Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase

Detalhes bibliográficos
Autor(a) principal: Gandara, Ana Caroline Paiva
Data de Publicação: 2017
Outros Autores: Torres, André, Bahia, Ana Cristina, Oliveira, Pedro L., Schama, Renata
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23455
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
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spelling Gandara, Ana Caroline PaivaTorres, AndréBahia, Ana CristinaOliveira, Pedro L.Schama, Renata2017-11-30T10:01:50Z2017-11-30T10:01:50Z2017GANDARA, Ana Caroline Paiva; et al. Evolutionary origin and function of NOX4- art, an arthropod specific NADPH oxidase. BMC Evolutionary Biology, v.17:92, 16p, 2017.1471-2148https://www.arca.fiocruz.br/handle/icict/2345510.1186/s12862-017-0940-0engBioMed CentralNADPH oxidaseProteínas de Fusão gag-oncArtrópodesEspécies Reativas de OxigênioFamília de genesPerda genéticaNADPH oxidaseGene lossGene familyArthropodsROSReactive oxygen speciesEvolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil.NADPH oxidases (NOX) are ROS producing enzymes that perform essential roles in cell physiology, including cell signaling and antimicrobial defense. This gene family is present in most eukaryotes, suggesting a common ancestor. To date, only a limited number of phylogenetic studies of metazoan NOXes have been performed, with few arthropod genes. In arthropods, only NOX5 and DUOX genes have been found and a gene called NOXm was found in mosquitoes but its origin and function has not been examined. In this study, we analyzed the evolution of this gene family in arthropods. A thorough search of genomes and transcriptomes was performed enabling us to browse most branches of arthropod phylogeny.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23455/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALrenata2_schama_etal_IOC_2017.pdfrenata2_schama_etal_IOC_2017.pdfapplication/pdf2000466https://www.arca.fiocruz.br/bitstream/icict/23455/2/renata2_schama_etal_IOC_2017.pdf00603fb93ccd3bbc2b9fc43abbd78ce5MD52TEXTrenata2_schama_etal_IOC_2017.pdf.txtrenata2_schama_etal_IOC_2017.pdf.txtExtracted texttext/plain76951https://www.arca.fiocruz.br/bitstream/icict/23455/3/renata2_schama_etal_IOC_2017.pdf.txt5b0b70487458c970d66f7bc0bf365ea7MD53icict/234552018-08-15 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dc.title.pt_BR.fl_str_mv Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase
title Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase
spellingShingle Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase
Gandara, Ana Caroline Paiva
NADPH oxidase
Proteínas de Fusão gag-onc
Artrópodes
Espécies Reativas de Oxigênio
Família de genes
Perda genética
NADPH oxidase
Gene loss
Gene family
Arthropods
ROS
Reactive oxygen species
title_short Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase
title_full Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase
title_fullStr Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase
title_full_unstemmed Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase
title_sort Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase
author Gandara, Ana Caroline Paiva
author_facet Gandara, Ana Caroline Paiva
Torres, André
Bahia, Ana Cristina
Oliveira, Pedro L.
Schama, Renata
author_role author
author2 Torres, André
Bahia, Ana Cristina
Oliveira, Pedro L.
Schama, Renata
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gandara, Ana Caroline Paiva
Torres, André
Bahia, Ana Cristina
Oliveira, Pedro L.
Schama, Renata
dc.subject.other.pt_BR.fl_str_mv NADPH oxidase
Proteínas de Fusão gag-onc
Artrópodes
Espécies Reativas de Oxigênio
Família de genes
Perda genética
topic NADPH oxidase
Proteínas de Fusão gag-onc
Artrópodes
Espécies Reativas de Oxigênio
Família de genes
Perda genética
NADPH oxidase
Gene loss
Gene family
Arthropods
ROS
Reactive oxygen species
dc.subject.en.pt_BR.fl_str_mv NADPH oxidase
Gene loss
Gene family
Arthropods
ROS
Reactive oxygen species
description Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-11-30T10:01:50Z
dc.date.available.fl_str_mv 2017-11-30T10:01:50Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GANDARA, Ana Caroline Paiva; et al. Evolutionary origin and function of NOX4- art, an arthropod specific NADPH oxidase. BMC Evolutionary Biology, v.17:92, 16p, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23455
dc.identifier.issn.pt_BR.fl_str_mv 1471-2148
dc.identifier.doi.none.fl_str_mv 10.1186/s12862-017-0940-0
identifier_str_mv GANDARA, Ana Caroline Paiva; et al. Evolutionary origin and function of NOX4- art, an arthropod specific NADPH oxidase. BMC Evolutionary Biology, v.17:92, 16p, 2017.
1471-2148
10.1186/s12862-017-0940-0
url https://www.arca.fiocruz.br/handle/icict/23455
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/23455/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/23455/2/renata2_schama_etal_IOC_2017.pdf
https://www.arca.fiocruz.br/bitstream/icict/23455/3/renata2_schama_etal_IOC_2017.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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