Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1126/science.1233665 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12579 |
Resumo: | University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA. |
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Teles, Rosane M. B.Graeber, Thomas G.Krutzik, Stephan R.Montoya, DennisSchenk, MirjamLee, Delphine J.Komisopoulou, EvangeliaKelly-Scumpia, KindraChun, ReneIyer, Shankar S.Sarno, Euzenir NunesRea, Thomas H.Hewison, MartinAdams, John S.Popper, Stephen J.Relman, David A.Stenger, SteffenBloom, Barry R.Cheng, GenhongModlin, Robert L.2016-01-21T14:06:52Z2016-01-21T14:06:52Z2013TELES, Rosane M. B. et al. Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses. Science, v.339, p.1448-1453, March 2013.1095-9203https://www.arca.fiocruz.br/handle/icict/1257910.1126/science.1233665engAmerican Association for the Advancement of ScienceType I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responsesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA.University of California. Department of Molecular and Medical Pharmacology. California NanoSystems Institute. Johnson Comprehensive Cancer Center. Institute for Molecular Medicine. Crump Institute for Molecular Imaging. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA.John Wayne Cancer Institute. Department of Translational Immunology. Santa Monica, CA, USA.University of California. Department of Molecular and Medical Pharmacology. California NanoSystems Institute. Johnson Comprehensive Cancer Center. Institute for Molecular Medicine. Crump Institute for Molecular Imaging. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. UCLA/Orthopedic Hospital Department of Orthopedic Surgery. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Department of Microbiology, Immunology and Molecular Genetics. Los Angeles, CA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Ri de Janeiro, RJ, Brasil.University of Southern California School of Medicine. Department of Dermathology. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. UCLA/Orthopedic Hospital Department of Orthopedic Surgery. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. UCLA/Orthopedic Hospital Department of Orthopedic Surgery. Los Angeles, CA, USA.Stanford University School of Medicine. Department of Microbiology and Immunology. Department of Medicine. Stanford, CA, USA .Stanford University School of Medicine. Department of Microbiology and Immunology. Department of Medicine. Stanford, CA, USA / 9Veterans Affairs Palo Alto Health Care System. Palo Alto, CA, USA.University Hospital of Ulm. Institute for Medical Microbiology and Hygiene. Germany.Harvard School of Public Health. Boston, MA, USA.University of California. David Geffen School of Medicine. Department of Microbiology, Immunology and Molecular Genetics. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA / University of California. David Geffen School of Medicine. Department of Microbiology, Immunology and Molecular Genetics. Los Angeles, CA, USA.Type I interferons (IFN-a and IFN-b) are important for protection against many viral infections, whereas type II interferon (IFN-g) is essential for host defense against some bacterial and parasitic pathogens. Study of IFN responses in human leprosy revealed an inverse correlation between IFN-b and IFN-g gene expression programs. IFN-g and its downstream vitamin D–dependent antimicrobial genes were preferentially expressed in self-healing tuberculoid lesions and mediated antimicrobial activity against the pathogen Mycobacterium leprae in vitro. In contrast, IFN-b and its downstream genes, including interleukin-10 (IL-10), were induced in monocytes by M. leprae in vitro and preferentially expressed in disseminated and progressive lepromatous lesions. The IFN-g–induced macrophage vitamin D–dependent antimicrobial peptide response was inhibited by IFN-b and by IL-10, suggesting that the differential production of IFNs contributes to protection versus pathogenesis in some human bacterial infections.Type I interferons (IFN-a and IFN-b)type II interferon (IFN-g)LeprosyAnti-MycobacterialMycobacterium lepraeMycobacterium lepraeHanseniaseInterferon Tipo IInterferon gamainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses |
| title |
Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses |
| spellingShingle |
Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses Teles, Rosane M. B. Type I interferons (IFN-a and IFN-b) type II interferon (IFN-g) Leprosy Anti-Mycobacterial Mycobacterium leprae Mycobacterium leprae Hanseniase Interferon Tipo I Interferon gama |
| title_short |
Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses |
| title_full |
Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses |
| title_fullStr |
Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses |
| title_full_unstemmed |
Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses |
| title_sort |
Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses |
| author |
Teles, Rosane M. B. |
| author_facet |
Teles, Rosane M. B. Graeber, Thomas G. Krutzik, Stephan R. Montoya, Dennis Schenk, Mirjam Lee, Delphine J. Komisopoulou, Evangelia Kelly-Scumpia, Kindra Chun, Rene Iyer, Shankar S. Sarno, Euzenir Nunes Rea, Thomas H. Hewison, Martin Adams, John S. Popper, Stephen J. Relman, David A. Stenger, Steffen Bloom, Barry R. Cheng, Genhong Modlin, Robert L. |
| author_role |
author |
| author2 |
Graeber, Thomas G. Krutzik, Stephan R. Montoya, Dennis Schenk, Mirjam Lee, Delphine J. Komisopoulou, Evangelia Kelly-Scumpia, Kindra Chun, Rene Iyer, Shankar S. Sarno, Euzenir Nunes Rea, Thomas H. Hewison, Martin Adams, John S. Popper, Stephen J. Relman, David A. Stenger, Steffen Bloom, Barry R. Cheng, Genhong Modlin, Robert L. |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Teles, Rosane M. B. Graeber, Thomas G. Krutzik, Stephan R. Montoya, Dennis Schenk, Mirjam Lee, Delphine J. Komisopoulou, Evangelia Kelly-Scumpia, Kindra Chun, Rene Iyer, Shankar S. Sarno, Euzenir Nunes Rea, Thomas H. Hewison, Martin Adams, John S. Popper, Stephen J. Relman, David A. Stenger, Steffen Bloom, Barry R. Cheng, Genhong Modlin, Robert L. |
| dc.subject.en.pt_BR.fl_str_mv |
Type I interferons (IFN-a and IFN-b) type II interferon (IFN-g) Leprosy Anti-Mycobacterial Mycobacterium leprae |
| topic |
Type I interferons (IFN-a and IFN-b) type II interferon (IFN-g) Leprosy Anti-Mycobacterial Mycobacterium leprae Mycobacterium leprae Hanseniase Interferon Tipo I Interferon gama |
| dc.subject.decs.pt_BR.fl_str_mv |
Mycobacterium leprae Hanseniase Interferon Tipo I Interferon gama |
| description |
University of California. David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, USA. |
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2013 |
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2013 |
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2016-01-21T14:06:52Z |
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2016-01-21T14:06:52Z |
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info:eu-repo/semantics/article |
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TELES, Rosane M. B. et al. Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses. Science, v.339, p.1448-1453, March 2013. |
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https://www.arca.fiocruz.br/handle/icict/12579 |
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1095-9203 |
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10.1126/science.1233665 |
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TELES, Rosane M. B. et al. Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses. Science, v.339, p.1448-1453, March 2013. 1095-9203 10.1126/science.1233665 |
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American Association for the Advancement of Science |
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American Association for the Advancement of Science |
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