Administration of lopinavir/ritonavir association during rat pregnancy: maternal and fetal effects
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://www.irog.net/download/?magazine=111 http://repositorio.unifesp.br/handle/11600/43296 |
Resumo: | Purpose: To evaluate the effects of the association of lopinavir and ritonavir administered during the whole period of rat pregnancy. Methods: 62 Wistar rats of the EPM-1 variant weighing about 200 g were randomly divided into five groups: two controls (Ctr1 = stress control, n = 10; and Ctr2 = drug vehicle control, n = 10) and three experimental ones which were treated with an oral solution of lopinavir/ritonavir (Exp1 = 12.8/3.2 mg/kg b.w., n = 14; Exp2 = 38.4/9.6 mg/kg b.w., n = 14; Exp3 = 115.2/28.8 mg/kg b.w., n = 14) from 'day 0' up to the 20th day of pregnancy. Maternal body weight was recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day), upon laparotomy and hysterotomy, the rats were anesthetized and the amount of implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were recorded. The collected fetuses and placentae were weighed and the concepts were examined under a stereoscope microscope for external malformations. Results: An apparent dose-unrelated lethal effect of the antiviral association on the pregnant rats was observed; notwithstanding, the body weight gain of the surviving rats had no changes, independent of the considered group. It was noted that the quantitative and qualitative intrauterine content of living term rats was indistinguishable from that of the controls. Conclusion: There was some degree of deleterious effects of the administration of the lopinavir/ritonavir association on pregnant rats; such effects eventually led to maternal death. However, neither the surviving rats showed toxicity nor did their concepts present any detectable change which could be related to the drug association. |
id |
UFSP_6f07b069f5ea1abe97e7cfd8a7214c6f |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/43296 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Administration of lopinavir/ritonavir association during rat pregnancy: maternal and fetal effectsRatPregnancyLopinavirRitonavirPurpose: To evaluate the effects of the association of lopinavir and ritonavir administered during the whole period of rat pregnancy. Methods: 62 Wistar rats of the EPM-1 variant weighing about 200 g were randomly divided into five groups: two controls (Ctr1 = stress control, n = 10; and Ctr2 = drug vehicle control, n = 10) and three experimental ones which were treated with an oral solution of lopinavir/ritonavir (Exp1 = 12.8/3.2 mg/kg b.w., n = 14; Exp2 = 38.4/9.6 mg/kg b.w., n = 14; Exp3 = 115.2/28.8 mg/kg b.w., n = 14) from 'day 0' up to the 20th day of pregnancy. Maternal body weight was recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day), upon laparotomy and hysterotomy, the rats were anesthetized and the amount of implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were recorded. The collected fetuses and placentae were weighed and the concepts were examined under a stereoscope microscope for external malformations. Results: An apparent dose-unrelated lethal effect of the antiviral association on the pregnant rats was observed; notwithstanding, the body weight gain of the surviving rats had no changes, independent of the considered group. It was noted that the quantitative and qualitative intrauterine content of living term rats was indistinguishable from that of the controls. Conclusion: There was some degree of deleterious effects of the administration of the lopinavir/ritonavir association on pregnant rats; such effects eventually led to maternal death. However, neither the surviving rats showed toxicity nor did their concepts present any detectable change which could be related to the drug association.Univ Fed Sao Paulo, Dept Obstet & Gynecol, Sch Med UNIFESP EPM, Sao Paulo, BrazilUniv Sao Paulo, Fac Med FMUSP, Sao Paulo, BrazilJose do Rosario Vellano Univ, Sch Med, Dept Internal Med, Alfenas, MG, BrazilSao Paulo Univ USP, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, BrazilABC Med Fdn FUABC, Dept Obstet & Pediat, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Obstet & Gynecol, Sch Med UNIFESP EPM, Sao Paulo, BrazilWeb of ScienceI R O G Canada, IncUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Jose do Rosario Vellano UnivABC Med Fdn FUABCKulay Júnior, Luiz [UNIFESP]Hagemann, Cristiane Cadore de Farias [UNIFESP]Nakamura, Mary Uchiyama [UNIFESP]Simoes, Ricardo Santos [UNIFESP]Carvalho, Adelino Moreira de [UNIFESP]Oliveira-Filho, Ricardo Martins [UNIFESP]Espiridião, Silvia [UNIFESP]2018-06-15T16:52:39Z2018-06-15T16:52:39Z2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion151-154http://www.irog.net/download/?magazine=111Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 40, n. 1, p. 151-154, 2013.0390-6663http://repositorio.unifesp.br/handle/11600/43296WOS:000315752800040engClinical And Experimental Obstetrics & Gynecologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T15:58:35Zoai:repositorio.unifesp.br/:11600/43296Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T15:58:35Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Administration of lopinavir/ritonavir association during rat pregnancy: maternal and fetal effects |
title |
Administration of lopinavir/ritonavir association during rat pregnancy: maternal and fetal effects |
spellingShingle |
Administration of lopinavir/ritonavir association during rat pregnancy: maternal and fetal effects Kulay Júnior, Luiz [UNIFESP] Rat Pregnancy Lopinavir Ritonavir |
title_short |
Administration of lopinavir/ritonavir association during rat pregnancy: maternal and fetal effects |
title_full |
Administration of lopinavir/ritonavir association during rat pregnancy: maternal and fetal effects |
title_fullStr |
Administration of lopinavir/ritonavir association during rat pregnancy: maternal and fetal effects |
title_full_unstemmed |
Administration of lopinavir/ritonavir association during rat pregnancy: maternal and fetal effects |
title_sort |
Administration of lopinavir/ritonavir association during rat pregnancy: maternal and fetal effects |
author |
Kulay Júnior, Luiz [UNIFESP] |
author_facet |
Kulay Júnior, Luiz [UNIFESP] Hagemann, Cristiane Cadore de Farias [UNIFESP] Nakamura, Mary Uchiyama [UNIFESP] Simoes, Ricardo Santos [UNIFESP] Carvalho, Adelino Moreira de [UNIFESP] Oliveira-Filho, Ricardo Martins [UNIFESP] Espiridião, Silvia [UNIFESP] |
author_role |
author |
author2 |
Hagemann, Cristiane Cadore de Farias [UNIFESP] Nakamura, Mary Uchiyama [UNIFESP] Simoes, Ricardo Santos [UNIFESP] Carvalho, Adelino Moreira de [UNIFESP] Oliveira-Filho, Ricardo Martins [UNIFESP] Espiridião, Silvia [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) Jose do Rosario Vellano Univ ABC Med Fdn FUABC |
dc.contributor.author.fl_str_mv |
Kulay Júnior, Luiz [UNIFESP] Hagemann, Cristiane Cadore de Farias [UNIFESP] Nakamura, Mary Uchiyama [UNIFESP] Simoes, Ricardo Santos [UNIFESP] Carvalho, Adelino Moreira de [UNIFESP] Oliveira-Filho, Ricardo Martins [UNIFESP] Espiridião, Silvia [UNIFESP] |
dc.subject.por.fl_str_mv |
Rat Pregnancy Lopinavir Ritonavir |
topic |
Rat Pregnancy Lopinavir Ritonavir |
description |
Purpose: To evaluate the effects of the association of lopinavir and ritonavir administered during the whole period of rat pregnancy. Methods: 62 Wistar rats of the EPM-1 variant weighing about 200 g were randomly divided into five groups: two controls (Ctr1 = stress control, n = 10; and Ctr2 = drug vehicle control, n = 10) and three experimental ones which were treated with an oral solution of lopinavir/ritonavir (Exp1 = 12.8/3.2 mg/kg b.w., n = 14; Exp2 = 38.4/9.6 mg/kg b.w., n = 14; Exp3 = 115.2/28.8 mg/kg b.w., n = 14) from 'day 0' up to the 20th day of pregnancy. Maternal body weight was recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day), upon laparotomy and hysterotomy, the rats were anesthetized and the amount of implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were recorded. The collected fetuses and placentae were weighed and the concepts were examined under a stereoscope microscope for external malformations. Results: An apparent dose-unrelated lethal effect of the antiviral association on the pregnant rats was observed; notwithstanding, the body weight gain of the surviving rats had no changes, independent of the considered group. It was noted that the quantitative and qualitative intrauterine content of living term rats was indistinguishable from that of the controls. Conclusion: There was some degree of deleterious effects of the administration of the lopinavir/ritonavir association on pregnant rats; such effects eventually led to maternal death. However, neither the surviving rats showed toxicity nor did their concepts present any detectable change which could be related to the drug association. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01 2018-06-15T16:52:39Z 2018-06-15T16:52:39Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.irog.net/download/?magazine=111 Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 40, n. 1, p. 151-154, 2013. 0390-6663 http://repositorio.unifesp.br/handle/11600/43296 WOS:000315752800040 |
url |
http://www.irog.net/download/?magazine=111 http://repositorio.unifesp.br/handle/11600/43296 |
identifier_str_mv |
Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 40, n. 1, p. 151-154, 2013. 0390-6663 WOS:000315752800040 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical And Experimental Obstetrics & Gynecology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
151-154 |
dc.publisher.none.fl_str_mv |
I R O G Canada, Inc |
publisher.none.fl_str_mv |
I R O G Canada, Inc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268392812576768 |