Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial

Detalhes bibliográficos
Autor(a) principal: Santos, Ricardo Ribeiro dos
Data de Publicação: 2012
Outros Autores: Rassi, Salvador, Feitosa, Gilson Soares, Grecco, Oswaldo Tadeu, Rassi Junior, Anis, Cunha, Ademir Batista da, Carvalho, Valéria B de, Souza, Luiz César Guarita, Oliveira, Wilson de, Tura, Bernardo Rangel, Soares, Milena Botelho Pereira, Carvalho, Antonio Carlos Campos de, Chagas Arm of the MiHeart Study Investigators
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19436
Resumo: Santos, Ricardo Ribeiro dos; Soares, Milena Botelho Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Santos, Ricardo Ribeiro dosRassi, SalvadorFeitosa, Gilson SoaresGrecco, Oswaldo TadeuRassi Junior, AnisCunha, Ademir Batista daCarvalho, Valéria B deSouza, Luiz César GuaritaOliveira, Wilson deTura, Bernardo RangelSoares, Milena Botelho PereiraCarvalho, Antonio Carlos Campos deChagas Arm of the MiHeart Study Investigators2017-06-20T14:29:16Z2017-06-20T14:29:16Z2012SANTOS, R. R. et al. Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial. Circulation, v. 125, p. 2454-2461, 2012.)0009-7322https://www.arca.fiocruz.br/handle/icict/1943610.1161/CIRCULATIONAHA.111.067785Santos, Ricardo Ribeiro dos; Soares, Milena Botelho Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Hospital San Rafael. Salvador, BA, BrasilHospital das Clínicas de Goiania. Gioania, GO, BrasilHospital Santa Izabel. Salvador, BA, BrasilInstituto de Moléstias Cardiovasculares. São José do Rio Preto, SP, BrasilHospital do Coração Anis Rassi. Goiania, GO, BrasilInstituto Nacional de Cardiologia. Rio de Janeiro, RJ, BrasilHospital Sírio-Libanes. São Paulo, SP, BrasilPontifícia Universidade Católica do Paraná. Curitiba, PR, BrasilPronto Socorro Cardiológico de Pernambuco. Recife, PE, BrasilInstituto Nacional de Cardiologia. Rio de Janeiro, RJ, BrasilHospital San Rafael. Salvador, BA, BrasilInstituto Nacional de Cardiologia. Rio de Janeiro, RJ, BrasilPrevious studies suggested that transplantation of autologous bone marrow-derived mononuclear cells (BMNCs) improves heart function in chronic chagasic cardiomyopathy. We report the results of the first randomized trial of BMNC therapy in chronic chagasic cardiomyopathy. Methods and Results—Patients 18 to 75 years of age with chronic chagasic cardiomyopathy, New York Heart Association class II to IV heart failure, left ventricular ejection fraction (LVEF) 35%, and optimized therapy were randomized to intracoronary injection of autologous BMNCs or placebo. The primary end point was the difference in LVEF from baseline to 6 and 12 months after treatment between groups. Analysis was by intention to treat and powered to detect an absolute between-group difference of 5%. Between July 2005 and October 2009, 234 patients were enrolled. Two patients abandoned the study and 49 were excluded because of protocol violation. The remaining 183 patients, 93 in the placebo group and 90 in the BMNC group, had a trimmed mean age of 52.4 years (range, 50.8–54.0 years) and LVEF of 26.1% (range, 25.1%–27.1%) at baseline. Median number of injected BMNCs was 2.20 108 (range, 1.40–3.50 108). Change in LVEF did not differ significantly between treatment groups: trimmed mean change in LVEF at 6 months, 3.0 (1.3– 4.8) for BMNCs and 2.5 (0.6–4.5) for placebo (P 0.519); change in LVEF at 12 months, 3.5 (1.5–5.5) for BMNCs and 3.7 (1.5– 6.0) for placebo (P 0.850). Left ventricular systolic and diastolic volumes, New York Heart Association functional class, Minnesota quality-of-life questionnaire, brain natriuretic peptide concentrations, and 6-minute walking test did also not differ between groups. Conclusion—Intracoronary injection of autologous BMNCs does not improve left ventricular function or quality of life in patients with chronic chagasic cardiomyopathyengLippincott, Williams & WilkinsCardiomiopatiasCardiomiopatia chagásicaCélulas-troncoTerapia de tecidoCardiomyopathiesChagas cardiomyopathyStem cellsTissue therapyCell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19436/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRibeiro SR Cell therapy in chagas....pdfRibeiro SR Cell therapy in 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dc.title.pt_BR.fl_str_mv Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial
title Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial
spellingShingle Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial
Santos, Ricardo Ribeiro dos
Cardiomiopatias
Cardiomiopatia chagásica
Células-tronco
Terapia de tecido
Cardiomyopathies
Chagas cardiomyopathy
Stem cells
Tissue therapy
title_short Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial
title_full Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial
title_fullStr Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial
title_full_unstemmed Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial
title_sort Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial
author Santos, Ricardo Ribeiro dos
author_facet Santos, Ricardo Ribeiro dos
Rassi, Salvador
Feitosa, Gilson Soares
Grecco, Oswaldo Tadeu
Rassi Junior, Anis
Cunha, Ademir Batista da
Carvalho, Valéria B de
Souza, Luiz César Guarita
Oliveira, Wilson de
Tura, Bernardo Rangel
Soares, Milena Botelho Pereira
Carvalho, Antonio Carlos Campos de
Chagas Arm of the MiHeart Study Investigators
author_role author
author2 Rassi, Salvador
Feitosa, Gilson Soares
Grecco, Oswaldo Tadeu
Rassi Junior, Anis
Cunha, Ademir Batista da
Carvalho, Valéria B de
Souza, Luiz César Guarita
Oliveira, Wilson de
Tura, Bernardo Rangel
Soares, Milena Botelho Pereira
Carvalho, Antonio Carlos Campos de
Chagas Arm of the MiHeart Study Investigators
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Ricardo Ribeiro dos
Rassi, Salvador
Feitosa, Gilson Soares
Grecco, Oswaldo Tadeu
Rassi Junior, Anis
Cunha, Ademir Batista da
Carvalho, Valéria B de
Souza, Luiz César Guarita
Oliveira, Wilson de
Tura, Bernardo Rangel
Soares, Milena Botelho Pereira
Carvalho, Antonio Carlos Campos de
Chagas Arm of the MiHeart Study Investigators
dc.subject.other.pt_BR.fl_str_mv Cardiomiopatias
Cardiomiopatia chagásica
Células-tronco
Terapia de tecido
topic Cardiomiopatias
Cardiomiopatia chagásica
Células-tronco
Terapia de tecido
Cardiomyopathies
Chagas cardiomyopathy
Stem cells
Tissue therapy
dc.subject.en.pt_BR.fl_str_mv Cardiomyopathies
Chagas cardiomyopathy
Stem cells
Tissue therapy
description Santos, Ricardo Ribeiro dos; Soares, Milena Botelho Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-06-20T14:29:16Z
dc.date.available.fl_str_mv 2017-06-20T14:29:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, R. R. et al. Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial. Circulation, v. 125, p. 2454-2461, 2012.)
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19436
dc.identifier.issn.pt_BR.fl_str_mv 0009-7322
dc.identifier.doi.none.fl_str_mv 10.1161/CIRCULATIONAHA.111.067785
identifier_str_mv SANTOS, R. R. et al. Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial. Circulation, v. 125, p. 2454-2461, 2012.)
0009-7322
10.1161/CIRCULATIONAHA.111.067785
url https://www.arca.fiocruz.br/handle/icict/19436
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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