Carvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46080 |
Resumo: | Brazilian National Council of Research (CNPq), the Coordination for the Improvement of Higher Education Personnel (CAPES) and the Oswaldo Cruz Foundation (FIOCRUZ). |
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Ribeiro Filho, JaimeBrandi, Juliana da SilvaCosta, Hermann FerreiraMedeiros, Karina Carla de PaulaLeite, Jacqueline AlvesSousa, Damião Pergentino dePiuvezam, Márcia Regina2021-02-14T12:43:20Z2021-02-14T12:43:20Z2020RIBEIRO FILHO, Jaime et al. Carvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Mice. International Journal of Molecular Sciences, p. 1-16, 2020.1661-6596https://www.arca.fiocruz.br/handle/icict/4608010.3390/ijms21239209Brazilian National Council of Research (CNPq), the Coordination for the Improvement of Higher Education Personnel (CAPES) and the Oswaldo Cruz Foundation (FIOCRUZ).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Unifaminas Centro Universitário. Centro de Ciências da Saúde. Departamento de Farmácia. Muriaé, MG, Brasil.Faculdade de Medicina Nova Esperança. João Pessoa, PB, Brasil.Universidade Federal do Rio Grande do Norte. Centro de Biociências. Departamento de Morfologia. Natal, RN, Brasil.Universidade de Goiás. Instituto de Ciências Biológicas, Departamento de Farmacologia. Goiânia, GO, Brasil.Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. João Pessoa, PB, Brasil.Universidade federal da Paraíba. Laboratório de Imunofarmacologia. Departamento de Fisiologia e Patologia. João Pessoa, PB, Brasil.Carvone is a monoterpene found in nature in the form of enantiomers (S- and R-). While previous research has demonstrated the anti-inflammatory and anti-allergic effects of carvone, the influence of carvone enantiomeric composition on its anti-allergic activity remains to be investigated. This study aimed to evaluate the anti-allergic activity of carvone enantiomers in a murine model of airway allergic inflammation induced by sensitization and challenge with ovalbumin (OVA). The oral treatment with R-carvone or S-carvone 1 h before each challenge inhibited the number of leukocytes and eosinophils in the bronchoalveolar lavage (BAL). R-carvone inhibited leukocyte infiltration and mucus production in the lung, which was correlated with decreased production of OVA-specific IgE in the serum and increased concentrations of IL-10 in the BAL. On the other hand, the administration of S-carvone had little inhibitory effect on inflammatory infiltration and mucus production in the lung, which might be associated with increased production of IFN- in the BAL.When administered 1 h before each sensitization, both enantiomers inhibited eosinophil recruitment to the BAL but failed in decreasing the titers of IgE in the serum of allergic mice. Our data indicate that carvone enantiomers differentially modulated IgE-mediated airway inflammation in mice. In conclusion, unlike S-carvone, R-carvone has the potential to be used in anti-allergic drug development.engMDPIInflamaçãoEosinófilosCamondongosLavagem BroncoalveolarAntialérgicosCarvoneEnantiomersAirway inflammationEosinophilsAnti-allergicTerpenesCarvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46080/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALRIBEIRO-FILHO et al Carvone enantiomers differentially...2020 v.21 pg.1-16.pdfRIBEIRO-FILHO et al Carvone enantiomers differentially...2020 v.21 pg.1-16.pdfapplication/pdf2483484https://www.arca.fiocruz.br/bitstream/icict/46080/2/RIBEIRO-FILHO%20et%20al%20Carvone%20enantiomers%20differentially...2020%20v.21%20pg.1-16.pdf9aaa42982be45ce56a374cc2db855e6cMD52TEXTRIBEIRO-FILHO et al Carvone enantiomers differentially...2020 v.21 pg.1-16.pdf.txtRIBEIRO-FILHO et al Carvone enantiomers differentially...2020 v.21 pg.1-16.pdf.txtExtracted texttext/plain68487https://www.arca.fiocruz.br/bitstream/icict/46080/3/RIBEIRO-FILHO%20et%20al%20Carvone%20enantiomers%20differentially...2020%20v.21%20pg.1-16.pdf.txt6dc83b014a86b694b9b680661ea7393cMD53icict/460802023-03-15 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| dc.title.pt_BR.fl_str_mv |
Carvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Mice |
| title |
Carvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Mice |
| spellingShingle |
Carvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Mice Ribeiro Filho, Jaime Inflamação Eosinófilos Camondongos Lavagem Broncoalveolar Antialérgicos Carvone Enantiomers Airway inflammation Eosinophils Anti-allergic Terpenes |
| title_short |
Carvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Mice |
| title_full |
Carvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Mice |
| title_fullStr |
Carvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Mice |
| title_full_unstemmed |
Carvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Mice |
| title_sort |
Carvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Mice |
| author |
Ribeiro Filho, Jaime |
| author_facet |
Ribeiro Filho, Jaime Brandi, Juliana da Silva Costa, Hermann Ferreira Medeiros, Karina Carla de Paula Leite, Jacqueline Alves Sousa, Damião Pergentino de Piuvezam, Márcia Regina |
| author_role |
author |
| author2 |
Brandi, Juliana da Silva Costa, Hermann Ferreira Medeiros, Karina Carla de Paula Leite, Jacqueline Alves Sousa, Damião Pergentino de Piuvezam, Márcia Regina |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Ribeiro Filho, Jaime Brandi, Juliana da Silva Costa, Hermann Ferreira Medeiros, Karina Carla de Paula Leite, Jacqueline Alves Sousa, Damião Pergentino de Piuvezam, Márcia Regina |
| dc.subject.other.pt_BR.fl_str_mv |
Inflamação Eosinófilos Camondongos Lavagem Broncoalveolar Antialérgicos |
| topic |
Inflamação Eosinófilos Camondongos Lavagem Broncoalveolar Antialérgicos Carvone Enantiomers Airway inflammation Eosinophils Anti-allergic Terpenes |
| dc.subject.en.pt_BR.fl_str_mv |
Carvone Enantiomers Airway inflammation Eosinophils Anti-allergic Terpenes |
| description |
Brazilian National Council of Research (CNPq), the Coordination for the Improvement of Higher Education Personnel (CAPES) and the Oswaldo Cruz Foundation (FIOCRUZ). |
| publishDate |
2020 |
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2020 |
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2021-02-14T12:43:20Z |
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2021-02-14T12:43:20Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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RIBEIRO FILHO, Jaime et al. Carvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Mice. International Journal of Molecular Sciences, p. 1-16, 2020. |
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https://www.arca.fiocruz.br/handle/icict/46080 |
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1661-6596 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/ijms21239209 |
| identifier_str_mv |
RIBEIRO FILHO, Jaime et al. Carvone Enantiomers Di erentially Modulate IgE-Mediated Airway Inflammation in Mice. International Journal of Molecular Sciences, p. 1-16, 2020. 1661-6596 10.3390/ijms21239209 |
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https://www.arca.fiocruz.br/handle/icict/46080 |
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eng |
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