Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy

Detalhes bibliográficos
Autor(a) principal: Moranguinho, Inês
Data de Publicação: 2019
Outros Autores: Borrego, Pedro, Gonçalves, Fátima, Gomes, Perpétua, Rocha, José, Barreto, Jorge, Taveira, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/30476
Resumo: The pol gene from HIV-2 infected patients from Cape Verde experiencing virologic failure was sequenced and drug resistance mutations were determined. Most patients were taking a first line regimen of AZT, 3TC and LPV/r. Resistance mutations were found in most patients (11/17, 64.7%) especially I82F (4/7, 57.1%) and M184 V (10/17, 58.8%). Resistance to all reverse transcriptase and protease inhibitors was found in 58.8% (10/17) of the patients. Integrase inhibitors are warranted to treat these patients.
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spelling Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapyHIV-2 infected patientsGenotypic resistance profilesCape VerdeAntiretroviral therapyThe pol gene from HIV-2 infected patients from Cape Verde experiencing virologic failure was sequenced and drug resistance mutations were determined. Most patients were taking a first line regimen of AZT, 3TC and LPV/r. Resistance mutations were found in most patients (11/17, 64.7%) especially I82F (4/7, 57.1%) and M184 V (10/17, 58.8%). Resistance to all reverse transcriptase and protease inhibitors was found in 58.8% (10/17) of the patients. Integrase inhibitors are warranted to treat these patients.Wolters KluwerRepositório ComumMoranguinho, InêsBorrego, PedroGonçalves, FátimaGomes, PerpétuaRocha, JoséBarreto, JorgeTaveira, Nuno2021-12-31T01:30:22Z2019-11-01T00:00:00Z2019-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/30476engAIDS: November 14, 2019 - Volume Publish Ahead of Print. doi: 10.1097/QAD.00000000000024310269-937010.1097/QAD.0000000000002431info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:52Zoai:comum.rcaap.pt:10400.26/30476Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:38.270725Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
title Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
spellingShingle Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
Moranguinho, Inês
HIV-2 infected patients
Genotypic resistance profiles
Cape Verde
Antiretroviral therapy
title_short Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
title_full Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
title_fullStr Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
title_full_unstemmed Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
title_sort Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
author Moranguinho, Inês
author_facet Moranguinho, Inês
Borrego, Pedro
Gonçalves, Fátima
Gomes, Perpétua
Rocha, José
Barreto, Jorge
Taveira, Nuno
author_role author
author2 Borrego, Pedro
Gonçalves, Fátima
Gomes, Perpétua
Rocha, José
Barreto, Jorge
Taveira, Nuno
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Moranguinho, Inês
Borrego, Pedro
Gonçalves, Fátima
Gomes, Perpétua
Rocha, José
Barreto, Jorge
Taveira, Nuno
dc.subject.por.fl_str_mv HIV-2 infected patients
Genotypic resistance profiles
Cape Verde
Antiretroviral therapy
topic HIV-2 infected patients
Genotypic resistance profiles
Cape Verde
Antiretroviral therapy
description The pol gene from HIV-2 infected patients from Cape Verde experiencing virologic failure was sequenced and drug resistance mutations were determined. Most patients were taking a first line regimen of AZT, 3TC and LPV/r. Resistance mutations were found in most patients (11/17, 64.7%) especially I82F (4/7, 57.1%) and M184 V (10/17, 58.8%). Resistance to all reverse transcriptase and protease inhibitors was found in 58.8% (10/17) of the patients. Integrase inhibitors are warranted to treat these patients.
publishDate 2019
dc.date.none.fl_str_mv 2019-11-01T00:00:00Z
2019-11-01T00:00:00Z
2021-12-31T01:30:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/30476
url http://hdl.handle.net/10400.26/30476
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv AIDS: November 14, 2019 - Volume Publish Ahead of Print. doi: 10.1097/QAD.0000000000002431
0269-9370
10.1097/QAD.0000000000002431
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer
publisher.none.fl_str_mv Wolters Kluwer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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