Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15353 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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Pinto, Luzia Maria de OliveiraMarinho, Cíntia FerreiraPovoa, Tiago FajardoAzeredo, Elzinandes Leal deSouza, Luiza Assed deBarbosa, Luiza Damian RibeiroCastro, Ana Rita C. MottaAlves, Ada M. B.Ávila, Carlos André LinsSouza, Luiz José deCunha, Rivaldo Venâncio daDamasco, Paulo VieiraPaes, Marciano VianaKubelka, Claire Fernandes2016-08-23T17:54:11Z2016-08-23T17:54:11Z2012PINTO, Luzia Maria de Oliveira; et al. Regulation of Inflammatory Chemokine Receptors on Blood T Cells Associated to the Circulating Versus Liver Chemokines in Dengue Fever. Plos One, v.7, n.7, e38527, 14p, July 2012.1932-6203https://www.arca.fiocruz.br/handle/icict/1535310.1371/journal.pone.0038527engPublic Library of ScienceDengueReceptores de QuimiocinasFígadoCélulas TDengue feverChemokine receptorsBlood T cellsLiver chemokinesRegulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue feverinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Centro Regional de Referência em Dengue. Campos dos Goytacazes, RJ, Brasil.Centro Regional de Referência em Dengue. Campos dos Goytacazes, RJ, Brasil.Universidade Federal do Mato Grosso do Sul. Setor Hemonúcleo. MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil.Centro Regional de Referência em Dengue. Campos dos Goytacazes, RJ, Brasil.Universidade Federal do Mato Grosso do Sul. Setor Hemonúcleo. MS, Brasil.Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Little is known about the role of chemokines/chemokines receptors on T cells in natural DENV infection. Patients from DENV-2 and -3- outbreaks were studied prospectively during the acute or convalescent phases. Expression of chemokine receptor and activation markers on lymphocyte subpopulations were determined by flow cytometry analysis, plasma chemokine ligands concentrations were measured by ELISA and quantification of CCL5/RANTES(+) cells in liver tissues from fatal dengue cases was performed by immunochemistry. In the acute DENV-infection, T-helper/T-cytotoxic type-1 cell (Th1/Tc1)-related CCR5 is significantly higher expressed on both CD4 and CD8 T cells. The Th1-related CXCR3 is up-regulated among CD4 T cells and Tc2-related CCR4 is up-regulated among CD8 T cells. In the convalescent phase, all chemokine receptor or chemokine ligand expression tends to reestablish control healthy levels. Increased CCL2/MCP-1 and CCL4/MIP-1β but decreased CCL5/RANTES levels were observed in DENV-patients during acute infection. Moreover, we showed an increased CD107a expression on CCR5 or CXCR3-expressing T cells and higher expression of CD29, CD44(HIGH) and CD127(LOW) markers on CCR4-expressing CD8 T cells in DENV-patients when compared to controls. Finally, liver from dengue fatal patients showed increased number of cells expressing CCL5/RANTES in three out of four cases compared to three death from a non-dengue patient. In conclusion, both Th1-related CCR5 and CXCR3 among CD4 T cells have a potential ability to exert cytotoxicity function. Moreover, Tc1-related CCR5 and Tc2-related CCR4 among CD8 T cells have a potential ability to exert effector function and migration based on cell markers evaluated. The CCR5 expression would be promoting an enhanced T cell recruitment into liver, a hypothesis that is corroborated by the CCL5/RANTES increase detected in hepatic tissue from dengue fatal cases. The balance between protective and pathogenic immune response mediated by chemokines during dengue fever will be discussed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15353/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALluzia_pinto_etal_IOC_2012_pdf.pdfluzia_pinto_etal_IOC_2012_pdf.pdfapplication/pdf2540207https://www.arca.fiocruz.br/bitstream/icict/15353/2/luzia_pinto_etal_IOC_2012_pdf.pdfaf0db94f39a761c4b3ce0bdb94242401MD52TEXTluzia_pinto_etal_IOC_2012_pdf.pdf.txtluzia_pinto_etal_IOC_2012_pdf.pdf.txtExtracted texttext/plain67555https://www.arca.fiocruz.br/bitstream/icict/15353/3/luzia_pinto_etal_IOC_2012_pdf.pdf.txt7de7f6cdab9a7c78bf431d41f5e3f0efMD53icict/153532018-04-02 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| dc.title.pt_BR.fl_str_mv |
Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever |
| title |
Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever |
| spellingShingle |
Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever Pinto, Luzia Maria de Oliveira Dengue Receptores de Quimiocinas Fígado Células T Dengue fever Chemokine receptors Blood T cells Liver chemokines |
| title_short |
Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever |
| title_full |
Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever |
| title_fullStr |
Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever |
| title_full_unstemmed |
Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever |
| title_sort |
Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever |
| author |
Pinto, Luzia Maria de Oliveira |
| author_facet |
Pinto, Luzia Maria de Oliveira Marinho, Cíntia Ferreira Povoa, Tiago Fajardo Azeredo, Elzinandes Leal de Souza, Luiza Assed de Barbosa, Luiza Damian Ribeiro Castro, Ana Rita C. Motta Alves, Ada M. B. Ávila, Carlos André Lins Souza, Luiz José de Cunha, Rivaldo Venâncio da Damasco, Paulo Vieira Paes, Marciano Viana Kubelka, Claire Fernandes |
| author_role |
author |
| author2 |
Marinho, Cíntia Ferreira Povoa, Tiago Fajardo Azeredo, Elzinandes Leal de Souza, Luiza Assed de Barbosa, Luiza Damian Ribeiro Castro, Ana Rita C. Motta Alves, Ada M. B. Ávila, Carlos André Lins Souza, Luiz José de Cunha, Rivaldo Venâncio da Damasco, Paulo Vieira Paes, Marciano Viana Kubelka, Claire Fernandes |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pinto, Luzia Maria de Oliveira Marinho, Cíntia Ferreira Povoa, Tiago Fajardo Azeredo, Elzinandes Leal de Souza, Luiza Assed de Barbosa, Luiza Damian Ribeiro Castro, Ana Rita C. Motta Alves, Ada M. B. Ávila, Carlos André Lins Souza, Luiz José de Cunha, Rivaldo Venâncio da Damasco, Paulo Vieira Paes, Marciano Viana Kubelka, Claire Fernandes |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Receptores de Quimiocinas Fígado Células T |
| topic |
Dengue Receptores de Quimiocinas Fígado Células T Dengue fever Chemokine receptors Blood T cells Liver chemokines |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue fever Chemokine receptors Blood T cells Liver chemokines |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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2012 |
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2012 |
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2016-08-23T17:54:11Z |
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2016-08-23T17:54:11Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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PINTO, Luzia Maria de Oliveira; et al. Regulation of Inflammatory Chemokine Receptors on Blood T Cells Associated to the Circulating Versus Liver Chemokines in Dengue Fever. Plos One, v.7, n.7, e38527, 14p, July 2012. |
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https://www.arca.fiocruz.br/handle/icict/15353 |
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1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0038527 |
| identifier_str_mv |
PINTO, Luzia Maria de Oliveira; et al. Regulation of Inflammatory Chemokine Receptors on Blood T Cells Associated to the Circulating Versus Liver Chemokines in Dengue Fever. Plos One, v.7, n.7, e38527, 14p, July 2012. 1932-6203 10.1371/journal.pone.0038527 |
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