Snake venom L-amino acid oxidases: an overview on their antitumor effects

Detalhes bibliográficos
Autor(a) principal: Costa,Tássia R
Data de Publicação: 2014
Outros Autores: Burin,Sandra M, Menaldo,Danilo L, Castro,Fabíola A de, Sampaio,Suely V
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200206
Resumo: The L-amino acid oxidases (LAAOs) constitute a major component of snake venoms and have been widely studied due to their widespread presence and various effects, such as apoptosis induction, cytotoxicity, induction and/or inhibition of platelet aggregation, hemorrhage, hemolysis, edema, as well as antimicrobial, antiparasitic and anti-HIV activities. The isolated and characterized snake venom LAAOs have become important research targets due to their potential biotechnological applications in pursuit for new drugs of interest in the scientific and medical fields. The current study discusses the antitumor effects of snake venom LAAOs described in the literature to date, highlighting the mechanisms of apoptosis induction proposed for this class of proteins.
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repository_id_str
spelling Snake venom L-amino acid oxidases: an overview on their antitumor effectsSnake venomsL-amino acid oxidasesAntitumor effectsApoptosisThe L-amino acid oxidases (LAAOs) constitute a major component of snake venoms and have been widely studied due to their widespread presence and various effects, such as apoptosis induction, cytotoxicity, induction and/or inhibition of platelet aggregation, hemorrhage, hemolysis, edema, as well as antimicrobial, antiparasitic and anti-HIV activities. The isolated and characterized snake venom LAAOs have become important research targets due to their potential biotechnological applications in pursuit for new drugs of interest in the scientific and medical fields. The current study discusses the antitumor effects of snake venom LAAOs described in the literature to date, highlighting the mechanisms of apoptosis induction proposed for this class of proteins.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200206Journal of Venomous Animals and Toxins including Tropical Diseases v.20 2014reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1186/1678-9199-20-23info:eu-repo/semantics/openAccessCosta,Tássia RBurin,Sandra MMenaldo,Danilo LCastro,Fabíola A deSampaio,Suely Veng2018-08-17T00:00:00Zoai:scielo:S1678-91992014000200206Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2018-08-17T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Snake venom L-amino acid oxidases: an overview on their antitumor effects
title Snake venom L-amino acid oxidases: an overview on their antitumor effects
spellingShingle Snake venom L-amino acid oxidases: an overview on their antitumor effects
Costa,Tássia R
Snake venoms
L-amino acid oxidases
Antitumor effects
Apoptosis
title_short Snake venom L-amino acid oxidases: an overview on their antitumor effects
title_full Snake venom L-amino acid oxidases: an overview on their antitumor effects
title_fullStr Snake venom L-amino acid oxidases: an overview on their antitumor effects
title_full_unstemmed Snake venom L-amino acid oxidases: an overview on their antitumor effects
title_sort Snake venom L-amino acid oxidases: an overview on their antitumor effects
author Costa,Tássia R
author_facet Costa,Tássia R
Burin,Sandra M
Menaldo,Danilo L
Castro,Fabíola A de
Sampaio,Suely V
author_role author
author2 Burin,Sandra M
Menaldo,Danilo L
Castro,Fabíola A de
Sampaio,Suely V
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Costa,Tássia R
Burin,Sandra M
Menaldo,Danilo L
Castro,Fabíola A de
Sampaio,Suely V
dc.subject.por.fl_str_mv Snake venoms
L-amino acid oxidases
Antitumor effects
Apoptosis
topic Snake venoms
L-amino acid oxidases
Antitumor effects
Apoptosis
description The L-amino acid oxidases (LAAOs) constitute a major component of snake venoms and have been widely studied due to their widespread presence and various effects, such as apoptosis induction, cytotoxicity, induction and/or inhibition of platelet aggregation, hemorrhage, hemolysis, edema, as well as antimicrobial, antiparasitic and anti-HIV activities. The isolated and characterized snake venom LAAOs have become important research targets due to their potential biotechnological applications in pursuit for new drugs of interest in the scientific and medical fields. The current study discusses the antitumor effects of snake venom LAAOs described in the literature to date, highlighting the mechanisms of apoptosis induction proposed for this class of proteins.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200206
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200206
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1186/1678-9199-20-23
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.20 2014
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
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