Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1999 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1086/315082 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20072 |
Resumo: | Ko, Albert Icksang “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Almeida, Roque Pacheco deD'Oliveira Júnior, ArgemiroMachado, Paulo Roberto LimaBacellar, Maria Olívia Amado RamosKo, Albert IcksangJesus, Amélia Maria Ribeiro deMobashery, NSantos, Jussamara BritoCarvalho Filho, Edgar Marcelino2017-07-13T13:38:18Z2017-07-13T13:38:18Z1999ALMEIDA, R. P. et al. Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis. Journal of Infectious Diseases, v. 180, p. 1735–1737, 1999.0022-1899https://www.arca.fiocruz.br/handle/icict/2007210.1086/315082Ko, Albert Icksang “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.National Institutes of Health grant AI-30639 and by Financiadora de Estudos e Projetos, Centro de Apoio ao Desenvolvimento da Ciência e Tecnologia, and Programa de Apoio aos Núcleos de Excelência.Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilHospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilHospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilHospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilCornell University Medical College. NY Hospital. Division of International Health and Infectious Diseases. Department of Medicine. New York, NYHospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilCornell University Medical College. NY Hospital. Division of International Health and Infectious Diseases. Department of Medicine. New York, NYHospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilHospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilThe response to recombinant human granulocyte macrophage colony-stimulating factor (GM-CSF) in the treatment of cutaneous leishmaniasis was evaluated. Twenty patients with cutaneous leishmaniasis who had lesions for 60 days were enrolled in a double-blind placebo trial of GM-CSF with standard parenteral sodium stibogluconate (20 mg/kg-1/day-1) for 20 days. Ten patients were randomized to receive intralesionally injected GM-CSF (200 microgram) at enrollment and 1 week after, and 10 patients received saline as placebo. GM-CSF- and antimony-treated patients healed faster than patients who received antimony alone (49+/-32.8 vs. 110+/-61.6 days, P<.05). Seven of 10 patients were healed of their lesions before 40 days after therapy in the GM-CSF group, compared with only 1 of 10 patients in the placebo group (relative risk, 7; 95% confidence interval, 1.04-47.00). Thus, GM-CSF plus antimony significantly increased the chance of lesion healing in 40 days.engOxford University PressLeishmaniose cutâneaGluconato de antimônio e sódioAgentes antiprotozoáriosFator Estimulador de Colônia de GranulócitosCriançaHumanosLeishmaniasis, CutaneousAntimony Sodium GluconateAntiprotozoal AgentsGranulocyte-Macrophage Colony-Stimulating FactorChildHumansRandomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20072/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAlmeida R Randomized, double-blind study of.... .pdfAlmeida R 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| dc.title.pt_BR.fl_str_mv |
Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis |
| title |
Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis |
| spellingShingle |
Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis Almeida, Roque Pacheco de Leishmaniose cutânea Gluconato de antimônio e sódio Agentes antiprotozoários Fator Estimulador de Colônia de Granulócitos Criança Humanos Leishmaniasis, Cutaneous Antimony Sodium Gluconate Antiprotozoal Agents Granulocyte-Macrophage Colony-Stimulating Factor Child Humans |
| title_short |
Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis |
| title_full |
Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis |
| title_fullStr |
Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis |
| title_full_unstemmed |
Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis |
| title_sort |
Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis |
| author |
Almeida, Roque Pacheco de |
| author_facet |
Almeida, Roque Pacheco de D'Oliveira Júnior, Argemiro Machado, Paulo Roberto Lima Bacellar, Maria Olívia Amado Ramos Ko, Albert Icksang Jesus, Amélia Maria Ribeiro de Mobashery, N Santos, Jussamara Brito Carvalho Filho, Edgar Marcelino |
| author_role |
author |
| author2 |
D'Oliveira Júnior, Argemiro Machado, Paulo Roberto Lima Bacellar, Maria Olívia Amado Ramos Ko, Albert Icksang Jesus, Amélia Maria Ribeiro de Mobashery, N Santos, Jussamara Brito Carvalho Filho, Edgar Marcelino |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Almeida, Roque Pacheco de D'Oliveira Júnior, Argemiro Machado, Paulo Roberto Lima Bacellar, Maria Olívia Amado Ramos Ko, Albert Icksang Jesus, Amélia Maria Ribeiro de Mobashery, N Santos, Jussamara Brito Carvalho Filho, Edgar Marcelino |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose cutânea Gluconato de antimônio e sódio Agentes antiprotozoários Fator Estimulador de Colônia de Granulócitos Criança Humanos |
| topic |
Leishmaniose cutânea Gluconato de antimônio e sódio Agentes antiprotozoários Fator Estimulador de Colônia de Granulócitos Criança Humanos Leishmaniasis, Cutaneous Antimony Sodium Gluconate Antiprotozoal Agents Granulocyte-Macrophage Colony-Stimulating Factor Child Humans |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis, Cutaneous Antimony Sodium Gluconate Antiprotozoal Agents Granulocyte-Macrophage Colony-Stimulating Factor Child Humans |
| description |
Ko, Albert Icksang “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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1999 |
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1999 |
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2017-07-13T13:38:18Z |
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2017-07-13T13:38:18Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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ALMEIDA, R. P. et al. Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis. Journal of Infectious Diseases, v. 180, p. 1735–1737, 1999. |
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https://www.arca.fiocruz.br/handle/icict/20072 |
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0022-1899 |
| dc.identifier.doi.none.fl_str_mv |
10.1086/315082 |
| identifier_str_mv |
ALMEIDA, R. P. et al. Randomized, double-blind study of stibogluconate plus human granulocyte macrophage colony-stimulating factor versus stibogluconate alone in the treatment of cutaneous Leishmaniasis. Journal of Infectious Diseases, v. 180, p. 1735–1737, 1999. 0022-1899 10.1086/315082 |
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Oxford University Press |
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Oxford University Press |
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