Drug resistance of M. Tuberculosis isolated from patients with HIV infection seen at an AIDS Reference Center in São Paulo, Brazil

Detalhes bibliográficos
Autor(a) principal: Pinto, Walkyria P
Data de Publicação: 1996
Outros Autores: Hadad, David J, Palhares, M. Cecília A, Ferrazoli, Lucilaine, Telles, M. Alice S., Ueki, Sueli Y.M., Santos, Márcia T. F., Placco, Ana L. N., Sauaia, Naim, Palac, Moisés
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/29332
Resumo: M. tuberculosis-positive cultures were obtained from 228 patients seen in our service and drug sensitivity assays were carried out from January 1992 to December 1994. A survey of the medical records of these patients showed resistance to one or more drugs in 47 (20.6%), 25 of whom (10.9%), who reported previous treatment, were considered to have acquired resistance. Among the antecedents investigated, only previous treatment and alcoholism were the factors independently associated with the occurrence of resistance. The survival of patients with resistant strains was lower than that of patients attacked by non-resistant M. tuberculosis. We conclude that in the present series M. tuberculosis resistance to tuberculostatic agents was predominantly of the acquired type.
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spelling Drug resistance of M. Tuberculosis isolated from patients with HIV infection seen at an AIDS Reference Center in São Paulo, Brazil Resistência a drogas de M. tuberculosis isolados de pacientes com infecção pelo HIV atendidos no Centro de Referência e Treinamento DST/AIDS, São Paulo, Brasil TuberculosisTuberculosis treatmentAIDSMultidrug resistanceDrug resistanceHIV infection M. tuberculosis-positive cultures were obtained from 228 patients seen in our service and drug sensitivity assays were carried out from January 1992 to December 1994. A survey of the medical records of these patients showed resistance to one or more drugs in 47 (20.6%), 25 of whom (10.9%), who reported previous treatment, were considered to have acquired resistance. Among the antecedents investigated, only previous treatment and alcoholism were the factors independently associated with the occurrence of resistance. The survival of patients with resistant strains was lower than that of patients attacked by non-resistant M. tuberculosis. We conclude that in the present series M. tuberculosis resistance to tuberculostatic agents was predominantly of the acquired type. No período de janeiro de 1992 a dezembro de 1994, foram obtidas culturas positivas para M. tuberculosis e foram realizados testes de sensibilidade a drogas em 228 pacientes atendidos no Centro de Referência DST/AIDS-SP. Através da revisão dos prontuários de todos os casos verificamos resistência a uma ou mais drogas em 47(20.6%), dos quais 25(10.9 %), que relatavam tratamento pregresso, foram considerados como portadores de resistência adquirida. Dos antecedentes investigados, somente os fatores tratamento prévio e alcoolismo foram independentemente associados à ocorrência de resistência. A sobrevivência dos pacientes portadores de cepas resistentes foi menor que a dos pacientes acometidos por M. tuberculosis não resistentes. Concluimos que nesta casuística a resistência do M. tuberculosis aos tuberculostáticos foi predominantemente do tipo adquirida. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1996-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/29332Revista do Instituto de Medicina Tropical de São Paulo; Vol. 38 No. 1 (1996); 15-21 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 38 Núm. 1 (1996); 15-21 Revista do Instituto de Medicina Tropical de São Paulo; v. 38 n. 1 (1996); 15-21 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/29332/31189Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessPinto, Walkyria PHadad, David JPalhares, M. Cecília AFerrazoli, LucilaineTelles, M. Alice S.Ueki, Sueli Y.M.Santos, Márcia T. F.Placco, Ana L. N.Sauaia, NaimPalac, Moisés2012-07-02T01:42:59Zoai:revistas.usp.br:article/29332Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:04.837157Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Drug resistance of M. Tuberculosis isolated from patients with HIV infection seen at an AIDS Reference Center in São Paulo, Brazil
Resistência a drogas de M. tuberculosis isolados de pacientes com infecção pelo HIV atendidos no Centro de Referência e Treinamento DST/AIDS, São Paulo, Brasil
title Drug resistance of M. Tuberculosis isolated from patients with HIV infection seen at an AIDS Reference Center in São Paulo, Brazil
spellingShingle Drug resistance of M. Tuberculosis isolated from patients with HIV infection seen at an AIDS Reference Center in São Paulo, Brazil
Pinto, Walkyria P
Tuberculosis
Tuberculosis treatment
AIDS
Multidrug resistance
Drug resistance
HIV infection
title_short Drug resistance of M. Tuberculosis isolated from patients with HIV infection seen at an AIDS Reference Center in São Paulo, Brazil
title_full Drug resistance of M. Tuberculosis isolated from patients with HIV infection seen at an AIDS Reference Center in São Paulo, Brazil
title_fullStr Drug resistance of M. Tuberculosis isolated from patients with HIV infection seen at an AIDS Reference Center in São Paulo, Brazil
title_full_unstemmed Drug resistance of M. Tuberculosis isolated from patients with HIV infection seen at an AIDS Reference Center in São Paulo, Brazil
title_sort Drug resistance of M. Tuberculosis isolated from patients with HIV infection seen at an AIDS Reference Center in São Paulo, Brazil
author Pinto, Walkyria P
author_facet Pinto, Walkyria P
Hadad, David J
Palhares, M. Cecília A
Ferrazoli, Lucilaine
Telles, M. Alice S.
Ueki, Sueli Y.M.
Santos, Márcia T. F.
Placco, Ana L. N.
Sauaia, Naim
Palac, Moisés
author_role author
author2 Hadad, David J
Palhares, M. Cecília A
Ferrazoli, Lucilaine
Telles, M. Alice S.
Ueki, Sueli Y.M.
Santos, Márcia T. F.
Placco, Ana L. N.
Sauaia, Naim
Palac, Moisés
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pinto, Walkyria P
Hadad, David J
Palhares, M. Cecília A
Ferrazoli, Lucilaine
Telles, M. Alice S.
Ueki, Sueli Y.M.
Santos, Márcia T. F.
Placco, Ana L. N.
Sauaia, Naim
Palac, Moisés
dc.subject.por.fl_str_mv Tuberculosis
Tuberculosis treatment
AIDS
Multidrug resistance
Drug resistance
HIV infection
topic Tuberculosis
Tuberculosis treatment
AIDS
Multidrug resistance
Drug resistance
HIV infection
description M. tuberculosis-positive cultures were obtained from 228 patients seen in our service and drug sensitivity assays were carried out from January 1992 to December 1994. A survey of the medical records of these patients showed resistance to one or more drugs in 47 (20.6%), 25 of whom (10.9%), who reported previous treatment, were considered to have acquired resistance. Among the antecedents investigated, only previous treatment and alcoholism were the factors independently associated with the occurrence of resistance. The survival of patients with resistant strains was lower than that of patients attacked by non-resistant M. tuberculosis. We conclude that in the present series M. tuberculosis resistance to tuberculostatic agents was predominantly of the acquired type.
publishDate 1996
dc.date.none.fl_str_mv 1996-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/29332
url https://www.revistas.usp.br/rimtsp/article/view/29332
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/29332/31189
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 38 No. 1 (1996); 15-21
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 38 Núm. 1 (1996); 15-21
Revista do Instituto de Medicina Tropical de São Paulo; v. 38 n. 1 (1996); 15-21
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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