Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis

Detalhes bibliográficos
Autor(a) principal: Boulanger, Catherine
Data de Publicação: 2020
Outros Autores: Rolla, Valeria, Al-Shaer, Mohammad H., Peloquin, Charles
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40473
Resumo: University of Miami Miller School of Medicine. Miami, FL, USA.
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spelling Boulanger, CatherineRolla, ValeriaAl-Shaer, Mohammad H.Peloquin, Charles2020-03-24T14:12:02Z2020-03-24T14:12:02Z2020BOULANGER, Catherine et al. Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis. International Journal of Antimicrobial Agents, v. 55, n. 2, p. 1-19, 2020.0924-8579https://www.arca.fiocruz.br/handle/icict/4047310.1016/j.ijantimicag.2019.10.021engElsevierHIVLopinavirPharmacokineticsRifampicinRitonavirTuberculosisEvaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Miami Miller School of Medicine. Miami, FL, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of Florida. College of Pharmacy, and Emerging Pathogens Institute. Gainesville, FL, USA.University of Florida. College of Pharmacy, and Emerging Pathogens Institute. Gainesville, FL, USA.Rifampicin induces the metabolism of many drugs. To overcome the reduction in serum concentrations of lopinavir/ritonavir (LPV/r) when used in combination with rifampicin, 800/200 mg or 400/400 mg doses are used. This study evaluated super-boosted LPV/r (400/400 mg) in HIV/TB co-infected patients for adequate concentrations as well as short-term safety, tolerability and clinical response to therapy. This was an open-label, non-randomised pharmacokinetic (PK) study in HIV/TB patients. The primary objective was to determine the PK profile of super-boosted LPV/r when given with a rifampicin-based TB regimen. Secondary objectives were short-term safety, tolerability and clinical response. Primary endpoints were a lopinavir trough concentration (Cmin) >1.0 µg/mL and a rifampicin maximum concentration (Cmax) of 8-24 µg/mL. Secondary PK endpoints were a rifampicin area under the concentration-time curve from 0-24 h (AUC0-24) of 44-70 µg·h/mL, a lopinavir Cmax of 6-14 µg/mL and a lopinavir AUC0-12 of 56-130 µg·h/mL. Eleven patients (10 male, age 25-43 years) were enrolled. Two patients were discontinued due to non-compliance. A lopinavir Cmin of >1.0 µg/mL was achieved in a least one of the PK samplings in all nine subjects who completed treatment. All patients met lopinavir Cmax and AUC0-12 targets. Five patients achieved the primary endpoint of rifampicin Cmax (≥8 µg/mL) in at least one of the PK samplings, and five achieved the minimum rifampicin AUC0-24 (≥44 µg·h/mL). One grade 3 adverse event was reported. Super-boosted LPV/r was safe and effective in HIV/TB patients. 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dc.title.pt_BR.fl_str_mv Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis
title Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis
spellingShingle Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis
Boulanger, Catherine
HIV
Lopinavir
Pharmacokinetics
Rifampicin
Ritonavir
Tuberculosis
title_short Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis
title_full Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis
title_fullStr Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis
title_full_unstemmed Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis
title_sort Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis
author Boulanger, Catherine
author_facet Boulanger, Catherine
Rolla, Valeria
Al-Shaer, Mohammad H.
Peloquin, Charles
author_role author
author2 Rolla, Valeria
Al-Shaer, Mohammad H.
Peloquin, Charles
author2_role author
author
author
dc.contributor.author.fl_str_mv Boulanger, Catherine
Rolla, Valeria
Al-Shaer, Mohammad H.
Peloquin, Charles
dc.subject.other.pt_BR.fl_str_mv HIV
Lopinavir
Pharmacokinetics
Rifampicin
Ritonavir
Tuberculosis
topic HIV
Lopinavir
Pharmacokinetics
Rifampicin
Ritonavir
Tuberculosis
description University of Miami Miller School of Medicine. Miami, FL, USA.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-03-24T14:12:02Z
dc.date.available.fl_str_mv 2020-03-24T14:12:02Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BOULANGER, Catherine et al. Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis. International Journal of Antimicrobial Agents, v. 55, n. 2, p. 1-19, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40473
dc.identifier.issn.pt_BR.fl_str_mv 0924-8579
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.ijantimicag.2019.10.021
identifier_str_mv BOULANGER, Catherine et al. Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis. International Journal of Antimicrobial Agents, v. 55, n. 2, p. 1-19, 2020.
0924-8579
10.1016/j.ijantimicag.2019.10.021
url https://www.arca.fiocruz.br/handle/icict/40473
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/40473/1/license.txt
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