Analysis of serious non-AIDS events among HIV-infected adults at Latin Amercian sites
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37504 |
Resumo: | 2020-11-29 |
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Belloso, W. H.Orellana, L. C.Grinsztejn, BeatrizMadero, J. S.La Rosa, A.Veloso, V. G.Sanchez, J.Moreira, R. I.Crabtree-Ramirez, B.Garcia Messina, O.Lasala, M. B.Peinado, J.Losso, M. H.2019-11-29T13:35:57Z2019-11-29T13:35:57Z2010BELLOSO, W. H. et al. Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites, v. 11, p. 554-564, 2010.1464-2662https://www.arca.fiocruz.br/handle/icict/3750410.1111/j.1468-1293.2010.00824.x1468-1293engWileyAnalysis of serious non-AIDS events among HIV-infected adults at Latin Amercian sitesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-11-29Hospital Italiano. Buenos Aires, Argentina / Cooperación Internacional Córdoba-América Latina (CICAL). Córdoba. Argentina.Universidad de Buenos Aires. Instituto de Cálculo. Buenos Aires, Argentina.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico DF, Mexico.Investigaciones Médicas en Salud (INMENSA). Lima, Peru.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Investigaciones Médicas en Salud (INMENSA). Lima, Peru.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico DF, Mexico.Hospital Parmenio Piñero. Buenos Aires, Argentina.Hospital de Clínicas José de San Martín. Buenos Aires, Argentina.Investigaciones Médicas en Salud (INMENSA). Lima, Peru.Hospital J. M. Ramos Mejía. Buenos Aires, Argentina / Cooperación Internacional Córdoba-América Latina (CICAL). Córdoba. Argentina.Objective: Acquired immune deficiency appears to be associated with serious non-AIDS (SNA)-defining conditions such as cardiovascular disease, liver and renal insufficiency and non-AIDS-related malignancies. We analysed the incidence of, and factors associated with, several SNA events in the LATINA retrospective cohort. Materials and methods: Cases of SNA events were recorded among cohort patients. Three controls were selected for each case from cohort members at risk. Conditional logistic models were fitted to estimate the effect of traditional risk factors as well as HIV-associated factors on non-AIDS-defining conditions. Results: Among 6007 patients in follow-up, 130 had an SNA event (0.86 events/100 person-years of follow-up) and were defined as cases (40 with cardiovascular events, 54 with serious liver failure, 35 with non-AIDS-defining malignancies and two with renal insufficiency). Risk factors such as diabetes,hepatitis B and C virus coinfections and alcohol abuse showed an association with events, asexpected. The last recorded CD4 T-cell count prior to index date (P50.0056, with an average difference of more than 100 cells/mL) and area under the CD4 cell curve in the year previous to indexdate (P50.0081) were significantly lower in cases than in controls. CD4 cell count at index date was significantly associated with the outcome after adjusting for risk factors. Conclusions: The incidence and type of SNA events found in this Latin American cohort are similar to those reported in other regions. We found a significant association between immune deficiency and therisk of SNA events, even in patients under antiretroviral treatment.AIDSCardiovascular diseaseCD4 cell lymphocyte countCohort studiesLiver diseasesNeoplasmsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37504/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Belloso_W_etal_INI_2010.pdfve_Belloso_W_etal_INI_2010.pdfapplication/pdf119703https://www.arca.fiocruz.br/bitstream/icict/37504/2/ve_Belloso_W_etal_INI_2010.pdf228035b08c74285b041f03e503e639d9MD52TEXTve_Belloso_W_etal_INI_2010.pdf.txtve_Belloso_W_etal_INI_2010.pdf.txtExtracted texttext/plain50774https://www.arca.fiocruz.br/bitstream/icict/37504/3/ve_Belloso_W_etal_INI_2010.pdf.txt0f74b22b3abe0934e9ba4f88aeb8bdbeMD53icict/375042023-06-15 16:17:46.758oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-15T19:17:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Analysis of serious non-AIDS events among HIV-infected adults at Latin Amercian sites |
| title |
Analysis of serious non-AIDS events among HIV-infected adults at Latin Amercian sites |
| spellingShingle |
Analysis of serious non-AIDS events among HIV-infected adults at Latin Amercian sites Belloso, W. H. AIDS Cardiovascular disease CD4 cell lymphocyte count Cohort studies Liver diseases Neoplasms |
| title_short |
Analysis of serious non-AIDS events among HIV-infected adults at Latin Amercian sites |
| title_full |
Analysis of serious non-AIDS events among HIV-infected adults at Latin Amercian sites |
| title_fullStr |
Analysis of serious non-AIDS events among HIV-infected adults at Latin Amercian sites |
| title_full_unstemmed |
Analysis of serious non-AIDS events among HIV-infected adults at Latin Amercian sites |
| title_sort |
Analysis of serious non-AIDS events among HIV-infected adults at Latin Amercian sites |
| author |
Belloso, W. H. |
| author_facet |
Belloso, W. H. Orellana, L. C. Grinsztejn, Beatriz Madero, J. S. La Rosa, A. Veloso, V. G. Sanchez, J. Moreira, R. I. Crabtree-Ramirez, B. Garcia Messina, O. Lasala, M. B. Peinado, J. Losso, M. H. |
| author_role |
author |
| author2 |
Orellana, L. C. Grinsztejn, Beatriz Madero, J. S. La Rosa, A. Veloso, V. G. Sanchez, J. Moreira, R. I. Crabtree-Ramirez, B. Garcia Messina, O. Lasala, M. B. Peinado, J. Losso, M. H. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Belloso, W. H. Orellana, L. C. Grinsztejn, Beatriz Madero, J. S. La Rosa, A. Veloso, V. G. Sanchez, J. Moreira, R. I. Crabtree-Ramirez, B. Garcia Messina, O. Lasala, M. B. Peinado, J. Losso, M. H. |
| dc.subject.en.pt_BR.fl_str_mv |
AIDS Cardiovascular disease CD4 cell lymphocyte count Cohort studies Liver diseases Neoplasms |
| topic |
AIDS Cardiovascular disease CD4 cell lymphocyte count Cohort studies Liver diseases Neoplasms |
| description |
2020-11-29 |
| publishDate |
2010 |
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2010 |
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2019-11-29T13:35:57Z |
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2019-11-29T13:35:57Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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BELLOSO, W. H. et al. Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites, v. 11, p. 554-564, 2010. |
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https://www.arca.fiocruz.br/handle/icict/37504 |
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1464-2662 |
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10.1111/j.1468-1293.2010.00824.x |
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1468-1293 |
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BELLOSO, W. H. et al. Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites, v. 11, p. 554-564, 2010. 1464-2662 10.1111/j.1468-1293.2010.00824.x 1468-1293 |
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Wiley |
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Wiley |
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