Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil

Detalhes bibliográficos
Autor(a) principal: Fabri, Allison Araújo
Data de Publicação: 2020
Outros Autores: Rodrigues, Cintia Damasceno dos Santos, Santos, Carolina Cardoso dos, Chalhoub, Flávia Löwen Levy, Sampaio, Simone Alves, Faria, Nieli Rodrigues da Costa, Torres, Maria Celeste, Fonseca, Vagner, Brasil, Patricia, Calvet, Guilherme, Alcantara, Luiz Carlos Junior, Filippis, Ana Maria Bispo de, Giovanetti, Marta, Bruycker-Nogueira, Fernanda de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45814
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
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spelling Fabri, Allison AraújoRodrigues, Cintia Damasceno dos SantosSantos, Carolina Cardoso dosChalhoub, Flávia Löwen LevySampaio, Simone AlvesFaria, Nieli Rodrigues da CostaTorres, Maria CelesteFonseca, VagnerBrasil, PatriciaCalvet, GuilhermeAlcantara, Luiz Carlos JuniorFilippis, Ana Maria Bispo deGiovanetti, MartaBruycker-Nogueira, Fernanda de2021-01-25T21:12:27Z2021-01-25T21:12:27Z2020FABRI, Allison Araújo et al. Co-Circulation of Two Independent Clades and Persistence of CHIKV-ECSA Genotype during Epidemic Waves in Rio de Janeiro, Southeast Brazil. Pathogens, v. 9, n. 12, p. 1-12, 2020.2076-0817https://www.arca.fiocruz.br/handle/icict/4581410.3390/pathogens9120984engMDPICo-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.University of KwaZulu-Natal. College of Health Sciences. Nelson R Mandela School of Medicine. School of Laboratory Medicine and Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP). Durban, South Africa / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / Ministério da Saúde. Coordenação Geral dos Laboratórios de Saúde Pública/Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.The Chikungunya virus infection in Brazil has raised several concerns due to the rapid dissemination of the virus and its association with several clinical complications. Nevertheless, there is limited information about the genomic epidemiology of CHIKV circulating in Brazil from surveillance studies. Thus, to better understand its dispersion dynamics in Rio de Janeiro (RJ), one of the most affected states during the 2016-2019 epidemic waves, we generated 23 near-complete genomes of CHIKV isolates from two main cities located in the metropolitan mesoregion, obtained directly from clinical samples. Our phylogenetic reconstructions suggest the 2019-CHIKV-ECSA epidemic in RJ state was characterized by the co-circulation of multiple clade (clade A and B), highlighting that two independent introduction events of CHIKV-ECSA into RJ state have occurred between 2016-2019, both mediated from the northeastern region. Interestingly, we identified that the two-clade displaying eighteen characteristic amino acids changes among structural and non-structural proteins. Our findings reinforce that genomic data can provide information about virus genetic diversity and transmission dynamics, which might assist in the arbovirus epidemics establishing of an effective surveillance framework.BrazilECSA genotypeChikungunya virusCo-circulationPersistenceRio de Janeiroinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/45814/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALCo-circulation_Patricia_Brasil_etal_INI_2020.pdfCo-circulation_Patricia_Brasil_etal_INI_2020.pdfapplication/pdf641864https://www.arca.fiocruz.br/bitstream/icict/45814/2/Co-circulation_Patricia_Brasil_etal_INI_2020.pdf420ee0b77de39e686a779be2ba7ea170MD52TEXTCo-circulation_Patricia_Brasil_etal_INI_2020.pdf.txtCo-circulation_Patricia_Brasil_etal_INI_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil
title Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil
spellingShingle Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil
Fabri, Allison Araújo
Brazil
ECSA genotype
Chikungunya virus
Co-circulation
Persistence
Rio de Janeiro
title_short Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil
title_full Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil
title_fullStr Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil
title_full_unstemmed Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil
title_sort Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil
author Fabri, Allison Araújo
author_facet Fabri, Allison Araújo
Rodrigues, Cintia Damasceno dos Santos
Santos, Carolina Cardoso dos
Chalhoub, Flávia Löwen Levy
Sampaio, Simone Alves
Faria, Nieli Rodrigues da Costa
Torres, Maria Celeste
Fonseca, Vagner
Brasil, Patricia
Calvet, Guilherme
Alcantara, Luiz Carlos Junior
Filippis, Ana Maria Bispo de
Giovanetti, Marta
Bruycker-Nogueira, Fernanda de
author_role author
author2 Rodrigues, Cintia Damasceno dos Santos
Santos, Carolina Cardoso dos
Chalhoub, Flávia Löwen Levy
Sampaio, Simone Alves
Faria, Nieli Rodrigues da Costa
Torres, Maria Celeste
Fonseca, Vagner
Brasil, Patricia
Calvet, Guilherme
Alcantara, Luiz Carlos Junior
Filippis, Ana Maria Bispo de
Giovanetti, Marta
Bruycker-Nogueira, Fernanda de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fabri, Allison Araújo
Rodrigues, Cintia Damasceno dos Santos
Santos, Carolina Cardoso dos
Chalhoub, Flávia Löwen Levy
Sampaio, Simone Alves
Faria, Nieli Rodrigues da Costa
Torres, Maria Celeste
Fonseca, Vagner
Brasil, Patricia
Calvet, Guilherme
Alcantara, Luiz Carlos Junior
Filippis, Ana Maria Bispo de
Giovanetti, Marta
Bruycker-Nogueira, Fernanda de
dc.subject.en.pt_BR.fl_str_mv Brazil
ECSA genotype
Chikungunya virus
Co-circulation
Persistence
Rio de Janeiro
topic Brazil
ECSA genotype
Chikungunya virus
Co-circulation
Persistence
Rio de Janeiro
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-01-25T21:12:27Z
dc.date.available.fl_str_mv 2021-01-25T21:12:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv FABRI, Allison Araújo et al. Co-Circulation of Two Independent Clades and Persistence of CHIKV-ECSA Genotype during Epidemic Waves in Rio de Janeiro, Southeast Brazil. Pathogens, v. 9, n. 12, p. 1-12, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45814
dc.identifier.issn.pt_BR.fl_str_mv 2076-0817
dc.identifier.doi.none.fl_str_mv 10.3390/pathogens9120984
identifier_str_mv FABRI, Allison Araújo et al. Co-Circulation of Two Independent Clades and Persistence of CHIKV-ECSA Genotype during Epidemic Waves in Rio de Janeiro, Southeast Brazil. Pathogens, v. 9, n. 12, p. 1-12, 2020.
2076-0817
10.3390/pathogens9120984
url https://www.arca.fiocruz.br/handle/icict/45814
dc.language.iso.fl_str_mv eng
language eng
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