Current status and perspectives of cell therapy in Chagas disease

Detalhes bibliográficos
Autor(a) principal: Soares, Milena Botelho Pereira
Data de Publicação: 2009
Outros Autores: Santos, Ricardo Ribeiro dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1880
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Soares, Milena Botelho PereiraSantos, Ricardo Ribeiro dos2011-04-06T15:54:38Z2011-04-06T15:54:38Z2009SOARES, M. B. P.; SANTOS, R. R. dos. Current status and perspectives of cell therapy in Chagas disease. Memórias do Instituto Oswaldo Cruz, v.104, supl.1, p.325-332, 2009.0074-0276https://www.arca.fiocruz.br/handle/icict/188010.1590/S0074-02762009000900043engCurrent status and perspectives of cell therapy in Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilOne century after its discovery, Chagas disease, caused by the protozoan, Trypanosoma cruzi, remains a major health problem in Latin America. Mortality and morbidity are mainly due to chronic processes that lead to dysfunction of the cardiac and digestive systems. About one third of the chronic chagasic individuals have or will develop the symptomatic forms of the disease, with cardiomyopathy being the most common chronic form. This is a progressively debilitating disease for which there are no currently available effective treatments other than heart transplantation. Like in other cardiac diseases, tissue engineering and cell therapy have been investigated in the past few years as a means of recovering the heart function lost as a consequence of chronic damage caused by the immune-mediated pathogenic mechanisms elicited in individuals with chronic chagasic cardiomyopathy. Here we review the studies of cell therapy in animal models and patients with chronic Chagas disease and the perspectives of the recovery of the heart function lost due to infection with T. cruzi.Chagas diseaseCardiomyopathyCellular therapyStem cellsTissue inflammationFibrosisCardiomiopatia Chagásica/SUTransplante de Células-Tronco MesenquimaisTransplante de Medula Ósseainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCurrent status and perspectives of cell therapy in Chagas.pdfCurrent status and perspectives of cell therapy in Chagas.pdfapplication/pdf1147286https://www.arca.fiocruz.br/bitstream/icict/1880/1/Current%20status%20and%20perspectives%20of%20cell%20therapy%20in%20Chagas.pdfbee8d174829fe005623bce84f49a16e9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/1880/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTCurrent status and perspectives of cell therapy in Chagas.pdf.txtCurrent status and perspectives of cell therapy in Chagas.pdf.txtExtracted texttext/plain44728https://www.arca.fiocruz.br/bitstream/icict/1880/5/Current%20status%20and%20perspectives%20of%20cell%20therapy%20in%20Chagas.pdf.txt46a846c8a9e8d6c3a4e29360c11b9d7eMD55THUMBNAILCurrent status and perspectives of cell therapy in Chagas.pdf.jpgCurrent status and perspectives of cell therapy in Chagas.pdf.jpgGenerated Thumbnailimage/jpeg2225https://www.arca.fiocruz.br/bitstream/icict/1880/4/Current%20status%20and%20perspectives%20of%20cell%20therapy%20in%20Chagas.pdf.jpge4e184305b45d45958d13c7a5df96455MD54icict/18802023-03-15 14:33:24.261oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:24Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Current status and perspectives of cell therapy in Chagas disease
title Current status and perspectives of cell therapy in Chagas disease
spellingShingle Current status and perspectives of cell therapy in Chagas disease
Soares, Milena Botelho Pereira
Chagas disease
Cardiomyopathy
Cellular therapy
Stem cells
Tissue inflammation
Fibrosis
Cardiomiopatia Chagásica/SU
Transplante de Células-Tronco Mesenquimais
Transplante de Medula Óssea
title_short Current status and perspectives of cell therapy in Chagas disease
title_full Current status and perspectives of cell therapy in Chagas disease
title_fullStr Current status and perspectives of cell therapy in Chagas disease
title_full_unstemmed Current status and perspectives of cell therapy in Chagas disease
title_sort Current status and perspectives of cell therapy in Chagas disease
author Soares, Milena Botelho Pereira
author_facet Soares, Milena Botelho Pereira
Santos, Ricardo Ribeiro dos
author_role author
author2 Santos, Ricardo Ribeiro dos
author2_role author
dc.contributor.author.fl_str_mv Soares, Milena Botelho Pereira
Santos, Ricardo Ribeiro dos
dc.subject.en.pt_BR.fl_str_mv Chagas disease
Cardiomyopathy
Cellular therapy
Stem cells
Tissue inflammation
Fibrosis
topic Chagas disease
Cardiomyopathy
Cellular therapy
Stem cells
Tissue inflammation
Fibrosis
Cardiomiopatia Chagásica/SU
Transplante de Células-Tronco Mesenquimais
Transplante de Medula Óssea
dc.subject.decs.pt_BR.fl_str_mv Cardiomiopatia Chagásica/SU
Transplante de Células-Tronco Mesenquimais
Transplante de Medula Óssea
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2011-04-06T15:54:38Z
dc.date.available.fl_str_mv 2011-04-06T15:54:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, M. B. P.; SANTOS, R. R. dos. Current status and perspectives of cell therapy in Chagas disease. Memórias do Instituto Oswaldo Cruz, v.104, supl.1, p.325-332, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1880
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762009000900043
identifier_str_mv SOARES, M. B. P.; SANTOS, R. R. dos. Current status and perspectives of cell therapy in Chagas disease. Memórias do Instituto Oswaldo Cruz, v.104, supl.1, p.325-332, 2009.
0074-0276
10.1590/S0074-02762009000900043
url https://www.arca.fiocruz.br/handle/icict/1880
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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