Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection

Detalhes bibliográficos
Autor(a) principal: Bastos, M. L.
Data de Publicação: 2013
Outros Autores: Menzies, D., Belo, M. T. C. T., Teixeira, E. G., Abreu, S. T. de, Antas, P. R. Z., Trajman, A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11789
Resumo: Universidade Gama Filho. Escola de Medicina. Programa de Pós-Gradução em Educação em Saúde. Rio de Janeiro, RJ, Brasil / Liga Científica de Tuberculose do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
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spelling Bastos, M. L.Menzies, D.Belo, M. T. C. T.Teixeira, E. G.Abreu, S. T. deAntas, P. R. Z.Trajman, A.2015-09-21T17:25:49Z2015-09-21T17:25:49Z2013BASTOS, M. L.; et al. Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection. The International Journal of Tuberculosis and Lung Disease, v.17, n.7, p.909-918, 2013.https://www.arca.fiocruz.br/handle/icict/1178910.5588/ijtld.12.0927engThe UnionChanges in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Gama Filho. Escola de Medicina. Programa de Pós-Gradução em Educação em Saúde. Rio de Janeiro, RJ, Brasil / Liga Científica de Tuberculose do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.McGill University. Montreal Chest Institute. Respiratory Epidemiology and Clinical Research Unit. Montreal, Quebec, Canada.Universidade Gama Filho. Escola de Medicina. Programa de Pós-Gradução em Educação em Saúde. Rio de Janeiro, RJ, Brasil / Liga Científica de Tuberculose do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Fundação Souza Marques. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Universidade Gama Filho. Escola de Medicina. Programa de Pós-Gradução em Educação em Saúde. Rio de Janeiro, RJ, Brasil / Liga Científica de Tuberculose do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Fundação Souza Marques. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Laboratório Pascoal Granato. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.Universidade Gama Filho. Escola de Medicina. Programa de Pós-Gradução em Educação em Saúde. Rio de Janeiro, RJ, Brasil / Liga Científica de Tuberculose do Rio de Janeiro. Rio de Janeiro, RJ, Brasil /McGill University. Montreal Chest Institute. Respiratory Epidemiology and Clinical Research Unit. Montreal, Quebec, Canada.SETTING: Randomised trial comparing 9 months of isoniazid with 4 months of rifampicin for the treatment of high-risk tuberculin skin test positive subjects in Rio de Janeiro, Brazil. OBJECTIVES: To compare QuantiFERON®-TB Gold In- Tube (QFT-GIT) responses before and 1, 4 and 9 months after starting treatment for latent tuberculous infection (LTBI) according to adherence to one of the two regimens. DESIGN: Participants in the trial were invited to undergo serial QFT-GIT. Within-subject differences at different time points were analysed as quantitative responses and categorised as positive or negative using different cut-off points. RESULTS: Of 215 participants, 118 completed treatment, of whom 58 underwent all three tests; and 97 did not complete treatment, of whom 10 underwent all tests. After 1 month of treatment, there was no significant difference in QFT-GIT response between the groups. After 4 and 9 months, reversions were more frequent in nonadherent subjects. Marked within-subject fluctuations were observed. No cut-off point could be established at which QFT-GIT responses were consistently positive or associated with adherence or type of treatment. CONCLUSION: Frequent within-subject variability in QFT-GIT responses, not associated with LTBI treatment, makes it difficult for clinicians to interpret QFT-GIT conversions and reversions.BiomarkerInterferon-gamma assaySerial testingLatent tuberculosisTuberculoseInterferon gamaTuberculose Latenteinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11789/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALprz_antas_etal_IOC_2013.pdfapplication/pdf318292https://www.arca.fiocruz.br/bitstream/icict/11789/2/prz_antas_etal_IOC_2013.pdf7ed9c362936379698f55d848fd3daf40MD52TEXTprz_antas_etal_IOC_2013.pdf.txtprz_antas_etal_IOC_2013.pdf.txtExtracted texttext/plain40899https://www.arca.fiocruz.br/bitstream/icict/11789/3/prz_antas_etal_IOC_2013.pdf.txtc70152503ecfd86c39aeb18e9c7ec631MD53icict/117892022-06-24 12:17:38.296oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:17:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
title Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
spellingShingle Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
Bastos, M. L.
Biomarker
Interferon-gamma assay
Serial testing
Latent tuberculosis
Tuberculose
Interferon gama
Tuberculose Latente
title_short Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
title_full Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
title_fullStr Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
title_full_unstemmed Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
title_sort Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
author Bastos, M. L.
author_facet Bastos, M. L.
Menzies, D.
Belo, M. T. C. T.
Teixeira, E. G.
Abreu, S. T. de
Antas, P. R. Z.
Trajman, A.
author_role author
author2 Menzies, D.
Belo, M. T. C. T.
Teixeira, E. G.
Abreu, S. T. de
Antas, P. R. Z.
Trajman, A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bastos, M. L.
Menzies, D.
Belo, M. T. C. T.
Teixeira, E. G.
Abreu, S. T. de
Antas, P. R. Z.
Trajman, A.
dc.subject.en.pt_BR.fl_str_mv Biomarker
Interferon-gamma assay
Serial testing
Latent tuberculosis
topic Biomarker
Interferon-gamma assay
Serial testing
Latent tuberculosis
Tuberculose
Interferon gama
Tuberculose Latente
dc.subject.decs.pt_BR.fl_str_mv Tuberculose
Interferon gama
Tuberculose Latente
description Universidade Gama Filho. Escola de Medicina. Programa de Pós-Gradução em Educação em Saúde. Rio de Janeiro, RJ, Brasil / Liga Científica de Tuberculose do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2015-09-21T17:25:49Z
dc.date.available.fl_str_mv 2015-09-21T17:25:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BASTOS, M. L.; et al. Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection. The International Journal of Tuberculosis and Lung Disease, v.17, n.7, p.909-918, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11789
dc.identifier.doi.pt_BR.fl_str_mv 10.5588/ijtld.12.0927
identifier_str_mv BASTOS, M. L.; et al. Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection. The International Journal of Tuberculosis and Lung Disease, v.17, n.7, p.909-918, 2013.
10.5588/ijtld.12.0927
url https://www.arca.fiocruz.br/handle/icict/11789
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv The Union
publisher.none.fl_str_mv The Union
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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