Modulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44702 |
Resumo: | Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil. |
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Aliberti, Júlio C. S.Souto, Janeusa T.Marino, Ana P. M. P.Lannes-Vieira, JoseliTeixeira, Mauro M.Farber, JoshuaGazzinelli, Ricardo T.Silva, João S.2020-12-02T14:19:24Z2020-12-02T14:19:24Z2011ALBERTI, Júlio C. S. et al. Modulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infection. American Journal of Pathology, v. 158, n. 4, p. 1-8, Apr. 2001.0002-9440https://www.arca.fiocruz.br/handle/icict/4470210.1016/s0002-9440(10)64094-11525-2191engAmerican Society for Investigative PathologyInfecção por Trypanosoma cruziInterferon-YTumor Necrosis Factor-R1Respostas inflamatóriasQuimiocinasRatos deficientesTrypanosoma cruzi InfectionInterferon-YTumor necrosis factor R1Chemokine ProductionDeficient MiceModulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil.National Institutes of Health. National Institutes of Allergy and Infectious Diseases. Laboratory of Clinical Investigation. Bethesda, MD, USA.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.Infection with Trypanosoma cruzi causes a strong inflammatory reaction at the inoculation site and, later, in the myocardium. The present study investigates the role of cytokines as modulators of T. cruziinduced chemokine expression in vivo and in vitro. In macrophage cultures, although the stimulation with interferon (IFN)-g increases the expression of IP-10, it blocks KC expression. Tumor necrosis factor (TNF)-a, on the other hand, potentiates KC, IP-10, macrophage inflammatory protein-1a, and JE/monocyte chemotatic protein-1 expression. Interleukin-10 and transforming growth factor-b inhibited almost all chemokines tested. The role of IFN-g and TNF-a in chemokine modulation during infection was investigated in T. cruzi-infected IFN-g-deficient (GKO) or TNFR1/ p55-deficient (p552/2) mice. The expression of chemokines detected in the inoculation site correlated with the infiltrating cell type observed. Although GKO mice had a delayed and intense neutrophilic infiltrate correlating with the expression of KC and macrophage inflammatory protein-2, none of the above was observed in p552/2 mice. The detection of infiltrating T cells, Mig, and IP-10 in the myocardium was observed in wild-type and p552/2, but not in GKO mice. Together, these results suggest that the regulatory roles of IFN-g and TNF-a on chemokine expression may play a crucial role in the modulation of the inflammatory response during T. cruzi infection and mediate resistance to infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44702/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAnaPMMarino_JoseliLVieira_etal_IOC_2001.pdfAnaPMMarino_JoseliLVieira_etal_IOC_2001.pdfapplication/pdf1999704https://www.arca.fiocruz.br/bitstream/icict/44702/2/AnaPMMarino_JoseliLVieira_etal_IOC_2001.pdf93dfd3c2fe2f9d8ffa999016e3f1835eMD52TEXTAnaPMMarino_JoseliLVieira_etal_IOC_2001.pdf.txtAnaPMMarino_JoseliLVieira_etal_IOC_2001.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Modulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infection |
| title |
Modulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infection |
| spellingShingle |
Modulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infection Aliberti, Júlio C. S. Infecção por Trypanosoma cruzi Interferon-Y Tumor Necrosis Factor-R1 Respostas inflamatórias Quimiocinas Ratos deficientes Trypanosoma cruzi Infection Interferon-Y Tumor necrosis factor R1 Chemokine Production Deficient Mice |
| title_short |
Modulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infection |
| title_full |
Modulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infection |
| title_fullStr |
Modulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infection |
| title_full_unstemmed |
Modulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infection |
| title_sort |
Modulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infection |
| author |
Aliberti, Júlio C. S. |
| author_facet |
Aliberti, Júlio C. S. Souto, Janeusa T. Marino, Ana P. M. P. Lannes-Vieira, Joseli Teixeira, Mauro M. Farber, Joshua Gazzinelli, Ricardo T. Silva, João S. |
| author_role |
author |
| author2 |
Souto, Janeusa T. Marino, Ana P. M. P. Lannes-Vieira, Joseli Teixeira, Mauro M. Farber, Joshua Gazzinelli, Ricardo T. Silva, João S. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Aliberti, Júlio C. S. Souto, Janeusa T. Marino, Ana P. M. P. Lannes-Vieira, Joseli Teixeira, Mauro M. Farber, Joshua Gazzinelli, Ricardo T. Silva, João S. |
| dc.subject.other.pt_BR.fl_str_mv |
Infecção por Trypanosoma cruzi Interferon-Y Tumor Necrosis Factor-R1 Respostas inflamatórias Quimiocinas Ratos deficientes |
| topic |
Infecção por Trypanosoma cruzi Interferon-Y Tumor Necrosis Factor-R1 Respostas inflamatórias Quimiocinas Ratos deficientes Trypanosoma cruzi Infection Interferon-Y Tumor necrosis factor R1 Chemokine Production Deficient Mice |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Infection Interferon-Y Tumor necrosis factor R1 Chemokine Production Deficient Mice |
| description |
Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil. |
| publishDate |
2011 |
| dc.date.issued.fl_str_mv |
2011 |
| dc.date.accessioned.fl_str_mv |
2020-12-02T14:19:24Z |
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2020-12-02T14:19:24Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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ALBERTI, Júlio C. S. et al. Modulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infection. American Journal of Pathology, v. 158, n. 4, p. 1-8, Apr. 2001. |
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https://www.arca.fiocruz.br/handle/icict/44702 |
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0002-9440 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/s0002-9440(10)64094-1 |
| dc.identifier.eissn.none.fl_str_mv |
1525-2191 |
| identifier_str_mv |
ALBERTI, Júlio C. S. et al. Modulation of Chemokine Production and Inflammatory Responses in Interferon-g- and Tumor Necrosis Factor-R1-Deficient Mice during Trypanosoma cruzi Infection. American Journal of Pathology, v. 158, n. 4, p. 1-8, Apr. 2001. 0002-9440 10.1016/s0002-9440(10)64094-1 1525-2191 |
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American Society for Investigative Pathology |
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American Society for Investigative Pathology |
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