Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19673 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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Souza, Wayner Vieira deAraújo, Thália Velho Barreto deAlbuquerque, Maria de Fátima Pessoa Militão deBraga, Maria CynthiaXimenes, Ricardo Arraes de AlencarMiranda-Filho, Demócrito de BarrosBezerra, Luciana Caroline AlbuquerqueDimech, George SantiagoCarvalho, Patrícia Ismael deAssunção, Romildo Siqueira deSantos, Roselene HansOliveira, Wanderson Kleber deRodrigues, Laura CunhaMartelli, Celina Maria Turchi2017-06-29T15:38:04Z2017-06-29T15:38:04Z2016SOUZA, Wayner Vieira de et al. Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases. Cadernos de Saúde Pública, v. 32, n. 4, p. 1-7, 2016.1678-4464https://www.arca.fiocruz.br/handle/icict/1967310.1590/0102-311X00017216porMicrocefaliaBrasilZika virusEpidemiologiaBrazilFemaleGestational AgeHumansInfant NewbornMaleMicrocephalyPregnancyPregnancy Complications, InfectiousROC CurveSensitivity and SpecificityZika virusZika Virus InfectionEpidemiologyZika virusSensibilidade e EspecificidadeInfecção pelo Zika virusHumanosMasculinoGravidezComplicações Infecciosas na GravidezCurva ROCMicrocefaliaRecém-NascidoFemininoIdade GestacionalEpidemiologiaDiagnósticoMicrocephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected casesMicrocefalia no Estado de Pernambuco, Brasil: características epidemiológicas e avaliação da acurácia diagnóstica dos pontos de corte adotados para notificação de casoMicrocefalia en el estado de Pernambuco, Brasil: características epidemiológicas y evaluación de la precisión diagnóstica de los puntos de corte adoptados para la notificación de casosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, BrasilThe increase in the number of reported cases of microcephaly in Pernambuco State, and Northeast Brazil, characterized an epidemic that led the Brazilian Ministry of Health to declare a national public health emergency. The Brazilian Ministry of Health initially defined suspected cases as newborns with gestational age (GA) ≥ 37 weeks and head circumference (HC) ≤ 33cm, but in December 2015 this cutoff was lowered to 32cm. The current study aimed to estimate the accuracy, sensitivity, and specificity of different cutoff points for HC, using ROC curves, with the Fenton and Intergrowth (2014) curves as the gold standard. The study described cases reported in Pernambuco from August 8 to November 28, 2015, according to sex and GA categories. The Fenton and Intergrowth methods provide HC growth curves according to GA and sex, and microcephaly is defined as a newborn with HC below the 3rd percentile in these distributions. Of the 684 reported cases, 599 were term or post-term neonates. For these, the analyses with ROC curves show that according to the Fenton criterion the cutoff point with the largest area under the ROC curve, with sensitivity greater than specificity, is 32cm for both sexes. Using the Intergrowth method and following the same criteria, the cutoff points are 32cm and 31.5cm for males and females, respectively. The cutoff point identified by the Fenton method (32cm) coincided with the Brazilian Ministry of Health recommendation. Adopting Intergrowth as the standard, the choice would be 32cm for males and 31.5cm for females. The study identified the need to conduct critical and on-going analyses to evaluate cutoff points, including other characteristics for microcephaly case definition.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19673/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL27143306 2017 sou-mic.en.oa.pdf27143306 2017 sou-mic.en.oa.pdfEnglish versionapplication/pdf176214https://www.arca.fiocruz.br/bitstream/icict/19673/2/27143306%202017%20sou-mic.en.oa.pdfd12a30aeef81ddd4d43b389a968b0bccMD5227143306 2017 sou-mic.sp.oa.pdf27143306 2017 sou-mic.sp.oa.pdfVersion en españolapplication/pdf182981https://www.arca.fiocruz.br/bitstream/icict/19673/3/27143306%202017%20sou-mic.sp.oa.pdfea20730be60841ec61e0b61bf3516a0aMD5327143306 2017 sou-mic.pt.oa.pdf27143306 2017 sou-mic.pt.oa.pdfVersão em 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| dc.title.pt_BR.fl_str_mv |
Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases |
| dc.title.alternative.pt_BR.fl_str_mv |
Microcefalia no Estado de Pernambuco, Brasil: características epidemiológicas e avaliação da acurácia diagnóstica dos pontos de corte adotados para notificação de caso Microcefalia en el estado de Pernambuco, Brasil: características epidemiológicas y evaluación de la precisión diagnóstica de los puntos de corte adoptados para la notificación de casos |
| title |
Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases |
| spellingShingle |
Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases Souza, Wayner Vieira de Microcefalia Brasil Zika virus Epidemiologia Brazil Female Gestational Age Humans Infant Newborn Male Microcephaly Pregnancy Pregnancy Complications, Infectious ROC Curve Sensitivity and Specificity Zika virus Zika Virus Infection Epidemiology Zika virus Sensibilidade e Especificidade Infecção pelo Zika virus Humanos Masculino Gravidez Complicações Infecciosas na Gravidez Curva ROC Microcefalia Recém-Nascido Feminino Idade Gestacional Epidemiologia Diagnóstico |
| title_short |
Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases |
| title_full |
Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases |
| title_fullStr |
Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases |
| title_full_unstemmed |
Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases |
| title_sort |
Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases |
| author |
Souza, Wayner Vieira de |
| author_facet |
Souza, Wayner Vieira de Araújo, Thália Velho Barreto de Albuquerque, Maria de Fátima Pessoa Militão de Braga, Maria Cynthia Ximenes, Ricardo Arraes de Alencar Miranda-Filho, Demócrito de Barros Bezerra, Luciana Caroline Albuquerque Dimech, George Santiago Carvalho, Patrícia Ismael de Assunção, Romildo Siqueira de Santos, Roselene Hans Oliveira, Wanderson Kleber de Rodrigues, Laura Cunha Martelli, Celina Maria Turchi |
| author_role |
author |
| author2 |
Araújo, Thália Velho Barreto de Albuquerque, Maria de Fátima Pessoa Militão de Braga, Maria Cynthia Ximenes, Ricardo Arraes de Alencar Miranda-Filho, Demócrito de Barros Bezerra, Luciana Caroline Albuquerque Dimech, George Santiago Carvalho, Patrícia Ismael de Assunção, Romildo Siqueira de Santos, Roselene Hans Oliveira, Wanderson Kleber de Rodrigues, Laura Cunha Martelli, Celina Maria Turchi |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Wayner Vieira de Araújo, Thália Velho Barreto de Albuquerque, Maria de Fátima Pessoa Militão de Braga, Maria Cynthia Ximenes, Ricardo Arraes de Alencar Miranda-Filho, Demócrito de Barros Bezerra, Luciana Caroline Albuquerque Dimech, George Santiago Carvalho, Patrícia Ismael de Assunção, Romildo Siqueira de Santos, Roselene Hans Oliveira, Wanderson Kleber de Rodrigues, Laura Cunha Martelli, Celina Maria Turchi |
| dc.subject.other.pt_BR.fl_str_mv |
Microcefalia Brasil Zika virus Epidemiologia |
| topic |
Microcefalia Brasil Zika virus Epidemiologia Brazil Female Gestational Age Humans Infant Newborn Male Microcephaly Pregnancy Pregnancy Complications, Infectious ROC Curve Sensitivity and Specificity Zika virus Zika Virus Infection Epidemiology Zika virus Sensibilidade e Especificidade Infecção pelo Zika virus Humanos Masculino Gravidez Complicações Infecciosas na Gravidez Curva ROC Microcefalia Recém-Nascido Feminino Idade Gestacional Epidemiologia Diagnóstico |
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Brazil Female Gestational Age Humans Infant Newborn Male Microcephaly Pregnancy Pregnancy Complications, Infectious ROC Curve Sensitivity and Specificity Zika virus Zika Virus Infection Epidemiology |
| dc.subject.decs.pt_BR.fl_str_mv |
Zika virus Sensibilidade e Especificidade Infecção pelo Zika virus Humanos Masculino Gravidez Complicações Infecciosas na Gravidez Curva ROC Microcefalia Recém-Nascido Feminino Idade Gestacional Epidemiologia Diagnóstico |
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Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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2016 |
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2016 |
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2017-06-29T15:38:04Z |
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2017-06-29T15:38:04Z |
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info:eu-repo/semantics/article |
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SOUZA, Wayner Vieira de et al. Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases. Cadernos de Saúde Pública, v. 32, n. 4, p. 1-7, 2016. |
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https://www.arca.fiocruz.br/handle/icict/19673 |
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1678-4464 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/0102-311X00017216 |
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SOUZA, Wayner Vieira de et al. Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases. Cadernos de Saúde Pública, v. 32, n. 4, p. 1-7, 2016. 1678-4464 10.1590/0102-311X00017216 |
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