Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10214 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada em Micobactérias . Rio de Janeiro, RJ, Brasil. |
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Spinasse, Lizania BorgesSantos, Adalberto RezendeSuffys, Philip NoelMuxfeldt, Elizabeth SilaidSalles, Gil Fernando2015-05-04T17:07:32Z2015-05-04T17:07:32Z2014SPINASSE, Lizania Borges et al. Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension. Pharmacogenomics, v.15, n.2, p.169-178, 2014.1462-2416https://www.arca.fiocruz.br/handle/icict/1021410.2217/pgs.13.202engFuture Medicine LtdHidralazinaHipertensãoBrasilPopulaçãoBrazilian populationHydralazineNAT2 polymorphismResistant hypertensionSNPHidralazinaHipertensiónBrasilPoblaciónCiências BiológicasHidralazinaDifferent phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertensioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada em Micobactérias . Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada em Micobactérias . Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada em Micobactérias . Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Escola de Medicina. Hospital Universitário Clementino Fraga Filho. Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Escola de Medicina. Hospital Universitário Clementino Fraga Filho. Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.Aim: Hydralazine, a vasodilator used in resistant hypertension (RH) treatment is metabolized by an acetylation reaction mediated by N-acetyltransferase 2, the activity of which depends on NAT2 polymorphisms. Our aim was to evaluate whether different acetylation phenotypes influenced the antihypertensive effect of hydralazine in patients with RH. Patients & methods: DNA samples from 169 RH patients using hydralazine were genotyped by sequencing the NAT2 coding region, and acetylation phenotypes were defined. Results: Sixty-five patients (38.5%) were intermediate, 60 (35.5%) slow and 21 (12.4%) fast acetylators. Twenty-three (13.6%) patients were indeterminate. Upon association analysis, only slow acetylators had significant blood pressure reductions after hydralazine use, with mean 24-h systolic and diastolic blood pressure reductions of 9.2 and 5.5 mmHg. Four patients presented hydralazine adverse effects resulting in drug withdrawal, three of them were slow acetylators. Conclusion: The slow acetylation phenotype, determined by polymorphisms within NAT2, influenced both the antihypertensive and adverse effects of hydralazine in RH.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10214/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALlizania_spinasseetal_IOC_2014.pdfapplication/pdf620795https://www.arca.fiocruz.br/bitstream/icict/10214/2/lizania_spinasseetal_IOC_2014.pdf961ba6b951f8b8cc018ff2887446ad00MD52TEXTlizania_spinasseetal_IOC_2014.pdf.txtlizania_spinasseetal_IOC_2014.pdf.txtExtracted texttext/plain40516https://www.arca.fiocruz.br/bitstream/icict/10214/3/lizania_spinasseetal_IOC_2014.pdf.txt927b7874a5dc886e05259927e9d41707MD53icict/102142022-06-24 13:11:03.796oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:11:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension |
| title |
Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension |
| spellingShingle |
Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension Spinasse, Lizania Borges Hidralazina Hipertensão Brasil População Brazilian population Hydralazine NAT2 polymorphism Resistant hypertension SNP Hidralazina Hipertensión Brasil Población Ciências Biológicas Hidralazina |
| title_short |
Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension |
| title_full |
Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension |
| title_fullStr |
Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension |
| title_full_unstemmed |
Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension |
| title_sort |
Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension |
| author |
Spinasse, Lizania Borges |
| author_facet |
Spinasse, Lizania Borges Santos, Adalberto Rezende Suffys, Philip Noel Muxfeldt, Elizabeth Silaid Salles, Gil Fernando |
| author_role |
author |
| author2 |
Santos, Adalberto Rezende Suffys, Philip Noel Muxfeldt, Elizabeth Silaid Salles, Gil Fernando |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Spinasse, Lizania Borges Santos, Adalberto Rezende Suffys, Philip Noel Muxfeldt, Elizabeth Silaid Salles, Gil Fernando |
| dc.subject.other.pt_BR.fl_str_mv |
Hidralazina Hipertensão Brasil População |
| topic |
Hidralazina Hipertensão Brasil População Brazilian population Hydralazine NAT2 polymorphism Resistant hypertension SNP Hidralazina Hipertensión Brasil Población Ciências Biológicas Hidralazina |
| dc.subject.en.pt_BR.fl_str_mv |
Brazilian population Hydralazine NAT2 polymorphism Resistant hypertension SNP |
| dc.subject.es.pt_BR.fl_str_mv |
Hidralazina Hipertensión Brasil Población |
| dc.subject.decs.pt_BR.fl_str_mv |
Ciências Biológicas Hidralazina |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada em Micobactérias . Rio de Janeiro, RJ, Brasil. |
| publishDate |
2014 |
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2014 |
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2015-05-04T17:07:32Z |
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2015-05-04T17:07:32Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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SPINASSE, Lizania Borges et al. Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension. Pharmacogenomics, v.15, n.2, p.169-178, 2014. |
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https://www.arca.fiocruz.br/handle/icict/10214 |
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1462-2416 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.2217/pgs.13.202 |
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SPINASSE, Lizania Borges et al. Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension. Pharmacogenomics, v.15, n.2, p.169-178, 2014. 1462-2416 10.2217/pgs.13.202 |
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Future Medicine Ltd |
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Future Medicine Ltd |
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