Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18334 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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Pinto, Luzia Maria de OliveiraGandini, MarianaFreitas, Laís PicininiSiqueira, Marilda Agudo Mendonça Teixeira deMarinho, Cíntia FerreiraSetúbal, SérgioKubelka, Claire FernandesCruz, Oswaldo GonçalvesOliveira, Solange Artimos de2017-04-09T16:49:41Z2017-04-09T16:49:41Z2012PINTO, Luzia Maria de Oliveira; et al. Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis. Mem Inst Oswaldo Cruz, v.107, n.1, p.48-56, Feb.2012 .0074-0276https://www.arca.fiocruz.br/handle/icict/1833410.1590/S0074-027620120001000071678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.DengueQuimiocinasParvovirus B19 Humano dengueparvovirus B19chemokinesIL-1RaProfile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e de Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, Rj, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Programa de Comuptação Científica. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, Rj, Brasil.Dengue virus (DENV) and parvovirus B19 (B19V) infections are acute exanthematic febrile illnesses that are not easily differentiated on clinical grounds and affect the paediatric population. Patients with these acute exanthematic diseases were studied. Fever was more frequent in DENV than in B19V-infected patients. Arthritis/arthralgias with DENV infection were shown to be significantly more frequent in adults than in children. The circulating levels of interleukin (IL)-1 receptor antagonist (Ra), CXCL10/inducible protein-10 (IP-10), CCL4/macrophage inflammatory protein-1 beta and CCL2/monocyte chemotactic protein-1 (MCP-1) were determined by multiplex immunoassay in serum samples obtained from B19V (37) and DENV-infected (36) patients and from healthy individuals (7). Forward stepwise logistic regression analysis revealed that circulating CXCL10/IP-10 tends to be associated with DENV infection and that IL-1Ra was significantly associated with DENV infection. Similar analysis showed that circulating CCL2/MCP-1 tends to be associated with B19V infection. In dengue fever, increased circulating IL-1Ra may exert antipyretic actions in an effort to counteract the already increased concentrations of IL-1β, while CXCL10/IP-10 was confirmed as a strong pro-inflammatory marker. Recruitment of monocytes/macrophages and upregulation of the humoral immune response by CCL2/MCP-1 by B19V may be involved in the persistence of the infection. Children with B19V or DENV infections had levels of these cytokines similar to those of adult patientsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18334/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmariana_gandini_etal_IOC_2012,pdf.pdfmariana_gandini_etal_IOC_2012,pdf.pdfapplication/pdf465077https://www.arca.fiocruz.br/bitstream/icict/18334/2/mariana_gandini_etal_IOC_2012%2cpdf.pdf204d53603bc9a00c7e27c59d86d9e222MD52TEXTmariana_gandini_etal_IOC_2012,pdf.pdf.txtmariana_gandini_etal_IOC_2012,pdf.pdf.txtExtracted texttext/plain45730https://www.arca.fiocruz.br/bitstream/icict/18334/3/mariana_gandini_etal_IOC_2012%2cpdf.pdf.txt7588b6df9f6d8dc35769423583f33d80MD53icict/183342022-03-23 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| dc.title.pt_BR.fl_str_mv |
Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis |
| title |
Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis |
| spellingShingle |
Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis Pinto, Luzia Maria de Oliveira Dengue Quimiocinas Parvovirus B19 Humano dengue parvovirus B19 chemokines IL-1Ra |
| title_short |
Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis |
| title_full |
Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis |
| title_fullStr |
Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis |
| title_full_unstemmed |
Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis |
| title_sort |
Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis |
| author |
Pinto, Luzia Maria de Oliveira |
| author_facet |
Pinto, Luzia Maria de Oliveira Gandini, Mariana Freitas, Laís Picinini Siqueira, Marilda Agudo Mendonça Teixeira de Marinho, Cíntia Ferreira Setúbal, Sérgio Kubelka, Claire Fernandes Cruz, Oswaldo Gonçalves Oliveira, Solange Artimos de |
| author_role |
author |
| author2 |
Gandini, Mariana Freitas, Laís Picinini Siqueira, Marilda Agudo Mendonça Teixeira de Marinho, Cíntia Ferreira Setúbal, Sérgio Kubelka, Claire Fernandes Cruz, Oswaldo Gonçalves Oliveira, Solange Artimos de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pinto, Luzia Maria de Oliveira Gandini, Mariana Freitas, Laís Picinini Siqueira, Marilda Agudo Mendonça Teixeira de Marinho, Cíntia Ferreira Setúbal, Sérgio Kubelka, Claire Fernandes Cruz, Oswaldo Gonçalves Oliveira, Solange Artimos de |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Quimiocinas Parvovirus B19 Humano |
| topic |
Dengue Quimiocinas Parvovirus B19 Humano dengue parvovirus B19 chemokines IL-1Ra |
| dc.subject.en.pt_BR.fl_str_mv |
dengue parvovirus B19 chemokines IL-1Ra |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2012 |
| dc.date.issued.fl_str_mv |
2012 |
| dc.date.accessioned.fl_str_mv |
2017-04-09T16:49:41Z |
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2017-04-09T16:49:41Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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PINTO, Luzia Maria de Oliveira; et al. Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis. Mem Inst Oswaldo Cruz, v.107, n.1, p.48-56, Feb.2012 . |
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https://www.arca.fiocruz.br/handle/icict/18334 |
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0074-0276 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02762012000100007 |
| dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
| identifier_str_mv |
PINTO, Luzia Maria de Oliveira; et al. Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis. Mem Inst Oswaldo Cruz, v.107, n.1, p.48-56, Feb.2012 . 0074-0276 10.1590/S0074-02762012000100007 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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