Role of extracellular matrix-mediated interactions in thymocyte migration

Detalhes bibliográficos
Autor(a) principal: Savino, Wilson
Data de Publicação: 2000
Outros Autores: Dalmau, Sérgio Ranto, Almeida, Vinícius Cotta de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42063
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
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spelling Savino, WilsonDalmau, Sérgio RantoAlmeida, Vinícius Cotta de2020-07-03T17:40:13Z2020-07-03T17:40:13Z2000SAVINO, Wilson; DALMAU, Sérgio Ranto; ALMEIDA, Vinícius Cotta de. Role of extracellular matrix-mediated interactions in thymocyte migration. Clinical and Developmental Immunology, v. 7, n. 2-4, p. 279-291, 2000.1740-2522https://www.arca.fiocruz.br/handle/icict/4206310.1155/2000/602471740-2530engHindawiTimoFibronectinaLamininaIntegrinasLinfócitosCélulas epiteliais tímicasThymusFibronectinLamininIntegrinsLymphocytesThymic epithelial cellsRole of extracellular matrix-mediated interactions in thymocyte migrationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Centro Biomédico. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Centro de Pesquisa Básica. Programa de Medicina Experimental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Cell adhesion, migration, differentiation and survival or death is amongst a large spectrum of biological responses that can be elicited by ligation of extracellular matrix components to their corresponding receptors. As regards the physiology of the thymus, cell migration is a crucial event in the general process of T cell differentiation. Studies on the intrathymic distribution of ECM components revealed that fibronectin, laminin and type IV collagen, are not restrictedly located at typical basement membrane sites, also forming a thick network in the medullary region of the thymic lobules, whereas very thin ECM fibers are found within the cortex. These ECM components are essentially produced by thymic microenvironmental cells, which also drive thymocyte differentiation. Signals triggered by ECM are conveyed into thymocytes or microenvironmental cells through specific membrane receptors, and most of them belong to the integrin type, such as the VLA-3, VLA-4, VLA-5 and VLA-6. In vitro studies revealed that adhesion of thymocytes to thymic microenvironmental cells is mediated by extracellular matrix. Such an adhesion is preferentially done by immature thymocytes. Importantly, ECM-mediated interactions also govern the entrance and exit of thymocytes in the lymphoepithelial complexes named thymic nurse cells. Lastly, pathological conditions, including infectious and autoimmune diseases, in which changes of ECM ligands and receptors are observed, course with alterations in thymocyte migration and death. In conclusion, the fact that ECM can modulate traffic, differentiation, death and survival of normal thymocytes adds clues for understanding how ECM-mediated interactions behave in the thymus, not only in normal, but also in pathological conditions.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42063/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_ViniciusCAlmeida_etal_IOC_2000.pdfWilsonSavino_ViniciusCAlmeida_etal_IOC_2000.pdfapplication/pdf2637911https://www.arca.fiocruz.br/bitstream/icict/42063/2/WilsonSavino_ViniciusCAlmeida_etal_IOC_2000.pdf6648e5a17c68900e701da1abe9b8e767MD52TEXTWilsonSavino_ViniciusCAlmeida_etal_IOC_2000.pdf.txtWilsonSavino_ViniciusCAlmeida_etal_IOC_2000.pdf.txtExtracted 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dc.title.en.fl_str_mv Role of extracellular matrix-mediated interactions in thymocyte migration
title Role of extracellular matrix-mediated interactions in thymocyte migration
spellingShingle Role of extracellular matrix-mediated interactions in thymocyte migration
Savino, Wilson
Timo
Fibronectina
Laminina
Integrinas
Linfócitos
Células epiteliais tímicas
Thymus
Fibronectin
Laminin
Integrins
Lymphocytes
Thymic epithelial cells
title_short Role of extracellular matrix-mediated interactions in thymocyte migration
title_full Role of extracellular matrix-mediated interactions in thymocyte migration
title_fullStr Role of extracellular matrix-mediated interactions in thymocyte migration
title_full_unstemmed Role of extracellular matrix-mediated interactions in thymocyte migration
title_sort Role of extracellular matrix-mediated interactions in thymocyte migration
author Savino, Wilson
author_facet Savino, Wilson
Dalmau, Sérgio Ranto
Almeida, Vinícius Cotta de
author_role author
author2 Dalmau, Sérgio Ranto
Almeida, Vinícius Cotta de
author2_role author
author
dc.contributor.author.fl_str_mv Savino, Wilson
Dalmau, Sérgio Ranto
Almeida, Vinícius Cotta de
dc.subject.other.pt_BR.fl_str_mv Timo
Fibronectina
Laminina
Integrinas
Linfócitos
Células epiteliais tímicas
topic Timo
Fibronectina
Laminina
Integrinas
Linfócitos
Células epiteliais tímicas
Thymus
Fibronectin
Laminin
Integrins
Lymphocytes
Thymic epithelial cells
dc.subject.en.en.fl_str_mv Thymus
Fibronectin
Laminin
Integrins
Lymphocytes
Thymic epithelial cells
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2020-07-03T17:40:13Z
dc.date.available.fl_str_mv 2020-07-03T17:40:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SAVINO, Wilson; DALMAU, Sérgio Ranto; ALMEIDA, Vinícius Cotta de. Role of extracellular matrix-mediated interactions in thymocyte migration. Clinical and Developmental Immunology, v. 7, n. 2-4, p. 279-291, 2000.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42063
dc.identifier.issn.pt_BR.fl_str_mv 1740-2522
dc.identifier.doi.pt_BR.fl_str_mv 10.1155/2000/60247
dc.identifier.eissn.pt_BR.fl_str_mv 1740-2530
identifier_str_mv SAVINO, Wilson; DALMAU, Sérgio Ranto; ALMEIDA, Vinícius Cotta de. Role of extracellular matrix-mediated interactions in thymocyte migration. Clinical and Developmental Immunology, v. 7, n. 2-4, p. 279-291, 2000.
1740-2522
10.1155/2000/60247
1740-2530
url https://www.arca.fiocruz.br/handle/icict/42063
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/42063/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/42063/2/WilsonSavino_ViniciusCAlmeida_etal_IOC_2000.pdf
https://www.arca.fiocruz.br/bitstream/icict/42063/3/WilsonSavino_ViniciusCAlmeida_etal_IOC_2000.pdf.txt
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