Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45814 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. |
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Fabri, Allison AraújoRodrigues, Cintia Damasceno dos SantosSantos, Carolina Cardoso dosChalhoub, Flávia Löwen LevySampaio, Simone AlvesFaria, Nieli Rodrigues da CostaTorres, Maria CelesteFonseca, VagnerBrasil, PatriciaCalvet, GuilhermeAlcantara, Luiz Carlos JuniorFilippis, Ana Maria Bispo deGiovanetti, MartaBruycker-Nogueira, Fernanda de2021-01-25T21:12:27Z2021-01-25T21:12:27Z2020FABRI, Allison Araújo et al. Co-Circulation of Two Independent Clades and Persistence of CHIKV-ECSA Genotype during Epidemic Waves in Rio de Janeiro, Southeast Brazil. Pathogens, v. 9, n. 12, p. 1-12, 2020.2076-0817https://www.arca.fiocruz.br/handle/icict/4581410.3390/pathogens9120984engMDPICo-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.University of KwaZulu-Natal. College of Health Sciences. Nelson R Mandela School of Medicine. School of Laboratory Medicine and Medical Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP). Durban, South Africa / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / Ministério da Saúde. Coordenação Geral dos Laboratórios de Saúde Pública/Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.The Chikungunya virus infection in Brazil has raised several concerns due to the rapid dissemination of the virus and its association with several clinical complications. Nevertheless, there is limited information about the genomic epidemiology of CHIKV circulating in Brazil from surveillance studies. Thus, to better understand its dispersion dynamics in Rio de Janeiro (RJ), one of the most affected states during the 2016-2019 epidemic waves, we generated 23 near-complete genomes of CHIKV isolates from two main cities located in the metropolitan mesoregion, obtained directly from clinical samples. Our phylogenetic reconstructions suggest the 2019-CHIKV-ECSA epidemic in RJ state was characterized by the co-circulation of multiple clade (clade A and B), highlighting that two independent introduction events of CHIKV-ECSA into RJ state have occurred between 2016-2019, both mediated from the northeastern region. Interestingly, we identified that the two-clade displaying eighteen characteristic amino acids changes among structural and non-structural proteins. Our findings reinforce that genomic data can provide information about virus genetic diversity and transmission dynamics, which might assist in the arbovirus epidemics establishing of an effective surveillance framework.BrazilECSA genotypeChikungunya virusCo-circulationPersistenceRio de Janeiroinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/45814/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALCo-circulation_Patricia_Brasil_etal_INI_2020.pdfCo-circulation_Patricia_Brasil_etal_INI_2020.pdfapplication/pdf641864https://www.arca.fiocruz.br/bitstream/icict/45814/2/Co-circulation_Patricia_Brasil_etal_INI_2020.pdf420ee0b77de39e686a779be2ba7ea170MD52TEXTCo-circulation_Patricia_Brasil_etal_INI_2020.pdf.txtCo-circulation_Patricia_Brasil_etal_INI_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil |
| title |
Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil |
| spellingShingle |
Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil Fabri, Allison Araújo Brazil ECSA genotype Chikungunya virus Co-circulation Persistence Rio de Janeiro |
| title_short |
Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil |
| title_full |
Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil |
| title_fullStr |
Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil |
| title_full_unstemmed |
Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil |
| title_sort |
Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil |
| author |
Fabri, Allison Araújo |
| author_facet |
Fabri, Allison Araújo Rodrigues, Cintia Damasceno dos Santos Santos, Carolina Cardoso dos Chalhoub, Flávia Löwen Levy Sampaio, Simone Alves Faria, Nieli Rodrigues da Costa Torres, Maria Celeste Fonseca, Vagner Brasil, Patricia Calvet, Guilherme Alcantara, Luiz Carlos Junior Filippis, Ana Maria Bispo de Giovanetti, Marta Bruycker-Nogueira, Fernanda de |
| author_role |
author |
| author2 |
Rodrigues, Cintia Damasceno dos Santos Santos, Carolina Cardoso dos Chalhoub, Flávia Löwen Levy Sampaio, Simone Alves Faria, Nieli Rodrigues da Costa Torres, Maria Celeste Fonseca, Vagner Brasil, Patricia Calvet, Guilherme Alcantara, Luiz Carlos Junior Filippis, Ana Maria Bispo de Giovanetti, Marta Bruycker-Nogueira, Fernanda de |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fabri, Allison Araújo Rodrigues, Cintia Damasceno dos Santos Santos, Carolina Cardoso dos Chalhoub, Flávia Löwen Levy Sampaio, Simone Alves Faria, Nieli Rodrigues da Costa Torres, Maria Celeste Fonseca, Vagner Brasil, Patricia Calvet, Guilherme Alcantara, Luiz Carlos Junior Filippis, Ana Maria Bispo de Giovanetti, Marta Bruycker-Nogueira, Fernanda de |
| dc.subject.en.pt_BR.fl_str_mv |
Brazil ECSA genotype Chikungunya virus Co-circulation Persistence Rio de Janeiro |
| topic |
Brazil ECSA genotype Chikungunya virus Co-circulation Persistence Rio de Janeiro |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020 |
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2021-01-25T21:12:27Z |
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2021-01-25T21:12:27Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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FABRI, Allison Araújo et al. Co-Circulation of Two Independent Clades and Persistence of CHIKV-ECSA Genotype during Epidemic Waves in Rio de Janeiro, Southeast Brazil. Pathogens, v. 9, n. 12, p. 1-12, 2020. |
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https://www.arca.fiocruz.br/handle/icict/45814 |
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2076-0817 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/pathogens9120984 |
| identifier_str_mv |
FABRI, Allison Araújo et al. Co-Circulation of Two Independent Clades and Persistence of CHIKV-ECSA Genotype during Epidemic Waves in Rio de Janeiro, Southeast Brazil. Pathogens, v. 9, n. 12, p. 1-12, 2020. 2076-0817 10.3390/pathogens9120984 |
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