A novel classification system for evolutionary aging theories

Detalhes bibliográficos
Autor(a) principal: Trindade, Lucas S.
Data de Publicação: 2013
Outros Autores: Aigaki, Toshiro, Peixoto, Alexandre A., Balduíno, Alex, Cruz, Ivana B. Mânica, Heddle, Jonathan G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11558
Resumo: Advanced Science Institute. Heddle Initiative Research Unit. Wako, Saitama, Japan / Nagasaki University. Graduate School of Biomedical Sciences. Department of Investigative Pathology. Nagasaki, Japan / Tokyo Metropolitan University. Department of Biological Sciences. Hachioji, Tokyo, Japanh.
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spelling Trindade, Lucas S.Aigaki, ToshiroPeixoto, Alexandre A.Balduíno, AlexCruz, Ivana B. MânicaHeddle, Jonathan G.2015-08-19T13:49:32Z2015-08-19T13:49:32Z2013TRINDADE, Lucas S.; et al. A novel classification system for evolutionary aging theories. Frontiers in Genetics, v.4, Art.25, 8p, March 2013.1664-802https://www.arca.fiocruz.br/handle/icict/1155810.3389/fgene.2013.00025engFrontiers Media S.AA novel classification system for evolutionary aging theoriesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAdvanced Science Institute. Heddle Initiative Research Unit. Wako, Saitama, Japan / Nagasaki University. Graduate School of Biomedical Sciences. Department of Investigative Pathology. Nagasaki, Japan / Tokyo Metropolitan University. Department of Biological Sciences. Hachioji, Tokyo, Japanh.Tokyo Metropolitan University, Department of Biological Sciences. Hachioji, Tokyo, Japan,Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil.Universidade Veiga de Almeida. Centro de Pesquisa em Desenvolvimento e Tecnologia. Rio de Janeiro, RJ, Brasil.Universidade Federal de Santa Maria. Centro de Ciências da Saúde. Departamento de Morfologia. Santa Maria, RS, Brasil.Advanced Science Institute. Heddle Initiative Research Unit. Wako, Saitama, JapanTheories of lifespan evolution are a source of confusion amongst aging researchers. After a century of aging research the dispute over whether the aging process is active or passive persists and a comprehensive and universally accepted theoretical model remains elusive. Evolutionary aging theories primarily dispute whether the aging process is exclusively adapted to favor the kin or exclusively non-adapted to favor the individual. Interestingly, contradictory data and theories supporting both exclusively programmed and exclusively non-programmed theories continue to grow. However, this is a false dichotomy; natural selection favors traits resulting in efficient reproduction whether they benefit the individual or the kin. Thus, to understand the evolution of aging, first we must understand the environment-dependent balance between the advantages and disadvantages of extended lifespan in the process of spreading genes. As described by distinct theories, different niches and environmental conditions confer on extended lifespan a range of fitness values varying from highly beneficial to highly detrimental. Here, we considered the range of fitness values for extended lifespan and develop a fitness-based framework for categorizing existing theories. We show that all theories can be classified into four basic types: secondary (beneficial), maladaptive (neutral), assisted death (detrimental), and senemorphic aging (varying between beneficial to detrimental). We anticipate that this classification system will assist with understanding and interpreting aging/death by providing a way of considering theories as members of one of these classes rather than consideration of their individual details.SenemorphismCaloric restrictionLongevityAltruismSenescenceEvolutionEnvelhecimentoAltruísmoLongevidadeRestrição Calóricainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11558/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALalexandre_peixoto_etal_IOC_2013.pdfapplication/pdf1041270https://www.arca.fiocruz.br/bitstream/icict/11558/2/alexandre_peixoto_etal_IOC_2013.pdfbd31c8d919246ec768ac96057fa5bd1fMD52TEXTalexandre_peixoto_etal_IOC_2013.pdf.txtalexandre_peixoto_etal_IOC_2013.pdf.txtExtracted texttext/plain53824https://www.arca.fiocruz.br/bitstream/icict/11558/3/alexandre_peixoto_etal_IOC_2013.pdf.txt8e8fa1090ca1116a414b04659ea5e3aaMD53icict/115582022-06-24 13:12:33.052oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:12:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv A novel classification system for evolutionary aging theories
title A novel classification system for evolutionary aging theories
spellingShingle A novel classification system for evolutionary aging theories
Trindade, Lucas S.
Senemorphism
Caloric restriction
Longevity
Altruism
Senescence
Evolution
Envelhecimento
Altruísmo
Longevidade
Restrição Calórica
title_short A novel classification system for evolutionary aging theories
title_full A novel classification system for evolutionary aging theories
title_fullStr A novel classification system for evolutionary aging theories
title_full_unstemmed A novel classification system for evolutionary aging theories
title_sort A novel classification system for evolutionary aging theories
author Trindade, Lucas S.
author_facet Trindade, Lucas S.
Aigaki, Toshiro
Peixoto, Alexandre A.
Balduíno, Alex
Cruz, Ivana B. Mânica
Heddle, Jonathan G.
author_role author
author2 Aigaki, Toshiro
Peixoto, Alexandre A.
Balduíno, Alex
Cruz, Ivana B. Mânica
Heddle, Jonathan G.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Trindade, Lucas S.
Aigaki, Toshiro
Peixoto, Alexandre A.
Balduíno, Alex
Cruz, Ivana B. Mânica
Heddle, Jonathan G.
dc.subject.en.pt_BR.fl_str_mv Senemorphism
Caloric restriction
Longevity
Altruism
Senescence
Evolution
topic Senemorphism
Caloric restriction
Longevity
Altruism
Senescence
Evolution
Envelhecimento
Altruísmo
Longevidade
Restrição Calórica
dc.subject.decs.pt_BR.fl_str_mv Envelhecimento
Altruísmo
Longevidade
Restrição Calórica
description Advanced Science Institute. Heddle Initiative Research Unit. Wako, Saitama, Japan / Nagasaki University. Graduate School of Biomedical Sciences. Department of Investigative Pathology. Nagasaki, Japan / Tokyo Metropolitan University. Department of Biological Sciences. Hachioji, Tokyo, Japanh.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2015-08-19T13:49:32Z
dc.date.available.fl_str_mv 2015-08-19T13:49:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TRINDADE, Lucas S.; et al. A novel classification system for evolutionary aging theories. Frontiers in Genetics, v.4, Art.25, 8p, March 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11558
dc.identifier.issn.pt_BR.fl_str_mv 1664-802
dc.identifier.doi.pt_BR.fl_str_mv 10.3389/fgene.2013.00025
identifier_str_mv TRINDADE, Lucas S.; et al. A novel classification system for evolutionary aging theories. Frontiers in Genetics, v.4, Art.25, 8p, March 2013.
1664-802
10.3389/fgene.2013.00025
url https://www.arca.fiocruz.br/handle/icict/11558
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media S.A
publisher.none.fl_str_mv Frontiers Media S.A
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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