
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Plos One
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