Laminin-Mediated interactions in Thymocyte Migration and Development

Detalhes bibliográficos
Autor(a) principal: Savino, Wilson
Data de Publicação: 2015
Outros Autores: Cruz, Daniella Arêas Mendes da, Golbert, Daiane Cristina Ferreira, Riederer, Ingo, Almeida, Vinicius Cotta de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13776
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
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spelling Savino, WilsonCruz, Daniella Arêas Mendes daGolbert, Daiane Cristina FerreiraRiederer, IngoAlmeida, Vinicius Cotta de2016-04-14T16:20:34Z2016-04-14T16:20:34Z2015SAVINO, Wilson; et al. Laminin-Mediated Interactions in Thymocyte Migration and Development. Frontiers in Immunology, v.6, Article 579, 13p, Nov. 2015.1664-3224https://www.arca.fiocruz.br/handle/icict/1377610.3389/fimmu.2015.00579engFrontiers MediaLaminin-Mediated interactions in Thymocyte Migration and Developmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Intrathymic T-cell differentiation is a key process for the development and maintenance of cell-mediated immunity, and occurs concomitantly to highly regulated migratory events. We have proposed a multivectorial model for describing intrathymic thymocyte migration. One of the individual vectors comprises interactions mediated by laminins (LMs), a heterotrimeric protein family of the extracellular matrix. Several LMs are expressed in the thymus, being produced by microenvironmental cells, particularly thymic epithelial cells (TECs). Also, thymocytes and epithelial cells express integrin-type LM receptors. Functionally, it has been reported that the dy/dy mutant mouse (lacking the LM isoform 211) exhibits defective thymocyte differentiation. Several data show haptotactic effects of LMs upon thymocytes, as well as their adhesion on TECs; both effects being prevented by anti-LM or anti-LM receptor antibodies. Interestingly, LM synergizes with chemokines to enhance thymocyte migration, whereas classe-3 semaphorins and B ephrins, which exhibit chemorepulsive effects in the thymus, downregulate LM-mediated migratory responses of thymocytes. More recently, we showed that knocking down the ITGA6 gene (which encodes the α6 integrin chain of LM receptors) in human TECs modulates a large number of cell migration-related genes and results in changes of adhesion pattern of thymocytes onto the thymic epithelium. Overall, LM-mediated interactions can be placed at the cross-road of the multivectorial process of thymocyte migration, with a direct influence per se, as well as by modulating other molecular interactions associated with the intrathymic-trafficking events.ThymusT-cell developmentThymic epithelial cellsExtracellular matrixLaminin isoformsIntegrinsChemokinesTimoCélulas EpiteliaisMatriz ExtracelularLamininaIsoformasIntegrinasQuimiocinasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Laminin-Mediated interactions in Thymocyte Migration and Development
title Laminin-Mediated interactions in Thymocyte Migration and Development
spellingShingle Laminin-Mediated interactions in Thymocyte Migration and Development
Savino, Wilson
Thymus
T-cell development
Thymic epithelial cells
Extracellular matrix
Laminin isoforms
Integrins
Chemokines
Timo
Células Epiteliais
Matriz Extracelular
Laminina
Isoformas
Integrinas
Quimiocinas
title_short Laminin-Mediated interactions in Thymocyte Migration and Development
title_full Laminin-Mediated interactions in Thymocyte Migration and Development
title_fullStr Laminin-Mediated interactions in Thymocyte Migration and Development
title_full_unstemmed Laminin-Mediated interactions in Thymocyte Migration and Development
title_sort Laminin-Mediated interactions in Thymocyte Migration and Development
author Savino, Wilson
author_facet Savino, Wilson
Cruz, Daniella Arêas Mendes da
Golbert, Daiane Cristina Ferreira
Riederer, Ingo
Almeida, Vinicius Cotta de
author_role author
author2 Cruz, Daniella Arêas Mendes da
Golbert, Daiane Cristina Ferreira
Riederer, Ingo
Almeida, Vinicius Cotta de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Savino, Wilson
Cruz, Daniella Arêas Mendes da
Golbert, Daiane Cristina Ferreira
Riederer, Ingo
Almeida, Vinicius Cotta de
dc.subject.en.pt_BR.fl_str_mv Thymus
T-cell development
Thymic epithelial cells
Extracellular matrix
Laminin isoforms
Integrins
Chemokines
topic Thymus
T-cell development
Thymic epithelial cells
Extracellular matrix
Laminin isoforms
Integrins
Chemokines
Timo
Células Epiteliais
Matriz Extracelular
Laminina
Isoformas
Integrinas
Quimiocinas
dc.subject.decs.pt_BR.fl_str_mv Timo
Células Epiteliais
Matriz Extracelular
Laminina
Isoformas
Integrinas
Quimiocinas
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-14T16:20:34Z
dc.date.available.fl_str_mv 2016-04-14T16:20:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SAVINO, Wilson; et al. Laminin-Mediated Interactions in Thymocyte Migration and Development. Frontiers in Immunology, v.6, Article 579, 13p, Nov. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13776
dc.identifier.issn.none.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2015.00579
identifier_str_mv SAVINO, Wilson; et al. Laminin-Mediated Interactions in Thymocyte Migration and Development. Frontiers in Immunology, v.6, Article 579, 13p, Nov. 2015.
1664-3224
10.3389/fimmu.2015.00579
url https://www.arca.fiocruz.br/handle/icict/13776
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/13776/2/wilson3_savino_etl_IOC_2015.pdf
https://www.arca.fiocruz.br/bitstream/icict/13776/3/wilson3_savino_etl_IOC_2015.pdf.txt
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