One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12807 |
Resumo: | Fundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil |
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Pereira, Christiane CostaMoreira, Marcela de LimaSoares, Rodrigo Pedro PintoMarteleto, Bruno HenriqueRibeiro, Vitor MarcioDias, Michelle Hallais FrançaCardoso, Ludmila MeloViana, Kelvinson FernandesGiunchetti, Rodolfo CordeiroMartins Filho, Olindo AssisAraújo, Márcio Sobreira Silva2016-02-25T16:55:09Z2016-02-25T16:55:09Z2015PEREIRA, Christiane Costa et al. One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis. BMC Vet Res., vol., 11, p. 92, 2015.1746-6148https://www.arca.fiocruz.br/handle/icict/1280710.1186/s12917-015-0397-6.engBioMed CentralOne-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilClínica Veterinária Santo Agostinho. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilBACKGROUND: The main control strategy for visceral leishmaniasis in Brazil has been based on the elimination of seropositive dogs, although this is not widely accepted. In this context, the use of a long-lasting protective vaccine against canine visceral leishmaniasis (CVL) has been highly expected. The aim of this work was to determine the timeline kinetics of the cytokine microenvironment derived from circulating leukocytes as supportive immunological biomarkers triggered by Leishmune® vaccine. Cross-sectional kinetic analysis of cellular immunity cytokines was carried out at three times (1, 6 and 12 months) after primovaccination with Leishmune®. In vitro short-term whole blood cultures were stimulated with Leishmania infantum soluble antigen (SLAg). The secreted cytokine signatures and their major sources were determined. RESULTS: At six months after vaccination, Leishmune® induced an increase in IL-8, IFN-γ, IL-17a and TNF-α levels and a decrease in IL-10. Cytokine signature analysis revealed a shift in the microenvironment towards a pro-inflammatory profile mediated by IL-8 and IFN-γ. Both, CD4(+) (↑TNF-α(+) and ↑IFN-γ (+)) and CD8(+) (↑IL-17a and ↓IL-4) T-cells contributed to the acquired immune responses observed after stimulation with SLAg. CONCLUSIONS: The changes observed in the cytokine profile suggested that Leishmune® was able to induce an effective response at six months after primovaccination. After one year, it returned to baseline suggesting the need of additional boosting.Canine visceral leishmaniasisVaccine, Leishmune®Cytokinesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12807/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOne-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis.pdfOne-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis.pdfapplication/pdf6782061https://www.arca.fiocruz.br/bitstream/icict/12807/2/One-year%20timeline%20kinetics%20of%20cytokine-mediated%20cellular%20immunity%20in%20dogs%20vaccinated%20against%20visceral%20leishmaniasis.pdf77ecaad1e183d9a9a0d6c2c8d9d5bc69MD52TEXTOne-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis.pdf.txtOne-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis.pdf.txtExtracted texttext/plain671https://www.arca.fiocruz.br/bitstream/icict/12807/3/One-year%20timeline%20kinetics%20of%20cytokine-mediated%20cellular%20immunity%20in%20dogs%20vaccinated%20against%20visceral%20leishmaniasis.pdf.txt8b57ae4697fe443ff95df68ffd3448aaMD53icict/128072022-02-02 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dc.title.pt_BR.fl_str_mv |
One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis |
title |
One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis |
spellingShingle |
One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis Pereira, Christiane Costa Canine visceral leishmaniasis Vaccine, Leishmune® Cytokines |
title_short |
One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis |
title_full |
One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis |
title_fullStr |
One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis |
title_full_unstemmed |
One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis |
title_sort |
One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis |
author |
Pereira, Christiane Costa |
author_facet |
Pereira, Christiane Costa Moreira, Marcela de Lima Soares, Rodrigo Pedro Pinto Marteleto, Bruno Henrique Ribeiro, Vitor Marcio Dias, Michelle Hallais França Cardoso, Ludmila Melo Viana, Kelvinson Fernandes Giunchetti, Rodolfo Cordeiro Martins Filho, Olindo Assis Araújo, Márcio Sobreira Silva |
author_role |
author |
author2 |
Moreira, Marcela de Lima Soares, Rodrigo Pedro Pinto Marteleto, Bruno Henrique Ribeiro, Vitor Marcio Dias, Michelle Hallais França Cardoso, Ludmila Melo Viana, Kelvinson Fernandes Giunchetti, Rodolfo Cordeiro Martins Filho, Olindo Assis Araújo, Márcio Sobreira Silva |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira, Christiane Costa Moreira, Marcela de Lima Soares, Rodrigo Pedro Pinto Marteleto, Bruno Henrique Ribeiro, Vitor Marcio Dias, Michelle Hallais França Cardoso, Ludmila Melo Viana, Kelvinson Fernandes Giunchetti, Rodolfo Cordeiro Martins Filho, Olindo Assis Araújo, Márcio Sobreira Silva |
dc.subject.en.pt_BR.fl_str_mv |
Canine visceral leishmaniasis Vaccine, Leishmune® Cytokines |
topic |
Canine visceral leishmaniasis Vaccine, Leishmune® Cytokines |
description |
Fundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2016-02-25T16:55:09Z |
dc.date.available.fl_str_mv |
2016-02-25T16:55:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PEREIRA, Christiane Costa et al. One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis. BMC Vet Res., vol., 11, p. 92, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/12807 |
dc.identifier.issn.none.fl_str_mv |
1746-6148 |
dc.identifier.doi.none.fl_str_mv |
10.1186/s12917-015-0397-6. |
identifier_str_mv |
PEREIRA, Christiane Costa et al. One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis. BMC Vet Res., vol., 11, p. 92, 2015. 1746-6148 10.1186/s12917-015-0397-6. |
url |
https://www.arca.fiocruz.br/handle/icict/12807 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
BioMed Central |
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BioMed Central |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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