CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45487 |
Resumo: | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Laboratório de Patologia Comparativa. Belo Horizonte, MG, Brasil. |
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Mattos, Matheus SilverioFerrero, Maximiliano RubenKraemer, LucasLopes, Gabriel Augusto OliveiraReis, Diego CarlosCassali, Geovanni DantasOliveira, Fabrício Marcus SilvaBrandolini, LauraAllegretti, MarcelloGarcia, Cristiana CoutoMartins, Marco AurélioTeixeira, Mauro MartinsRusso, Remo Castro2021-01-02T18:05:26Z2021-01-02T18:05:26Z2020MATTOS, Matheus Silverio et al. CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice. Frontiers in Immunology, v. 11, Article 566953, p. 1-22, Oct. 2020.1664-3224https://www.arca.fiocruz.br/handle/icict/4548710.3389/fimmu.2020.566953engFrontiers MediaNeutrófilos (PMNs)AsmaFibroseDoença pulmonar obstrutiva crônicaInfluenza A (H1N1)Neutrophils (PMNs)AsthmaFibrosisChronic obstructive pulmonary diseaseInfluenza A (H1N1)CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Laboratório de Patologia Comparativa. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Laboratório de Patologia Comparativa. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Laboratório de Patologia Comparativa. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Laboratório de Patologia Comparada. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Laboratório de Patologia Comparada. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Laboratório de Patologia Comparada. Belo Horizonte, MG, Brasil.R&D Department, Dompé Farmaceutici S.p.a., L’Aquila, Italy.R&D Department, Dompé Farmaceutici S.p.a., L’Aquila, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Laboratório de Imunofarmacologia. Belo Horizonte, MG, Brasil.Rationale: Increased IL-8 levels and neutrophil accumulation in the airways are common features found in patients affected by pulmonary diseases such as Asthma, Idiopathic Pulmonary Fibrosis, Influenza-A infection and COPD. Chronic neutrophilic inflammation is usually corticosteroid insensitive and may be relevant in the progression of those diseases. Objective: To explore the role of Ladarixin, a dual CXCR1/2 antagonist, in several mouse models of airway inflammation with a significant neutrophilic component. Findings: Ladarixin was able to reduce the acute and chronic neutrophilic influx, also attenuating the Th2 eosinophil-dominated airway inflammation, tissue remodeling and airway hyperresponsiveness. Correspondingly, Ladarixin decreased bleomycin-induced neutrophilic inflammation and collagen deposition, as well as attenuated the corticosteroid resistant Th17 neutrophil-dominated airway inflammation and hyperresponsiveness, restoring corticosteroid sensitivity. Finally, Ladarixin reduced neutrophilic airway inflammation during cigarette smoke-induced corticosteroid resistant exacerbation of Influenza-A infection, improving lung function and mice survival. Conclusion: CXCR1/2 antagonist Ladarixin offers a new strategy for therapeutic treatment of acute and chronic neutrophilic airway inflammation, even in the context of corticosteroid-insensitivity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45487/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMAMartins_MaximilianoFerrero_etal_IOC_2020.pdfMAMartins_MaximilianoFerrero_etal_IOC_2020.pdfapplication/pdf12394299https://www.arca.fiocruz.br/bitstream/icict/45487/2/MAMartins_MaximilianoFerrero_etal_IOC_2020.pdf17c76cf79746dbbd26744c79e9f50c28MD52TEXTMAMartins_MaximilianoFerrero_etal_IOC_2020.pdf.txtMAMartins_MaximilianoFerrero_etal_IOC_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice |
| title |
CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice |
| spellingShingle |
CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice Mattos, Matheus Silverio Neutrófilos (PMNs) Asma Fibrose Doença pulmonar obstrutiva crônica Influenza A (H1N1) Neutrophils (PMNs) Asthma Fibrosis Chronic obstructive pulmonary disease Influenza A (H1N1) |
| title_short |
CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice |
| title_full |
CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice |
| title_fullStr |
CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice |
| title_full_unstemmed |
CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice |
| title_sort |
CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice |
| author |
Mattos, Matheus Silverio |
| author_facet |
Mattos, Matheus Silverio Ferrero, Maximiliano Ruben Kraemer, Lucas Lopes, Gabriel Augusto Oliveira Reis, Diego Carlos Cassali, Geovanni Dantas Oliveira, Fabrício Marcus Silva Brandolini, Laura Allegretti, Marcello Garcia, Cristiana Couto Martins, Marco Aurélio Teixeira, Mauro Martins Russo, Remo Castro |
| author_role |
author |
| author2 |
Ferrero, Maximiliano Ruben Kraemer, Lucas Lopes, Gabriel Augusto Oliveira Reis, Diego Carlos Cassali, Geovanni Dantas Oliveira, Fabrício Marcus Silva Brandolini, Laura Allegretti, Marcello Garcia, Cristiana Couto Martins, Marco Aurélio Teixeira, Mauro Martins Russo, Remo Castro |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mattos, Matheus Silverio Ferrero, Maximiliano Ruben Kraemer, Lucas Lopes, Gabriel Augusto Oliveira Reis, Diego Carlos Cassali, Geovanni Dantas Oliveira, Fabrício Marcus Silva Brandolini, Laura Allegretti, Marcello Garcia, Cristiana Couto Martins, Marco Aurélio Teixeira, Mauro Martins Russo, Remo Castro |
| dc.subject.other.pt_BR.fl_str_mv |
Neutrófilos (PMNs) Asma Fibrose Doença pulmonar obstrutiva crônica Influenza A (H1N1) |
| topic |
Neutrófilos (PMNs) Asma Fibrose Doença pulmonar obstrutiva crônica Influenza A (H1N1) Neutrophils (PMNs) Asthma Fibrosis Chronic obstructive pulmonary disease Influenza A (H1N1) |
| dc.subject.en.pt_BR.fl_str_mv |
Neutrophils (PMNs) Asthma Fibrosis Chronic obstructive pulmonary disease Influenza A (H1N1) |
| description |
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Laboratório de Patologia Comparativa. Belo Horizonte, MG, Brasil. |
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2020 |
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2020 |
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2021-01-02T18:05:26Z |
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2021-01-02T18:05:26Z |
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info:eu-repo/semantics/publishedVersion |
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MATTOS, Matheus Silverio et al. CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice. Frontiers in Immunology, v. 11, Article 566953, p. 1-22, Oct. 2020. |
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https://www.arca.fiocruz.br/handle/icict/45487 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2020.566953 |
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MATTOS, Matheus Silverio et al. CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice. Frontiers in Immunology, v. 11, Article 566953, p. 1-22, Oct. 2020. 1664-3224 10.3389/fimmu.2020.566953 |
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