Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function

Detalhes bibliográficos
Autor(a) principal: Macambira, Simone Garcia
Data de Publicação: 2009
Outros Autores: Vasconcelos, Juliana Fraga, Costa, Claudio R. S, Klein, Wilfried, Lima, Ricardo Santana de, Guimarães, Patrícia, Vidal, Daniel Torres Andion, Mendez, Lucas C, Santos, Ricardo Ribeiro dos, Soares, Milena Botelho Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1903
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Macambira, Simone GarciaVasconcelos, Juliana FragaCosta, Claudio R. SKlein, WilfriedLima, Ricardo Santana deGuimarães, PatríciaVidal, Daniel Torres AndionMendez, Lucas CSantos, Ricardo Ribeiro dosSoares, Milena Botelho Pereira2011-04-13T05:38:28Z2011-04-13T05:38:28Z2009MACAMBIRA, S. G. et al. Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function. FASEB Journal, v. 23, n. 11, p.3843-3850, 2009.1530-6860https://www.arca.fiocruz.br/handle/icict/190310.1096/fj.09-137869engGranulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and functioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Biologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThis study investigates the effects of granulocyte colony-stimulating factor (G-CSF) therapy in experimental chronic chagasic cardiomyopathy. Chagas disease is one of the leading causes of heart failure in Latin America and remains without an effective treatment other than cardiac transplantation. C57BL/6 mice were infected with 10(3) trypomastigotes of Trypanosoma cruzi, and chronic chagasic mice were treated with G-CSF or saline (control). Evaluations following treatment were functional, immunological, and histopathological. Comparing hearts of G-CSF-treated mice showed reduced inflammation and fibrosis compared to saline-treated chagasic mice. G-CSF treatment did not alter the parasite load but caused an increase in the number of apoptotic inflammatory cells in the heart. Cardiac conductance disturbances in all infected animals improved or remained stable due to the G-CSF treatment, whereas all of the saline-treated mice deteriorated. The distance run on a treadmill and the exercise time were significantly greater in G-CSF-treated mice when compared to chagasic controls, as well as oxygen consumption (VO(2)), carbon dioxide production (VCO(2)), and respiratory exchange ration (RER) during exercise. Administration of G-CSF in experimental cardiac ischemia had beneficial effects on cardiac structure, which were well correlated with improvements in cardiac function and whole animal performance.Chagasic cardiomyopathyInflammationarrhytmiasTreadmill performanceGranulócitos RecombinanteDoença de ChagasCardiomiopatia ChagásicaFator Estimulador de Colônias de Granulócitos Recombinanteinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGranulocyte colony-stimulating factor treatment in.pdfGranulocyte colony-stimulating factor treatment in.pdfapplication/pdf1316507https://www.arca.fiocruz.br/bitstream/icict/1903/1/Granulocyte%20colony-stimulating%20factor%20treatment%20in.pdf63c35205e5bb09d4d24366fe35a602bcMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/1903/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTGranulocyte colony-stimulating factor treatment in.pdf.txtGranulocyte colony-stimulating factor treatment in.pdf.txtExtracted texttext/plain37651https://www.arca.fiocruz.br/bitstream/icict/1903/5/Granulocyte%20colony-stimulating%20factor%20treatment%20in.pdf.txtd2474e54b6400cb005fd93a46fc653afMD55THUMBNAILGranulocyte colony-stimulating factor treatment in.pdf.jpgGranulocyte colony-stimulating factor treatment in.pdf.jpgGenerated Thumbnailimage/jpeg2525https://www.arca.fiocruz.br/bitstream/icict/1903/4/Granulocyte%20colony-stimulating%20factor%20treatment%20in.pdf.jpgf7c49449030c74fa481e98d34c520290MD54icict/19032023-03-15 14:33:23.853oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function
title Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function
spellingShingle Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function
Macambira, Simone Garcia
Chagasic cardiomyopathy
Inflammation
arrhytmias
Treadmill performance
Granulócitos Recombinante
Doença de Chagas
Cardiomiopatia Chagásica
Fator Estimulador de Colônias de Granulócitos Recombinante
title_short Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function
title_full Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function
title_fullStr Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function
title_full_unstemmed Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function
title_sort Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function
author Macambira, Simone Garcia
author_facet Macambira, Simone Garcia
Vasconcelos, Juliana Fraga
Costa, Claudio R. S
Klein, Wilfried
Lima, Ricardo Santana de
Guimarães, Patrícia
Vidal, Daniel Torres Andion
Mendez, Lucas C
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
author_role author
author2 Vasconcelos, Juliana Fraga
Costa, Claudio R. S
Klein, Wilfried
Lima, Ricardo Santana de
Guimarães, Patrícia
Vidal, Daniel Torres Andion
Mendez, Lucas C
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Macambira, Simone Garcia
Vasconcelos, Juliana Fraga
Costa, Claudio R. S
Klein, Wilfried
Lima, Ricardo Santana de
Guimarães, Patrícia
Vidal, Daniel Torres Andion
Mendez, Lucas C
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
dc.subject.en.pt_BR.fl_str_mv Chagasic cardiomyopathy
Inflammation
arrhytmias
Treadmill performance
topic Chagasic cardiomyopathy
Inflammation
arrhytmias
Treadmill performance
Granulócitos Recombinante
Doença de Chagas
Cardiomiopatia Chagásica
Fator Estimulador de Colônias de Granulócitos Recombinante
dc.subject.decs.pt_BR.fl_str_mv Granulócitos Recombinante
Doença de Chagas
Cardiomiopatia Chagásica
Fator Estimulador de Colônias de Granulócitos Recombinante
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2011-04-13T05:38:28Z
dc.date.available.fl_str_mv 2011-04-13T05:38:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACAMBIRA, S. G. et al. Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function. FASEB Journal, v. 23, n. 11, p.3843-3850, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1903
dc.identifier.issn.none.fl_str_mv 1530-6860
dc.identifier.doi.none.fl_str_mv 10.1096/fj.09-137869
identifier_str_mv MACAMBIRA, S. G. et al. Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function. FASEB Journal, v. 23, n. 11, p.3843-3850, 2009.
1530-6860
10.1096/fj.09-137869
url https://www.arca.fiocruz.br/handle/icict/1903
dc.language.iso.fl_str_mv eng
language eng
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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